A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human β-Cell Replication and Survival as well as GABA’s Ability to Inhibit Inflammatory T Cells

GABA dramatically improves glucose tolerance in streptozotocin-induced diabetic rats fed with high-fat diet

(2018) Shahla Sohrabipour et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GABA A receptor: Positive and negative allosteric modulators

(2018) Richard W. Olsen   NEUROPHARMACOLOGY

Wheat bran with enriched gamma-aminobutyric acid attenuates glucose intolerance and hyperinsulinemia induced by a high-fat diet

(2018) Wenting Shang et al.   Food & Function

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4 + T Cells and Is Immunosuppressive in Type 1 Diabetes

(2018) Amol K. Bhandage et al.   EBioMedicine

Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis

(2018) Jide Tian et al.   Scientific Reports

Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication

(2017) Jide Tian et al.   Scientific Reports

Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration

(2016) Kristie I. Aamodt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Current Concepts on the Pathogenesis of Type 1 Diabetes—Considerations for Attempts to Prevent and Reverse the Disease

(2015) Mark A. Atkinson et al.   DIABETES CARE

The anti-spasticity drug baclofen alleviates collagen-induced arthritis and regulates dendritic cells

(2015) Shichao Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction

(2014) Christopher D. Schmoutz et al.   BEHAVIOURAL BRAIN RESEARCH

Combined Therapy With GABA and Proinsulin/Alum Acts Synergistically to Restore Long-term Normoglycemia by Modulating T-Cell Autoimmunity and Promoting  -Cell Replication in Newly Diabetic NOD Mice

(2014) J. Tian et al.   DIABETES

GABA Promotes Human  -Cell Proliferation and Modulates Glucose Homeostasis

(2014) I. Purwana et al.   DIABETES

 -Aminobutyric Acid Regulates Both the Survival and Replication of Human  -Cells

(2013) J. Tian et al.   DIABETES

GABA Protects Human Islet Cells Against the Deleterious Effects of Immunosuppressive Drugs and Exerts Immunoinhibitory Effects Alone

(2013) Gérald J. Prud’homme et al.   TRANSPLANTATION

Recent Lessons Learned From Prevention and Recent-Onset Type 1 Diabetes Immunotherapy Trials

(2012) Teodora P. Staeva et al.   DIABETES

Different Subtypes of GABA-A Receptors Are Expressed in Human, Mouse and Rat T Lymphocytes

(2012) Suresh K. Mendu et al.   PLoS One

GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii

(2012) Jonas M. Fuks et al.   PLoS Pathogens

Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis

(2011) Jide Tian et al.   AUTOIMMUNITY

Oral Treatment with γ-Aminobutyric Acid Improves Glucose Tolerance and Insulin Sensitivity by Inhibiting Inflammation in High Fat Diet-Fed Mice

(2011) Jide Tian et al.   PLoS One

Combining Antigen-Based Therapy with GABA Treatment Synergistically Prolongs Survival of Transplanted ß-Cells in Diabetic NOD Mice

(2011) Jide Tian et al.   PLoS One

GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes

(2011) N. Soltani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effects of the GABAB receptor agonist baclofen in allergic contact dermatitis

(2010) Beatrice Duthey et al.   EXPERIMENTAL DERMATOLOGY

Increased GABAA channel subunits expression in CD8+ but not in CD4+ T cells in BB rats developing diabetes compared to their congenic littermates

(2010) Suresh Kumar Mendu et al.   MOLECULAR IMMUNOLOGY

Inhibitory role for GABA in autoimmune inflammation

(2010) R. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA