Review
Polymer Science
Izzat Zulkiflee, Syafira Masri, Mazlan Zawani, Atiqah Salleh, Ibrahim Nor Amirrah, Mohd Farhanulhakim Mohd Razip Wee, Salma Mohamad Yusop, Mh Busra Fauzi
Summary: Silicon-based biomaterials have gained significant breakthroughs in various industries, including clinical and biomedical applications. Their highly favorable properties, such as excellent biocompatibility, high surface area, mechanical strength, and selectivity, make them attractive for applications like film, hydrogel, nanoparticles, etc. Exciting results have also been observed in cell culture, cell growth, and tissue engineering. This article provides a simple review of the unique properties of silicon and discusses its future application perspectives in the biomedical field, with the goal of generating broader interest in silicone-based materials for wound healing research.
Article
Emergency Medicine
Pratik Das, Suvendu Manna, Shivam Roy, Samit K. Nandi, Piyali Basak
Summary: This review examines the use of biomaterials for wound healing, focusing on natural and synthetic polymer composites and their mechanisms of action. It highlights the advancements in the field and the challenges posed by the availability and suitability of biomaterials for clinical use.
Review
Biochemistry & Molecular Biology
Daniel Diaz-Garcia, Alzbeta Filipova, Idalia Garza-Veloz, Margarita L. Martinez-Fierro
Summary: The skin serves as a physical barrier against environmental threats and pathogens, with its regeneration relying on various skin stem cell compartments. While skin wounds typically heal without issue, certain conditions or severe damage can impede the healing process. Non-healing wounds present a serious and potentially life-threatening situation that may necessitate advanced therapeutic interventions, with a focus on stem cells playing a significant role in potential treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Biotechnology & Applied Microbiology
Nur Izzah Md Fadilah, Shaima Maliha Riha, Zawani Mazlan, Adzim Poh Yuen Wen, Looi Qi Hao, Blessy Joseph, Manira Maarof, Sabu Thomas, Antonella Motta, Mh Busra Fauzi
Summary: Skin tissue engineering holds great potential for successful wound and tissue loss treatments that current methods cannot achieve. The use of multifunctional bioscaffolds, made from natural and synthetic biomaterials, offers an environment that enhances biological performance and accelerates skin tissue regeneration. These bioscaffolds provide a biomimetic framework that guides cell regeneration and can be customized to distribute bioactive chemicals or cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Polymer Science
Yt Jun Cheah, Muhamad Ramdzan Buyong, Mohd Heikal Mohd Yunus
Summary: Electrical stimulation is a promising field in wound healing, offering various mechanisms and approaches to enhance wound repair. Understanding the effects of electrical stimulation on cellular and molecular levels can improve the speed and quality of wound healing. Exploring the application and integration of electroconductive biomaterials has opened up new possibilities for modern wound dressings.
Review
Biotechnology & Applied Microbiology
Jinli Zhang, Changling Liu, Xiaojian Li, Zhihe Liu, Zhi Zhang
Summary: Hydrogels play a significant role in wound nursing by promoting wound healing and tissue remodeling through reducing inflammation, facilitating vascularization, and supporting cell growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Polymer Science
Shaima Maliha Riha, Manira Maarof, Mh Busra Fauzi
Summary: Skin tissue engineering has made significant progress in wound healing treatment by incorporating stem cells into biomaterials to enhance their delivery and therapeutic effects. The use of biomaterials as a platform improves the engraftment of implanted cells and facilitates the function of exogenous cells by mimicking the tissue microenvironment.
Article
Biochemistry & Molecular Biology
Mairobi Persinal-Medina, Sara Llames, Manuel Chacon, Natalia Vazquez, Marta Pevida, Ignacio Alcalde, Sergio Alonso-Alonso, Laura Maria Martinez-Lopez, Jesus Merayo-Lloves, Alvaro Meana
Summary: This study developed a polymerizable skin hydrogel consisting of keratinocytes and fibroblast within a fibrin scaffold. The results showed that this hydrogel can effectively regenerate skin wounds, shortening the time needed for transplantation compared to other skin models. It is suggested that this polymerizable skin hydrogel is an inexpensive, easy and rapid treatment for improving the treatment of skin wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Hamed Nosrati, Reza Aramideh Khouy, Ali Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Korosh Ashrafi-Dehkordi, Samira Sanami, Zohreh Alizadeh
Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Materials Science, Multidisciplinary
Zijian Wang, Weikang Hu, Wang Wang, Yu Xiao, Yun Chen, Xinghuan Wang
Summary: This review summarizes the impact of bacterial infection on wound healing and presents the latest advances in antibacterial nanofibrous materials for accelerating the healing process. By incorporating substances such as antibiotics, antimicrobial peptides, metals, and antibacterial polymers into ENMs, the antibacterial activity of ENMs is enhanced.
ADVANCED FIBER MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Yan Li, Juan Wang, Yan Wang, Wenguo Cui
Summary: Hydrogel fibers, derived from the combination of hydrogel and electrospinning, have shown great potential in tissue regeneration and wound healing due to their structural properties and biological functions. Researchers have been particularly interested in the high specific surface area and mechanical advantages provided by these materials, making them promising for various biomedical applications.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Engineering, Biomedical
Siming Zhang, Gaoran Ge, Yi Qin, Wenhao Li, Jiale Dong, Jiawei Mei, Ruixiang Ma, Xianzuo Zhang, Jiaxiang Bai, Chen Zhu, Weiwei Zhang, Dechun Geng
Summary: Poor wound healing after diabetes mellitus is characterized by persistent bleeding, inflammation dysregulation, blocked cell proliferation, infection susceptibility, and impaired tissue remodeling. Conventional wound dressings have limited functionality and fail to meet the requirements of diabetic wound healing. Stimuli-responsive hydrogels, which can change their properties in response to various stimuli, have shown promise in improving therapeutic efficacy and reducing toxicity for diabetic wound healing.
MATERIALS TODAY BIO
(2023)
Review
Emergency Medicine
Zonghao Hu, Zishun Qin, Yue Qu, Feng Wang, Benheng Huang, Gaigai Chen, Xiaoyuan Liu, Lihua Yin
Summary: This article summarizes the potential of cell electrospinning (C-ES) technology, based on the technique of electrospinning (ES), in promoting wound healing. It discusses the advantages of C-ES, the differences between C-ES and traditional ES, suitable parameters for maintaining cytoactivity, material selection and design, and the application of C-ES in biomaterials and cells. It also explores the limitations and improved methods of C-ES.
Review
Pharmacology & Pharmacy
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
Summary: Chronic wounds in poorly managed diabetics are difficult to heal due to long-term uncontrolled blood glucose levels. To prevent complications, special medical care is needed. Nanofibrous scaffolds are a promising treatment due to their flexibility, ability to load bioactive compounds, and biomimetic environment for cell proliferation.
Article
Engineering, Biomedical
Bhushan P. Mahadik, Sara Pedron Haba, Luke J. Skertich, Brendan A. C. Harley
Review
Biochemical Research Methods
Ji Sun Choi, Bhushan P. Mahadik, Brendan A. C. Harley
BIOTECHNOLOGY JOURNAL
(2015)
Review
Biochemical Research Methods
Ji Sun Choi, Bhushan P. Mahadik, Brendan A. C. Harley
BIOTECHNOLOGY JOURNAL
(2015)
Article
Materials Science, Multidisciplinary
S. Pedron, H. Polishetty, A. M. Pritchard, B. P. Mahadik, J. N. Sarkaria, B. A. C. Harley
MRS COMMUNICATIONS
(2017)
Article
Engineering, Biomedical
Bhushan P. Mahadik, Tobias D. Wheeler, Luke J. Skertich, Paul J. A. Kenis, Brendan A. C. Harley
ADVANCED HEALTHCARE MATERIALS
(2014)
Article
Multidisciplinary Sciences
Bhushan Mahadik, Bruce Hannon, Brendan A. C. Harley
Article
Chemistry, Multidisciplinary
Sarah Van Belleghem, Leopoldo Torres, Marco Santoro, Bhushan Mahadik, Arley Wolfand, Peter Kofinas, John P. Fisher
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Engineering, Biomedical
Justine R. Yu, Miriam Janssen, Barry J. Liang, Huang-Chiao Huang, John P. Fisher
ACTA BIOMATERIALIA
(2020)
Article
Engineering, Biomedical
Guang Yang, Bhushan Mahadik, Ji Young Choi, Justine R. Yu, Trevor Mollot, Bin Jiang, Xiaoming He, John P. Fisher
Summary: The study utilized a microfluidic approach to prepare collagen microbeads loaded with human bone marrow derived mesenchymal stem cells for creating engineered bone grafts. The cell-laden microbeads self-assembled into macro-tissues, enabling precise control over cell spatial distribution at the macroscale, offering flexibility for graft volume and architecture. The approach has the potential to create 3D engineered bone grafts with customized vasculature using modular tissue engineering and 3D printing.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Sarah Van Belleghem, Bhushan Mahadik, Kirstie Snodderly, Zoe Mote, Bin Jiang, Justine R. Yu, Shannon McLoughlin, Xiaoming He, Arthur J. Nam, John P. Fisher
Summary: Breast cancer and mastectomy have significant physical and emotional impacts on women, and restoring the nipple-areola complex is crucial for psychological healing. This study introduces 3D printed hybrid scaffolds as a potential long-term solution for nipple reconstruction challenges.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Materials Science, Biomaterials
Justine R. Yu, Pranav Varrey, Barry J. Liang, Huang-Chiao Huang, John P. Fisher
Summary: This study demonstrates the use of a hydrogel-based biomaterial releasing SDF-1 alpha to recruit and polarize macrophages, promoting skin regeneration and wound closure in chronic wounds.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Engineering, Biomedical
Jesse K. Placone, Bhushan Mahadik, John P. Fisher
APL BIOENGINEERING
(2020)
Article
Engineering, Biomedical
Shushan P. Mahadik, Narayanan A. K. Bharadwaj, Randy H. Ewoldt, Brendan A. C. Harley