PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

The physiological regulation of macropinocytosis during Dictyostelium growth and development

(2018) Thomas D. Williams et al.   JOURNAL OF CELL SCIENCE

Genome sequencing and functional characterization of the non-pathogenic Klebsiella pneumoniae KpGe bacteria

(2018) Wanessa C. Lima et al.   MICROBES AND INFECTION

The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase

(2017) Roya M. Dayam et al.   JOURNAL OF IMMUNOLOGY

Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein

(2017) Jianhua Zhao et al.   PLoS Pathogens

PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment

(2016) Shefali Krishna et al.   DEVELOPMENTAL CELL

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors

(2016) Catherine M. Buckley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A plasma membrane template for macropinocytic cups

(2016) Douwe M Veltman et al.   eLife

The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use withDictyostelium discoideum

(2016) Andrew J. Davidson et al.   BIOTECHNIQUES

Phosphoinositides in phagocytosis and macropinocytosis

(2015) Roni Levin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Formation of a pathogen vacuole according toLegionella pneumophila: how to kill one bird with many stones

(2015) Ivo Finsel et al.   CELLULAR MICROBIOLOGY

The Fab1/PIKfyve Phosphoinositide Phosphate Kinase Is Not Necessary to Maintain the pH of Lysosomes and of the Yeast Vacuole

(2015) Cheuk Y. Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccinia Virus Infection Requires Maturation of Macropinosomes

(2015) Zaira Rizopoulos et al.   TRAFFIC

The Phosphoinositide-Gated Lysosomal Ca2+Channel, TRPML1, Is Required for Phagosome Maturation

(2015) Roya M. Dayam et al.   TRAFFIC

The fungal pathogenCryptococcus neoformansmanipulates macrophage phagosome maturation

(2014) Leanne M. Smith et al.   CELLULAR MICROBIOLOGY

Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling

(2014) J. Clark et al.   EMBO JOURNAL

The Legionella longbeachae Icm/Dot Substrate SidC Selectively Binds Phosphatidylinositol 4-Phosphate with Nanomolar Affinity and Promotes Pathogen Vacuole-Endoplasmic Reticulum Interactions

(2014) Stephanie Dolinsky et al.   INFECTION AND IMMUNITY

PIP3-dependent macropinocytosis is incompatible with chemotaxis

(2014) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

The signaling lipid PI(3,5)P2 stabilizes V1–Vo sector interactions and activates the V-ATPase

(2014) Sheena Claire Li et al.   MOLECULAR BIOLOGY OF THE CELL

PIKfyve Inhibition Interferes with Phagosome and Endosome Maturation in Macrophages

(2014) Grace H.E. Kim et al.   TRAFFIC

Vmp1 Regulates PtdIns3P Signaling During Autophagosome Formation inDictyostelium discoideum

(2014) Javier Calvo-Garrido et al.   TRAFFIC

Live-Cell Imaging of Phosphoinositide Dynamics and Membrane Architecture during Legionella Infection

(2014) S. Weber et al.   mBio

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

(2014) Sang H. Min et al.   Nature Communications

Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance

(2013) Amber J. McCartney et al.   BIOESSAYS

The Legionella Effector RidL Inhibits Retrograde Trafficking to Promote Intracellular Replication

(2013) Ivo Finsel et al.   Cell Host & Microbe

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

(2013) Xinming Cai et al.   CHEMISTRY & BIOLOGY

Cyclical Action of the WASH Complex: FAM21 and Capping Protein Drive WASH Recycling, Not Initial Recruitment

(2013) Laura Park et al.   DEVELOPMENTAL CELL

Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease

(2013) Robert H. Michell   FEBS Journal

LtpD Is a Novel Legionella pneumophila Effector That Binds Phosphatidylinositol 3-Phosphate and Inositol Monophosphatase IMPA1

(2013) Clare R. Harding et al.   INFECTION AND IMMUNITY

Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions

(2013) S. Takasuga et al.   JOURNAL OF BIOCHEMISTRY

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

Rapid Structural Changes and Acidification of Guard Cell Vacuoles during Stomatal Closure Require Phosphatidylinositol 3,5-Bisphosphate

(2013) G. Bak et al.   PLANT CELL

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

(2013) Sally Martin et al.   PLoS One

Domain organization of Legionella effector SetA

(2012) Thomas Jank et al.   CELLULAR MICROBIOLOGY

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P2and PI(5)P

(2012) Yanling Zhang et al.   EMBO JOURNAL

Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics

(2012) Kaoru Hazeki et al.   FEBS LETTERS

Mucolipin controls lysosome exocytosis in Dictyostelium

(2012) W. C. Lima et al.   JOURNAL OF CELL SCIENCE

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P

(2012) S. N. Zolov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulation of host vesicular trafficking and innate immune defence by Legionella Dot/Icm effectors

(2011) Jianning Ge et al.   CELLULAR MICROBIOLOGY

Dictyostelium discoideum as a Model System for Identification of Burkholderia pseudomallei Virulence Factors

(2011) Benjamin M. Hasselbring et al.   INFECTION AND IMMUNITY

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis

(2011) Michael Carnell et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylinositol-3,5-Bisphosphate: No Longer the Poor PIP2

(2011) Cheuk Y. Ho et al.   TRAFFIC

Dynamin A, Myosin IB and Abp1 Couple Phagosome Maturation to F-Actin Binding

(2011) Navin Gopaldass et al.   TRAFFIC

Legionellaspp. outdoors: colonization, communication and persistence

(2011) Hubert Hilbi et al.   Environmental Microbiology Reports

Anchors for Effectors: Subversion of Phosphoinositide Lipids by Legionella

(2011) Hubert Hilbi et al.   Frontiers in Microbiology

Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors

(2010) Andree Hubber et al.   Annual Review of Cell and Developmental Biology

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

(2010) Markus C Kerr et al.   EMBO JOURNAL

Effect of Starvation on the Endocytic Pathway in Dictyostelium Cells

(2010) Ewan W. Smith et al.   EUKARYOTIC CELL

A Myosin IK-Abp1-PakB Circuit Acts as a Switch to Regulate Phagocytosis Efficiency

(2010) Régis Dieckmann et al.   MOLECULAR BIOLOGY OF THE CELL

Retrieval of the Vacuolar H+-ATPase from Phagosomes Revealed by Live Cell Imaging

(2010) Margaret Clarke et al.   PLoS One

Genetic Control of Lithium Sensitivity and Regulation of Inositol Biosynthetic Genes

(2010) Jason King et al.   PLoS One

Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila Effector

(2010) Li Xu et al.   PLoS Pathogens

YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

(2009) Ognian C. Ikonomov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells

(2009) J. S. King et al.   Disease Models & Mechanisms

PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death

(2009) Fuminori Tsuruta et al.   JOURNAL OF CELL BIOLOGY

Dictyostelium discoideum: a model host to measure bacterial virulence

(2009) Romain Froquet et al.   Nature Protocols

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

PIKfyve Regulation of Endosome-Linked Pathways

(2009) Jane de Lartigue et al.   TRAFFIC

Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration

(2008) Xuebao Zhang et al.   BRAIN

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

(2008) Harold B J Jefferies et al.   EMBO REPORTS

Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein ofLegionella pneumophila

(2008) Eva Brombacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

(2008) Ralph R. Isberg et al.   NATURE REVIEWS MICROBIOLOGY

A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum

(2008) Douwe M. Veltman et al.   PLASMID

Icm/Dot-dependent upregulation of phagocytosis by Legionella pneumophila

(2003) Hubert Hilbi et al.   MOLECULAR MICROBIOLOGY