Tissue-specific mechanisms of alternative polyadenylation: Testis, brain, and beyond (2018 update)

Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease

(2018) Kevin Sun et al.   JOURNAL OF IMMUNOLOGY

PAPOLB/TPAP regulates spermiogenesis independently of chromatoid body-associated factors

(2018) Shin-ichi KASHIWABARA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation

(2018) Yong Zhu et al.   MOLECULAR CELL

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

(2018) Marcello Clerici et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Locally translated mTOR controls axonal local translation in nerve injury

(2018) Marco Terenzio et al.   SCIENCE

Widespread intronic polyadenylation diversifies immune cell transcriptomes

(2018) Irtisha Singh et al.   Nature Communications

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

(2018) Marcello Clerici et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cstf2t Regulates expression of histones and histone-like proteins in male germ cells

(2018) P. N. Grozdanov et al.   Andrology

A compendium of conserved cleavage and polyadenylation events in mammalian genes

(2018) Ruijia Wang et al.   GENOME RESEARCH

Genome-wide atlas of alternative polyadenylation in the forage legume red clover

(2018) Manohar Chakrabarti et al.   Scientific Reports

Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy

(2017) James D. Thomas et al.   GENES & DEVELOPMENT

cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation

(2017) Hun-Way Hwang et al.   NEURON

Alternative start and termination sites of transcription drive most transcript isoform differences across human tissues

(2017) Alejandro Reyes et al.   NUCLEIC ACIDS RESEARCH

Molecular basis for the recognition of the human AAUAAA polyadenylation signal

(2017) Yadong Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

(2017) Xiaochuan Liu et al.   RNA

Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation

(2017) Mariana M. Fontes et al.   Scientific Reports

Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

(2017) Marcello Clerici et al.   eLife

TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis1

(2016) Petar N. Grozdanov et al.   BIOLOGY OF REPRODUCTION

Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control

(2016) Wencheng Li et al.   BMC BIOLOGY

The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay

(2016) Eleen Y. Shum et al.   CELL

Genome-wide dynamics of alternative polyadenylation in rice

(2016) Haihui Fu et al.   GENOME RESEARCH

Distal Alternative Last Exons Localize mRNAs to Neural Projections

(2016) J. Matthew Taliaferro et al.   MOLECULAR CELL

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Processing and transcriptome expansion at the mRNA 3′ end in health and disease: finding the right end

(2016) Anton Ogorodnikov et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice

(2016) Jaryse C. Harris et al.   PLoS One

PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage

(2016) Hun-Way Hwang et al.   Cell Reports

Chromatoid Body Protein TDRD6 Supports Long 3’ UTR Triggered Nonsense Mediated mRNA Decay

(2016) Grigorios Fanourgakis et al.   PLoS Genetics

UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts

(2016) Jianqiang Bao et al.   PLoS Genetics

Neurodegeneration and RNA-binding proteins

(2016) Laura De Conti et al.   Wiley Interdisciplinary Reviews-RNA

RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development

(2015) Leah L. Zagore et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

(2015) Wencheng Li et al.   PLoS Genetics

NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylation

(2015) Vincenzo A Gennarino et al.   eLife

Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal

(2014) B. Lackford et al.   EMBO JOURNAL

CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3′ processing

(2014) Serena L. Chan et al.   GENES & DEVELOPMENT

Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33

(2014) Lars Schönemann et al.   GENES & DEVELOPMENT

Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease

(2014) Ranjan Batra et al.   MOLECULAR CELL

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

(2014) Chioniso P. Masamha et al.   NATURE

CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3′ end processing

(2014) Bradford A. Youngblood et al.   NUCLEIC ACIDS RESEARCH

CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defects

(2014) Bradford A. Youngblood et al.   Stem Cell Research

Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience

(2014) Joshua A. Ainsley et al.   Nature Communications

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

(2014) Zheng Xia et al.   Nature Communications

Implications of polyadenylation in health and disease

(2014) Ana Curinha et al.   Nucleus

Polyadenylation site-specific differences in the activity of the neuronal βCstF-64 protein in PC-12 cells

(2013) Ganesh S. Shankarling et al.   GENE

Widespread and extensive lengthening of 3' UTRs in the mammalian brain

(2013) P. Miura et al.   GENOME RESEARCH

The splicing landscape is globally reprogrammed during male meiosis

(2013) Ralf Schmid et al.   NUCLEIC ACIDS RESEARCH

Overlapping and distinct functions of CstF64 and CstF64  in mammalian mRNA 3' processing

(2013) C. Yao et al.   RNA

The Conserved Intronic Cleavage and Polyadenylation Site of CstF-77 Gene Imparts Control of 3′ End Processing Activity through Feedback Autoregulation and by U1 snRNP

(2013) Wenting Luo et al.   PLoS Genetics

Specificity factors in cytoplasmic polyadenylation

(2013) Amanda Charlesworth et al.   Wiley Interdisciplinary Reviews-RNA

Knockdown of pre-mRNA cleavage factor Im 25kDa promotes neurite outgrowth

(2012) Hidefumi Fukumitsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A quantitative atlas of polyadenylation in five mammals

(2012) Adnan Derti et al.   GENOME RESEARCH

An in-depth map of polyadenylation sites in cancer

(2012) Yuefeng Lin et al.   NUCLEIC ACIDS RESEARCH

The τCstF-64 Polyadenylation Protein Controls Genome Expression in Testis

(2012) Wencheng Li et al.   PLoS One

Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation

(2012) C. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6

(2012) I. Evsyukova et al.   RNA

Alternative polyadenylation: New insights from global analyses

(2012) Y. Shi   RNA

Genome-wide Analysis of Pre-mRNA 3′ End Processing Reveals a Decisive Role of Human Cleavage Factor I in the Regulation of 3′ UTR Length

(2012) Georges Martin et al.   Cell Reports

Genetics and Regulatory Impact of Alternative Polyadenylation in Human B-Lymphoblastoid Cells

(2012) Oh Kyu Yoon et al.   PLoS Genetics

Transcriptional Activators Enhance Polyadenylation of mRNA Precursors

(2011) Takashi Nagaike et al.   MOLECULAR CELL

Mechanisms and Consequences of Alternative Polyadenylation

(2011) Dafne Campigli Di Giammartino et al.   MOLECULAR CELL

Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation

(2011) Kyle D. Mansfield et al.   NUCLEIC ACIDS RESEARCH

Signals for pre-mRNA cleavage and polyadenylation

(2011) Bin Tian et al.   Wiley Interdisciplinary Reviews-RNA

The Spen Family Protein FPA Controls Alternative Cleavage and Polyadenylation of RNA

(2010) Csaba Hornyik et al.   DEVELOPMENTAL CELL

Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression

(2010) Carol S. Lutz et al.   Wiley Interdisciplinary Reviews-RNA

Tissue-specific mechanisms of alternative polyadenylation: testis, brain, and beyond

(2010) Clinton C. MacDonald et al.   Wiley Interdisciplinary Reviews-RNA

A family of splice variants of CstF-64 expressed in vertebrate nervous systems

(2009) Ganesh S Shankarling et al.   BMC MOLECULAR BIOLOGY

Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing

(2009) Kathleen Martincic et al.   NATURE IMMUNOLOGY

Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development

(2009) Z. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted 3' Processing of Antisense Transcripts Triggers Arabidopsis FLC Chromatin Silencing

(2009) F. Liu et al.   SCIENCE

Role of plant RNA-binding proteins in development, stress response and genome organization

(2009) Zdravko J. Lorković   TRENDS IN PLANT SCIENCE

Arabidopsis mRNA polyadenylation machinery: comprehensive analysis of protein-protein interactions and gene expression profiling

(2008) Arthur G Hunt et al.   BMC GENOMICS

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

(2008) Donny D. Licatalosi et al.   NATURE

Arabidopsis PCFS4, a homologue of yeast polyadenylation factor Pcf11p, regulates FCA alternative processing and promotes flowering time

(2008) Denghui Xing et al.   PLANT JOURNAL

Arabidopsis CLP1-SIMILAR PROTEIN3, an Ortholog of Human Polyadenylation Factor CLP1, Functions in Gametophyte, Embryo, and Postembryonic Development

(2008) D. Xing et al.   PLANT PHYSIOLOGY

Pre-Messenger RNA Cleavage Factor I (CFIm): Potential Role in Alternative Polyadenylation During Spermatogenesis1

(2007) Becky L. Sartini et al.   BIOLOGY OF REPRODUCTION