期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 27, 页码 9968-9971出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja400021x
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资金
- NIH [R56AI080618, 1R21AI101393]
- Milstein Program in Chemical Biology of Infectious Diseases
- William Randolph Hearst Foundation
We identified N,C-capped dipeptides that are selective for the Mycobacterium tuberculosis proteasome over human constitutive and immunoproteasomes. Differences in the S3 and Si binding pockets appeared to account for the species selectivity. The inhibitors can penetrate mycobacteria and kill nonreplicating M. tuberculosis under nitrosative stress.
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