The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1

Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition

(2018) Yuqing Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalance

(2017) Charlotte E. Johnson et al.   Essays in Biochemistry

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

(2017) Shirin Pournourmohammadi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling

(2017) Ahmad Merhi et al.   Scientific Reports

Ammonia exposure induces oxidative stress, endoplasmic reticulum stress and apoptosis in hepatopancreas of pacific white shrimp (Litopenaeus vannamei)

(2016) Zhongxiu Liang et al.   FISH & SHELLFISH IMMUNOLOGY

Ammonia toxicity: from head to toe?

(2016) Srinivasan Dasarathy et al.   METABOLIC BRAIN DISEASE

Nitrogen Regulates AMPK to Control TORC1 Signaling

(2015) Elizabeth Davie et al.   CURRENT BIOLOGY

Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway

(2015) Lingqin Yuan et al.   ENDOCRINE-RELATED CANCER

HEK293 in cell biology and cancer research: phenotype, karyotype, tumorigenicity, and stress-induced genome-phenotype evolution

(2015) A.A. Stepanenko et al.   GENE

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Inducing autophagy

(2014) Lea M Harder et al.   Autophagy

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells

(2014) Jianjun Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

(2014) Daniele Stracka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Autophagy and cell death

(2013) Tohru Yonekawa et al.   Essays in Biochemistry

Autophagy and ammonia

(2012) Heesun Cheong et al.   Autophagy

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Ammonium metabolism in humans

(2012) Maria M. Adeva et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells

(2010) Meng Meng et al.   CELL CYCLE

Mutant p53 mediates survival of breast cancer cells

(2009) L Y Lim et al.   BRITISH JOURNAL OF CANCER

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism