Article
Clinical Neurology
Ji Hee Yu, Regina E. Y. Kim, So Young Park, Da Young Lee, Hyun Joo Cho, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Seong Hwan Kim, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Chol Shin, Nan Hee Kim
Summary: This study found that increased night blood pressure variability (BPV) is associated with reduced brain volume and cognitive decline. High night BPV may be an independent predictor for rapid brain aging in middle-aged population.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Nira Cedres, Patricia Diaz-Galvan, Lucio Diaz-Flores, J-Sebastian Muehlboeck, Yaiza Molina, Jose Barroso, Eric Westman, Daniel Ferreira
Summary: The study found that subjective cognitive decline (SCD) is associated with neurodegeneration in both gray matter and white matter, involving brain areas beyond those typically targeted by Alzheimer's disease. This suggests that SCD may be a sensitive behavioral marker of heterogeneous brain pathologies in individuals recruited from the community.
Article
Clinical Neurology
Maria Janina Wendebourg, Matthias Weigel, Laura Richter, Vanya Gocheva, Patricia Hafner, Anna-Lena Orsini, Valentina Crepulja, Simone Schmidt, Antal Huck, Johanna Oechtering, Maria Blatow, Tanja Haas, Cristina Granziera, Ludwig Kappos, Philippe Cattin, Oliver Bieri, Dirk Fischer, Regina Schlaeger
Summary: This study found that patients with PPS have spinal cord gray matter atrophy, which is associated with muscle strength and functional decline. The results suggest that the atrophy may be due to a secondary neurodegenerative process rather than just aging or residual effects of the initial infection. Longitudinal studies are needed to confirm these findings.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
H. Bejr-kasem, F. Sampedro, J. Marin-Lahoz, S. Martinez-Horta, J. Pagonabarraga, J. Kulisevsky
Summary: In this study, 35.1% of PD patients developed minor hallucinations during follow-up. These patients showed increased prevalence of subjective cognitive decline at 5 years, but not formal cognitive impairment. Additionally, they exhibited differences in gray matter volume at baseline in certain brain regions. Further longitudinal analyses may be needed to determine whether these findings indicate a higher risk of future cognitive deterioration.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Zixiao Zhao, Jie Wang, Ying Wang, Xia Liu, Kun He, Qihao Guo, Fang Xie, Qi Huang, Zijing Li
Summary: This study investigated how influencing factors (risk gene, age, sex, and education) affect amyloid-beta (A β) deposition and gray matter (GM) atrophy in the subjective cognitive decline (SCD) population. The results showed that APOE ε4 gene, age, and sex significantly influenced A β deposition and GM atrophy. These findings are important for identifying SCD individuals at risk for mild cognitive impairment and Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Geriatrics & Gerontology
Patricia Grasso
Summary: This review examines the role of leptin in energy balance, glycemic regulation, and cognitive function, and explores its involvement in maintaining the homeostatic harmony of these physiologies. The effects of exercise on leptin levels and the results of clinical application of leptin to metabolic disease and neurologic dysfunction are summarized. Additionally, pre-clinical evidence suggests the potential use of synthetic peptide leptin mimetics in resolving leptin resistance, insulin resistance in type 2 diabetes, and insulin resistance associated with certain neurologic deficits.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Nicola De Stefano, Antonio Giorgio, Giordano Gentile, Maria Laura Stromillo, Rosa Cortese, Claudio Gasperini, Andrea Visconti, Maria Pia Sormani, Marco Battaglini
Summary: The study aimed to assess the dynamics of pseudo-atrophy in MS patients undergoing anti-inflammatory therapies, showing significantly accelerated brain volume loss in the treated group compared to the placebo group. Additionally, similar changes were observed in patients initially on placebo but later switched to IFN beta-1a treatment. The findings highlight the importance of considering significant GM volume changes in clinical trials using MRI-derived GM volume loss as an outcome measure.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Clinical Neurology
Taro Nakazawa, Tomoyuki Ohara, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Mao Shibata, Takanori Honda, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya
Summary: The study found that lower grey matter volume in regions such as the medial temporal lobe, insula, hippocampus, and amygdala was associated with a higher risk of developing dementia in older Japanese individuals. Additionally, the total number of brain regions showing grey matter atrophy was found to be a significant predictor for dementia, particularly Alzheimer's disease. Incorporating this total number into predictive models improved the ability to forecast the risk of Alzheimer's disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Nutrition & Dietetics
Annamaria Docimo, Ludovica Verde, Luigi Barrea, Claudia Vetrani, Pasqualina Memoli, Giacomo Accardo, Caterina Colella, Gabriella Nosso, Marcello Orio, Andrea Renzullo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the association between chronotype and glycemic control, antidiabetic treatment, and risk of developing complications in patients with type 2 diabetes. The results showed that evening chronotype individuals had higher levels of glycated hemoglobin and fasting plasma glucose, as well as a higher prevalence of cardiovascular complications. Additionally, their glycemic control was poorer. Therefore, controlling chronotype may be important for patients with type 2 diabetes.
Article
Neuroimaging
Xiaoqi Wang, Min Wang, Xiaoni Wang, Feifan Zhou, Jiehui Jiang, Hesheng Liu, Ying Han
Summary: The study found a negative relationship between global amyloid load and GM volume in the amyloid-positive group, with significant interaction effects on GM volume in regions such as the bilateral hemisphere, left temporal cortex, and bilateral frontal cortex. Post hoc analysis revealed a significant association between amyloid and GM volume only in the subgroup with worries, indicating a potential high-risk population for future cognitive decline in preclinical AD cases.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
Eva M. Kesenheimer, Maria Janina Wendebourg, Matthias Weigel, Claudia Weidensteiner, Tanja Haas, Laura Richter, Laura Sander, Antal Horvath, Muhamed Barakovic, Philippe Cattin, Cristina Granziera, Oliver Bieri, Regina Schlaeger
Summary: This study aimed to develop normalization strategies for spinal cord metrics derived from rAMIRA imaging, using skull and spine-based metrics to reduce anatomical variability.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Minh-Phuong Huynh-Le, Michelle D. Tibbs, Roshan Karunamuni, Mia Salans, Kathryn R. Tringale, Anthony Yip, Michael Connor, Aaron B. Simon, Lucas K. Vitzthum, Anny Reyes, Anna Christina Macari, Vitali Moiseenko, Carrie R. McDonald, Jona A. Hattangade-Gluth
Summary: This study analyzed the impact of radiation therapy on cognitive function, particularly attention and processing speed, in primary brain tumor patients. The findings revealed that microstructural injury within the corpus callosum and intrahemispheric white matter tracts was associated with a decline in processing speed.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Clinical Neurology
Tomotaka Shiraishi, Daisuke Yoshimaru, Tadashi Umehara, Masakazu Ozawa, Shusaku Omoto, Motohiro Okumura, Tatsushi Kokubu, Junichiro Takahashi, Takeo Sato, Asako Onda, Teppei Komatsu, Kenichiro Sakai, Hidetaka Mitsumura, Hidetomo Murakami, Hirotaka James Okano, Yasuyuki Iguchi
Summary: Orthostatic hypotension (OH), hyposmia and REM sleep behavior disorder (RBD) are potential risk factors for cognitive impairment in patients with Parkinson's disease (PD). This study investigated how interactions between OH, hyposmia and RBD contribute to gray matter atrophy and cognitive dysfunction in early PD.
JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Martin C. Nwadiugwu, Dhundy R. Bastola, Christian Haas, Doug Russell
Summary: This study analyzed glycemic variability in diabetes patients and found that high glycemic variability was associated with disorders such as lipoprotein abnormalities and electrolyte balance issues, while patients with low glycemic variability showed better health status in factors like screening for other disorders and long-term drug therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Yaqiong Xiao, Liangjun Liao, Kaiyu Huang, Shun Yao, Lei Gao
Summary: This study investigates the relationship between hippocampal volumetric integrity and brain atrophy during AD progression, and finds that hippocampal atrophy is associated with cognitive decline. The study also reveals stronger connections between the hippocampus and other brain regions in MCI and AD patients. These findings have important clinical implications for the prognosis of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Anesthesiology
Chun-Ning Ho, Pei-Han Fu, Jen-Yin Chen, Kuo-Chuan Hung, Jia-Hui Chang, Chung-Kang Peng, Albert C. Yang
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2020)
Article
Mathematics, Interdisciplinary Applications
Xuegeng Mao, Pengjian Shang, Meng Xu, Chung-Kang Peng
CHAOS SOLITONS & FRACTALS
(2020)
Article
Engineering, Mechanical
Xuegeng Mao, Pengjian Shang, Albert C. Yang, Chung-Kang Peng
NONLINEAR DYNAMICS
(2020)
Article
Physics, Multidisciplinary
Xuegeng Mao, Albert C. Yang, Chung-Kang Peng, Pengjian Shang
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2020)
Article
Psychiatry
Wanqing Xie, Chung-Kang Peng, Jihong Shen, Ching-Po Lin, Shih-Jen Tsai, Shujuan Wang, Qianqian Chu, Albert C. Yang
PSYCHIATRY RESEARCH
(2020)
Article
Multidisciplinary Sciences
Cheng-Hsuan Tsai, Hsi-Pin Ma, Yen-Tin Lin, Chi-Sheng Hung, Shan-Hsuan Huang, Bei-Lin Chuang, Chen Lin, Men-Tzung Lo, Chung-Kang Peng, Yen-Hung Lin
SCIENTIFIC REPORTS
(2020)
Article
Physics, Multidisciplinary
Xingran Cui, Leirong Tian, Zhengwen Li, Zikai Ren, Keyang Zha, Xinruo Wei, Chung-Kang Peng
Article
Multidisciplinary Sciences
Peter M. Wayne, Brian J. Gow, Fengzhen Hou, Yan Ma, Jeffrey M. Hausdorff, Justine Lo, Pamela M. Rist, Chung-Kang Peng, Lewis A. Lipsitz, Vera Novak, Brad Manor
Summary: The study explored the association between Tai Chi training and lower extremity muscle co-contraction levels, indicating that long-term Tai Chi training may benefit gait and postural control. Further randomized trials with longer durations and larger sample sizes are needed to evaluate the impact of Tai Chi on neuromuscular coordination.
Article
Clinical Neurology
Jingpeng Sun, Xiyuan Hu, Silong Peng, Chung-Kang Peng, Yan Ma
Summary: This study aimed to classify snores generated at different obstructive sites in the upper airway, showing that snores from various sites differ. By extracting acoustic and physiological features and using machine-learning methods, the model successfully located vibration sites in the upper airway.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Geriatrics & Gerontology
Friedrich Liu, Jong-Ling Fuh, Chung-Kang Peng, Albert C. Yang
Summary: This study found that EEG power is correlated with behavioral and psychological symptoms among patients with mild Alzheimer's disease, especially in the delta wave band. The clustering of patients based on EEG powers showed differences in their behavioral/psychological symptoms.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Physics, Multidisciplinary
Shu-Yu Tang, Hsi-Pin Ma, Chi-Sheng Hung, Ping-Hung Kuo, Chen Lin, Men-Tzung Lo, Hsao-Hsun Hsu, Yu-Wei Chiu, Cho-Kai Wu, Cheng-Hsuan Tsai, Yen-Tin Lin, Chung-Kang Peng, Yen-Hung Lin
Summary: This study investigated the clinical utility of heart rhythm complexity in risk stratification for PH patients, finding that MSE scale 5 can help identify high-risk PH patients. Patients with severe PH had worse heart rhythm complexity.
Article
Psychiatry
Hsin-Jung Tsai, Albert C. Yang, Shih-Jen Tsai, Yan Ma, Terry B. J. Kuo, Cheryl C. H. Yang, Chung-Kang Peng
Summary: This study used two different sleep staging methods and found that the autonomic nervous system is evidently associated with stable sleep, regardless of the sleep staging approach followed.
PSYCHOSOMATIC MEDICINE
(2022)
Letter
Multidisciplinary Sciences
Albert C. Yang, Chung-Kang Peng, Norden E. Huang
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Dan Guo, Robert J. Thomas, Yanhui Liu, Steven A. Shea, Jun Lu, Chung-Kang Peng
Summary: Spontaneous synchronization and de-synchronization of neurons during sleep, especially during slow wave sleep, has been studied. The current sleep classification model based on EEG has overlooked the accompanying physiological changes. Researchers propose a cluster synchronization model to explain the emergence of slow wave sleep in healthy individuals and develop an automated algorithm for sleep stage classification.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Chen-Yu Lin, Shih-Jen Tsai, Chung-Kang Peng, Albert C. Yang
PSYCHIATRY RESEARCH
(2020)