Rational Design of Proteasome Inhibitors as Antimalarial Drugs

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

(2016) Hao Li et al.   NATURE

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

(2015) Paula C.A. da Fonseca et al.   Nature Communications

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes

(2014) Hao Li et al.   ACS Chemical Biology

Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the α-Ketoamide Electrophile as an Auspicious Reversible Lead Motif

(2014) Martin L. Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Potent and Selective Non-covalent Inhibitors of the Plasmodium falciparum Proteasome

(2014) Hao Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets

(2013) Gang Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibitors for the Immuno- and Constitutive Proteasome: Current and Future Trends in Drug Development

(2012) Eva Maria Huber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Validation of the Proteasome as a Therapeutic Target in Plasmodium Using an Epoxyketone Inhibitor with Parasite-Specific Toxicity

(2012) Hao Li et al.   CHEMISTRY & BIOLOGY