期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 166, 期 1, 页码 24-33出版社
HUMANA PRESS INC
DOI: 10.1007/s12011-015-0298-3
关键词
Transposable element; Retroelement; Heavy metals; Genetic damage
资金
- National Institutes of Health (NIH) [P20GM103518/P20RR020152, R01GM079709A]
Maintenance of genomic integrity is critical for cellular homeostasis and survival. The active transposable elements (TEs) composed primarily of three mobile element lineages LINE-1, Alu, and SVA comprise approximately 30 % of the mass of the human genome. For the past 2 decades, studies have shown that TEs significantly contribute to genetic instability and that TE-caused damages are associated with genetic diseases and cancer. Different environmental exposures, including several heavy metals, influence how TEs interact with its host genome increasing their negative impact. This mini-review provides some basic knowledge on TEs, their contribution to disease, and an overview of the current knowledge on how heavy metals influence TE-mediated damage.
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