New insights into germ cell tumor genomics

Large-scale Sequencing of Testicular Germ Cell Tumour (TGCT) Cases Excludes Major TGCT Predisposition Gene

(2018) Kevin Litchfield et al.   EUROPEAN UROLOGY

Integrated Molecular Characterization of Testicular Germ Cell Tumors

(2018) Hui Shen et al.   Cell Reports

Testicular cancer

(2018) Liang Cheng et al.   Nature Reviews Disease Primers

Serum Levels of MicroRNA miR-371a-3p: A Sensitive and Specific New Biomarker for Germ Cell Tumours

(2017) Klaus-Peter Dieckmann et al.   EUROPEAN UROLOGY

Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor

(2017) Kevin Litchfield et al.   NATURE GENETICS

Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor

(2017) Zhaoming Wang et al.   NATURE GENETICS

Prognostic role of programmed-death ligand 1 (PD-L1) expressing tumor infiltrating lymphocytes in testicular germ cell tumors

(2017) Michal Chovanec et al.   Oncotarget

Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer

(2017) Timothy M. Pierpont et al.   Cell Reports

Activity of immune checkpoint inhibition in platinum refractory germ-cell tumors

(2016) S. Zschäbitz et al.   ANNALS OF ONCOLOGY

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pan-Cancer Immunogenomic Perspective on the Tumor Microenvironment Based on PD-L1 and CD8 T-Cell Infiltration

(2016) C.-Y. Ock et al.   CLINICAL CANCER RESEARCH

Variation in the HFE gene is associated with the development of bleomycin-induced pulmonary toxicity in testicular cancer patients

(2016) Gabriela G.F. van der Schoot et al.   EUROPEAN JOURNAL OF CANCER

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours

(2016) Holger Moch et al.   EUROPEAN UROLOGY

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors

(2016) Aditya Bagrodia et al.   JOURNAL OF CLINICAL ONCOLOGY

PD34-08 IMMUNE PROFILING OF TESTICULAR GERM CELL TUMORS REVEALS HIGH EXPRESSION OF PD-L1 AND PD-1

(2016) Diana Taheri et al.   JOURNAL OF UROLOGY

Genomic evolution and chemoresistance in germ-cell tumours

(2016) Amaro Taylor-Weiner et al.   NATURE

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Reversal effect of ouabain on multidrug resistance in esophageal carcinoma EC109/CDDP cells by inhibiting the translocation of Wnt/β-catenin into the nucleus

(2016) Yucheng Shen et al.   TUMOR BIOLOGY

Differences in global DNA methylation of testicular seminoma are not associated with changes in histone modifications, clinical prognosis, BRAF mutations or gene expression

(2016) Louise Holm Pedersen et al.   Cancer Genetics

Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer

(2016) Maryam Zanjirband et al.   Oncotarget

Prognostic value of programmed-death-1 receptor (PD-1) and its ligand 1 (PD-L1) in testicular germ cell tumors

(2015) Z. Cierna et al.   ANNALS OF ONCOLOGY

KRAS as a Therapeutic Target

(2015) F. McCormick   CLINICAL CANCER RESEARCH

Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas

(2015) Ioana Cutcutache et al.   EUROPEAN UROLOGY

Circulating Serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as Biomarkers in Patients with Testicular Germ Cell Cancer

(2015) Isabella Syring et al.   JOURNAL OF UROLOGY

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity

(2015) YEE-LIN VOON et al.   ONCOLOGY REPORTS

Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours

(2015) Kevin Litchfield et al.   Nature Communications

The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer

(2015) Christophe Deben et al.   Oncotarget

Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors

(2015) Martin A. Rijlaarsdam et al.   PLoS One

Development and Validation of a Gene-Based Model for Outcome Prediction in Germ Cell Tumors Using a Combined Genomic and Expression Profiling Approach

(2015) James E. Korkola et al.   PLoS One

Quantifying the heritability of testicular germ cell tumour using both population-based and genomic approaches

(2015) Kevin Litchfield et al.   Scientific Reports

Presence of Somatic Mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in Cisplatin-Resistant Germ Cell Tumors

(2014) D. R. Feldman et al.   CLINICAL CANCER RESEARCH

Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9

(2013) Jacqueline L.Y. Chee et al.   CELL CYCLE

Molecular biology of testicular germ cell tumors: Unique features awaiting clinical application

(2013) Ludmila Boublikova et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Acquisition of epithelial–mesenchymal transition phenotype and cancer stem cell-like properties in cisplatin-resistant lung cancer cells through AKT/β-catenin/Snail signaling pathway

(2013) Hao Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phenotypic characterisation of immune cell infiltrates in testicular germ cell neoplasia

(2013) Tine Hvarness et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation

(2013) Luc G T Morris et al.   NATURE GENETICS

Methylation of an intronic region regulates miR-199a in testicular tumor malignancy

(2011) H-H Cheung et al.   ONCOGENE

Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway

(2011) R Koster et al.   Cell Death & Disease

Regulation of Excision Repair Cross-Complementation Group 1 by Snail Contributes to Cisplatin Resistance in Head and Neck Cancer

(2010) D. S.-S. Hsu et al.   CLINICAL CANCER RESEARCH

No evidence for V600E BRAF mutation in the seminoma cell line TCam-2

(2010) N. C. Goddard et al.   GENES CHROMOSOMES & CANCER

Analysis of the adenomatous polyposis coli (APC) gene in childhood and adolescent germ cell tumors

(2010) Vera Okpanyi et al.   PEDIATRIC BLOOD & CANCER

E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

(2009) M Lizé et al.   CELL DEATH AND DIFFERENTIATION

Therapeutic Potential of Mdm2 Inhibition in Malignant Germ Cell Tumours

(2009) Sebastian Bauer et al.   EUROPEAN UROLOGY

Identification and Validation of a Gene Expression Signature That Predicts Outcome in Adult Men With Germ Cell Tumors

(2009) James E. Korkola et al.   JOURNAL OF CLINICAL ONCOLOGY

Microsatellite Instability, Mismatch Repair Deficiency, andBRAFMutation in Treatment-Resistant Germ Cell Tumors

(2009) Friedemann Honecker et al.   JOURNAL OF CLINICAL ONCOLOGY

Interaction of Programmed Death-1 and Programmed Death-1 Ligand-1 Contributes to Testicular Immune Privilege

(2009) Xuyang Cheng et al.   TRANSPLANTATION

The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

(2009) Phuong L. Mai et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Identification of genomic changes associated with cisplatin resistance in testicular germ cell tumor cell lines

(2008) Elodie E. Noel et al.   GENES CHROMOSOMES & CANCER