Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage

(2018) Vu L. Ngo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eradication of spontaneous malignancy by local immunotherapy

(2018) Idit Sagiv-Barfi et al.   Science Translational Medicine

MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

(2018) Ruchi Jain et al.   Nucleic Acid Therapeutics

Regulation and function of interleukin-36 cytokines

(2017) Esen Yonca Bassoy et al.   IMMUNOLOGICAL REVIEWS

Gene expression markers of Tumor Infiltrating Leukocytes

(2017) Patrick Danaher et al.   Journal for ImmunoTherapy of Cancer

IL-1 family cytokines in cancer immunity – a matter of life and death

(2016) Javier Mora et al.   BIOLOGICAL CHEMISTRY

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic

(2016) Kinga Majchrzak et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting T Cell Co-receptors for Cancer Therapy

(2016) Margaret K. Callahan et al.   IMMUNITY

Common gamma chain cytokines in combinatorial immune strategies against cancer

(2016) Stephanie R. Pulliam et al.   IMMUNOLOGY LETTERS

Intratumoral Delivery of Immunotherapy—Act Locally, Think Globally

(2016) M. Angela Aznar et al.   JOURNAL OF IMMUNOLOGY

Parallels and differences between innate and adaptive lymphocytes

(2016) Sammy Bedoui et al.   NATURE IMMUNOLOGY

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

(2016) Kelly D Moynihan et al.   NATURE MEDICINE

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

(2016) Suzanne I.S. Mosely et al.   Cancer Immunology Research

IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses

(2015) Xuefeng Wang et al.   CANCER CELL

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells

(2015) S. Van Lint et al.   Cancer Immunology Research

The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review

(2015) Simone Punt et al.   OncoImmunology

IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage

(2014) G. L. Stritesky et al.   JOURNAL OF IMMUNOLOGY

IL-36 Promotes Myeloid Cell Infiltration, Activation, and Inflammatory Activity in Skin

(2014) A. M. Foster et al.   JOURNAL OF IMMUNOLOGY

The Dichotomous Pattern of IL-12R and IL-23R Expression Elucidates the Role of IL-12 and IL-23 in Inflammation

(2014) Gaëlle Chognard et al.   PLoS One

Th17 Cells in Cancer: The Ultimate Identity Crisis

(2014) Stefanie R. Bailey et al.   Frontiers in Immunology

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients

(2013) B. D. Curti et al.   CANCER RESEARCH

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

TLR agonists: our best frenemy in cancer immunotherapy

(2013) Sabina Kaczanowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells

(2013) I H Chan et al.   Mucosal Immunology

A balance of interleukin-12 and -23 in cancer

(2013) Shin Foong Ngiow et al.   TRENDS IN IMMUNOLOGY

Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?

(2013) Sonia Carta et al.   Frontiers in Immunology

IL-17-producing γδ T cells and innate lymphoid cells

(2012) Caroline E. Sutton et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting Costimulatory Molecules to Improve Antitumor Immunity

(2012) Daria Capece et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Regulation and function of IL-17A- and IL-22-producing γδ T cells

(2011) Kristin J. Ness-Schwickerath et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rβ2 or IL-18Rα

(2011) I-K Choi et al.   GENE THERAPY

Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity

(2010) Simon S Jensen et al.   Journal of Inflammation-London

Selectivity of Oncolytic Viral Replication Prevents Antiviral Immune Response and Toxicity, but Does Not Improve Antitumoral Immunity

(2010) Engin Gürlevik et al.   MOLECULAR THERAPY

The significance of OX40 and OX40L to T-cell biology and immune disease

(2009) Michael Croft et al.   IMMUNOLOGICAL REVIEWS

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE