Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity

Myoglobin-Catalyzed Olefination of Aldehydes

(2016) Vikas Tyagi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of chiral 2-alkanols fromn-alkanes by aP. putidawhole-cell biocatalyst

(2016) Florian Tieves et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation

(2016) Joshua G. Gober et al.   CHEMBIOCHEM

Designing ‘Totem’C2-Symmetrical Iron Porphyrin Catalysts for Stereoselective Cyclopropanations

(2016) Daniela Maria Carminati et al.   CHEMISTRY-A EUROPEAN JOURNAL

The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

(2016) Tanaji T. Talele   JOURNAL OF MEDICINAL CHEMISTRY

Abiological catalysis by artificial haem proteins containing noble metals in place of iron

(2016) Hanna M. Key et al.   NATURE

Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor

(2016) Katharina G. Hugentobler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient conversion of primary azides to aldehydes catalyzed by active site variants of myoglobin

(2016) Simone Giovani et al.   Chemical Science

Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases

(2016) Jan-Ytzen van der Meer et al.   Nature Communications

Guidelines for development and implementation of biocatalytic P450 processes

(2015) Marie T. Lundemo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

(2015) Gopeekrishnan Sreenilayam et al.   CHEMICAL COMMUNICATIONS

Intermolecular carbene S–H insertion catalysed by engineered myoglobin-based catalysts

(2015) Vikas Tyagi et al.   Chemical Science

Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation

(2015) Poonam Srivastava et al.   Nature Communications

Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran

(2014) Z. Jane Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Diastereoselective and Enantioselective Olefin Cyclopropanation Using Engineered Myoglobin-Based Catalysts

(2014) Melanie Bordeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intramolecular C(sp3)H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts

(2014) Melanie Bordeaux et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases

(2014) Philipp N. Scheller et al.   CHEMBIOCHEM

Whole-cell double oxidation of n-heptane

(2014) Christina A. Müller et al.   JOURNAL OF BIOTECHNOLOGY

Residues Controlling Facial Selectivity in an Alkene Reductase and Semirational Alterations to Create Stereocomplementary Variants

(2014) Adam Z. Walton et al.   ACS Catalysis

P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions

(2014) Hans Renata et al.   Catalysis Science & Technology

Laboratory Evolution of Enantiocomplementary Candida antarctica Lipase B Mutants with Broad Substrate Scope

(2013) Qi Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

(2013) Pedro S Coelho et al.   Nature Chemical Biology

Application of a new versatile electron transfer system for cytochrome P450-based Escherichia coli whole-cell bioconversions

(2012) Michael Ringle et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents

(2012) Hao Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

(2012) P. S. Coelho et al.   SCIENCE

Convergent Asymmetric Synthesis of Two Complex TRPV1 Antagonists

(2011) Kenneth J. Butcher et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli

(2010) Rudi Fasan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Enantiocomplementary Enzymes: Classification, Molecular Basis for Their Enantiopreference, and Prospects for Mirror-Image Biotransformations

(2008) Paul F. Mugford et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Cyclopropanation of Olefins Catalyzed by Chiral Cobalt(II)-Binaphthyl Porphyrins

(2008) Simone Fantauzzi et al.   ORGANOMETALLICS

Recent developments in asymmetric cyclopropanation

(2008) Hélène Pellissier   TETRAHEDRON