期刊
FEBS LETTERS
卷 586, 期 22, 页码 4010-4015出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.09.043
关键词
IgG-opsonized red blood cell; Phagosome maturation; Phosphoinositide 3 '-phosphatase; PTEN; PIKfyve; RAW264.7 macrophage
资金
- Japan Society for the Promotion of Science [23590078, 22590065]
- Grants-in-Aid for Scientific Research [23590078, 24659124, 22590065] Funding Source: KAKEN
PtdIns(3) P (phosphatidylinositol 3-phosphate) is a signaling molecule important for phagosome maturation. The major role of Vps34 in production of phagosomal PtdIns(3) P has been indicated. However, the fate of the newly generated PtdIns(3) P has not been well described. Here we show that elimination of PtdIns(3) P from phagosomal membrane was significantly delayed in RAW264.7 macrophages lacking PTEN or PIKfyve. In the PTEN-deficient cells treated with a PIKfyve inhibitor, degradation of PtdIns(3) P was almost lost, indicating that PTEN and PIKfyve are two major players in phagosomal PtdIns(3) P metabolism. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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