Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex

Type 4 Phosphodiesterase Plays Different Integrating Roles in Different Cellular Domains in Pyramidal Cortical Neurons

(2010) L. R. V. Castro et al.   JOURNAL OF NEUROSCIENCE

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission

(2010) Akinori Nishi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice

(2009) Koichi Tanda et al.   Molecular Brain

The Role of Phosphodiesterases in Schizophrenia

(2008) Judith A Siuciak   CNS DRUGS

Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

(2008) A. Nishi et al.   JOURNAL OF NEUROSCIENCE

Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population

(2008) Shusuke Numata et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

(2008) Helen S Bateup et al.   NATURE NEUROSCIENCE

PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia

(2008) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH