Article
Cell Biology
Mariano F. Zacarias-Fluck, Daniel Masso-Valles, Fabio Giuntini, Inigo Gonzalez-Larreategui, Jastrinjan Kaur, Silvia Casacuberta-Serra, Toni Jauset, Sandra Martinez-Martin, Genesis Martin-Fernandez, Erika Serrano del Pozo, Laia Foradada, Judit Grueso, Lara Nonell, Marie-Eve Beaulieu, Jonathan R. Whitfield, Laura Soucek
Summary: In melanoma, inhibiting MYC with Omomyc leads to decreased tumor growth and metastatic capacity, and improves patient prognosis, highlighting the therapeutic potential of MYC inhibition in this disease.
GENES & DEVELOPMENT
(2023)
Article
Multidisciplinary Sciences
Guangan Hu, Yang Su, Byong Ha Kang, Zhongqi Fan, Ting Dong, Douglas R. Brown, Jaime Cheah, Karl Dane Wittrup, Jianzhu Chen
Summary: Macrophages exhibit plasticity and can polarize into various phenotypes in response to different stimuli. Through high-throughput screening of a library of around 4000 compounds, researchers identified compounds that can activate human macrophages towards specific polarization states, with some capable of reprogramming macrophages between different states. Transcriptional analysis helped uncover the pathways and targets through which these compounds modulate macrophage activation.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando J. Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M. Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W. Pouton, Anthony W. Purcell, Owen J. L. Rackham, Enrico Petretto, Jose M. Polo
Summary: The study reveals that microglia associated with A beta plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer's disease (AD) models. This suggests that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mouse model of AD.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Timothy Wu, Jennifer M. Deger, Hui Ye, Caiwei Guo, Justin Dhindsa, Brandon T. Pekarek, Rami Al-Ouran, Zhandong Liu, Ismael Al-Ramahi, Juan Botas, Joshua M. Shulman
Summary: Aging is a major risk factor for Alzheimer's disease, and cell-type vulnerability plays a crucial role in its clinical manifestations. The study found that tau protein-induced changes in gene expression are mainly concentrated in excitatory neurons and glia cells and can activate or suppress innate immune gene expression in a cell-type-specific manner. Furthermore, the research also highlights the conservation of cell-type-specific transcriptional patterns between fruit flies and human brain tissue.
Article
Microbiology
Mohamed Belal Hamed, Ewa Burchacka, Liselotte Angus, Arnaud Marchand, Jozefien De Geyter, Maria S. Loos, Jozef Anne, Hugo Klaassen, Patrick Chaltin, Spyridoula Karamanou, Anastassios Economou
Summary: The study identified 14 secretion inhibitors with potential antibacterial activity through high-throughput screening, some of which demonstrated bactericidal effects against both Gram-negative and Gram-positive bacteria. These results provide evidence for the development of potential antibiotics starting compounds.
Article
Chemistry, Multidisciplinary
Hisham S. M. Abd-Rabboh, Abd El-Galil E. Amr, Ahmed M. Naglah, Abdulrahman A. Almehizia, Ayman H. Kamel
Summary: A novel all-solid state screen-printed electrode was developed for chlorogenic acid detection by modifying with multi-walled carbon nanotubes and suitable sensing membrane. The electrode showed Nernstian-response and high sensitivity towards CGA ions in coffee bean extracts and juice samples, demonstrating good stability and selectivity.
Article
Oncology
Roy Moscona, Sanne Marlijn Janssen, Mounib Elchebly, Andreas Ioannis Papadakis, Eitan Rubin, Alan Spatz
Summary: BORIS is a transcription factor that is ectopically expressed in melanoma and contributes to the transition of melanoma cells from an intermediate melanocytic state to a more mesenchymal-like state, leading to increased invasion and tumor progression.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Oncology
Jiahua Xing, Ziqi Jia, Yan Li, Yan Han
Summary: A riskScore model was developed in this study to analyze patient prognosis, immune tumor microenvironment (TME) cell infiltration features, and treatment responsiveness. This model not only aids in predicting patient response to immunotherapy but also has significant implications for the development of novel immunotherapeutic agents and the promotion of tailored treatment regimens.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Gerhard Leinenga, Liviu-Gabriel Bodea, Jan Schroder, Giuzhi Sun, Yichen Zhou, Jae Song, Alexandra Grubman, Jose M. Polo, Jurgen Gotz
Summary: Transcranial scanning ultrasound combined with intravenously injected microbubbles can transiently open the blood-brain barrier and reduce amyloid-beta pathology in an Alzheimer's disease mouse model. The response of microglial cells to this treatment is complex and has potential applications for AD therapy.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Gha-hyun J. Kim, Han Mo, Harrison Liu, Meri Okorie, Steven Chen, Jiashun Zheng, Hao Li, Michelle Arkin, Bo Huang, Su Guo
Summary: This study combines whole organism imaging-based screening and bioinformatic pathway analysis to identify compounds that can improve Parkinson's Disease and uncover previously unknown pathways and targets involved in neuroprotection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Alicia Sanchez-Sanz, Santiago Garcia-Martin, Julia Sabin-Munoz, Irene Moreno-Torres, Victor Elvira, Fatima Al-Shahrour, Aranzazu Garcia-Grande, Elvira Ramil, Ofir de la Fuente, Beatriz Brea-alvarez, Ruth Garcia-Hernandez, Antonio Garcia-Merino, Antonio Jose Sanchez-Lopez
Summary: In this study, the immunophenotypic and transcriptomic changes in peripheral blood mononuclear cells (PBMCs) induced by DMF were investigated, aiming to identify response biomarkers to DMF for multiple sclerosis (MS) treatment. The results showed that responder patients exhibited differences in monocyte and lymphocyte subpopulations, as well as a distinguishable transcriptomic response compared to non-responders. These findings provide insights for the validation of biomarkers for treatment response to DMF.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Marine & Freshwater Biology
Jianguo Lu, Wenyu Fang, Junrou Huang, Shizhu Li
Summary: Genome editing technology has revolutionized the field of life sciences by allowing direct targeting and modification of genomic sequences. With tools like ZFN, TALEN, and CRISPR, researchers have been able to decode genome data and address biological problems. In the realm of aquaculture, fish are not only economically vital but also serve as a crucial link in evolutionary research, making genome editing technologies essential for studying growth, gender, pigmentation traits, and disease modeling in fish species.
MARINE LIFE SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sicheng Song, Jordi Creus Muncunill, Carlos Galicia Aguirre, Kizito-Tshitoko Tshilenge, B. Wade Hamilton, Akos A. Gerencser, Houda Benlhabib, Maria-Daniela Cirnaru, Mark Leid, Sean D. Mooney, Lisa M. Ellerby, Michelle E. Ehrlich
Summary: The dysregulation of striatal gene expression and function is associated with various diseases. The transcription factor BCL11B plays an important role in the function and maintenance of mature medium spiny neurons (MSNs) in the striatum, and its loss of function contributes to the transcriptomic and functional changes in Huntington's disease (HD).
Article
Immunology
Rajia Bahri, Orsolya Kiss, Ian Prise, Karen M. Garcia-Rodriguez, Haris Atmoko, Julia M. Martinez-Gomez, Mitchell P. Levesque, Reinhard Dummer, Michael P. Smith, Claudia Wellbrock, Silvia Bulfone-Paus
Summary: Cutaneous melanoma is a highly aggressive malignancy with increasing incidence. Mast cells (MCs) associated with melanoma stroma (MAMCs) play a role in melanoma development and prognosis through unique gene expression patterns and upregulation of complement component C3.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xavier Minne, Joanna Mbuya Malaika Mutombo, Fatiha Chandad, Roberto D. Fanganiello, Vanessa P. Houde
Summary: This study aimed to investigate the molecular mechanisms involved in the development and progression of periodontitis in an obesogenic microenvironment in response to periodontopathogens. The results showed that the combination of palmitate and Porphyromonas gingivalis enhanced the secretion of pro-inflammatory cytokines and affected genes involved in immune and inflammatory pathways. Therefore, systemic conditions, especially the obesogenic microenvironment, should be considered in the management of periodontal disease in obese patients.