Using chemical synthesis to optimise antimicrobial peptides in the fight against antimicrobial resistance

Using Chemical Synthesis to Probe Structure–Activity Relationships of the Glycoactive Bacteriocin Glycocin F

(2018) Sean W. Bisset et al.   ACS Chemical Biology

Total Synthesis and Conformational Study of Callyaerin A: Anti-Tubercular Cyclic Peptide Bearing a Rare Rigidifying (Z )-2,3- Diaminoacrylamide Moiety

(2018) Shengping Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study

(2018) Shimaa A.H. Abdel Monaim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antibacterial studies of teixobactin analogues with non-isostere substitution of enduracididine

(2018) Kang Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus

(2018) Georgina C. Girt et al.   CHEMICAL COMMUNICATIONS

Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin

(2018) Yu Zong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo

(2018) Anish Parmar et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs

(2018) Alicia Boto et al.   MOLECULES

Total chemical synthesis of glycocin F and analogues: S-glycosylation confers improved antimicrobial activity

(2018) Zaid Amso et al.   Chemical Science

An overview of antimicrobial peptides and the latest advances in their development

(2017) Josep M Sierra et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

New tuberculosis drug leads from naturally occurring compounds

(2017) Diana Quan et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP)

(2017) Shimaa A. H. Abdel Monaim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel teixobactin analogues

(2017) Christian E. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding

(2017) Anish Parmar et al.   Chemical Science

Synthesis and structure–activity relationship studies of teixobactin analogues

(2017) Chunlei Wu et al.   RSC Advances

How Membrane-Active Peptides Get into Lipid Membranes

(2016) Marc-Antoine Sani et al.   ACCOUNTS OF CHEMICAL RESEARCH

Elucidation of the Teixobactin Pharmacophore

(2016) Hyunjun Yang et al.   ACS Chemical Biology

Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis

(2016) Darcy J Atkinson et al.   Beilstein Journal of Organic Chemistry

Efficient total syntheses and biological activities of two teixobactin analogues

(2016) Anish Parmar et al.   CHEMICAL COMMUNICATIONS

The glycocins: in a class of their own

(2016) Gillian E Norris et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An analysis of FDA-approved drugs: natural products and their derivatives

(2016) Eric Patridge et al.   DRUG DISCOVERY TODAY

Overexpression of Antimicrobial, Anticancer, and Transmembrane Peptides in Escherichia coli through a Calmodulin-Peptide Fusion System

(2016) Hiroaki Ishida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total chemical synthesis of lassomycin and lassomycin-amide

(2016) S. Lear et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis and Stereochemical Revision of the Anti-Tuberculosis Peptaibol Trichoderin A

(2016) Iman Kavianinia et al.   ORGANIC LETTERS

Total Synthesis of Teixobactin

(2016) Andrew M. Giltrap et al.   ORGANIC LETTERS

Synthesis and activity of a diselenide bond mimetic of the antimicrobial protein caenopore-5

(2016) Karima Medini et al.   Chemical Science

Total synthesis of teixobactin

(2016) Kang Jin et al.   Nature Communications

Lasso Peptides: An Intriguing Class of Bacterial Natural Products

(2015) Julian D. Hegemann et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis of the Antimicrobial S-Linked Glycopeptide, Glycocin F

(2015) Margaret A. Brimble et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bacteriocins and their position in the next wave of conventional antibiotics

(2015) Veronica L. Cavera et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Callyaerins from the Marine Sponge Callyspongia aerizusa: Cyclic Peptides with Antitubercular Activity

(2015) Georgios Daletos et al.   JOURNAL OF NATURAL PRODUCTS

Improved Synthesis of the Unnatural Amino Acids AHMOD and AMD, Components of the Anticancer Peptaibol Culicinin D

(2015) Kwang-Yoon Ko et al.   JOURNAL OF ORGANIC CHEMISTRY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Synthesis and Biological Evaluation of a Teixobactin Analogue

(2015) Yahya E. Jad et al.   ORGANIC LETTERS

Tuberculosis Treatment and Drug Regimens

(2015) G. Sotgiu et al.   Cold Spring Harbor Perspectives in Medicine

The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo

(2014) Wei Gao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical Synthesis of A Pore-Forming Antimicrobial Protein, Caenopore-5, by Using Native Chemical Ligation at a Glu-Cys Site

(2014) Karima Medini et al.   CHEMBIOCHEM

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

(2014) Alimuddin I Zumla et al.   LANCET INFECTIOUS DISEASES

Wollamides: Antimycobacterial Cyclic Hexapeptides from an Australian Soil Streptomyces

(2014) Zeinab G. Khalil et al.   ORGANIC LETTERS

Solid-phase peptide synthesis: an overview focused on the preparation of biologically relevant peptides

(2014) Jose M. Palomo   RSC Advances

Methicillin-Resistant Staphylococcus aureus: An Evolving Pathogen

(2013) M. E. Stryjewski et al.   CLINICAL INFECTIOUS DISEASES

The Glycosyltransferase Involved in Thurandacin Biosynthesis Catalyzes Both O- and S-Glycosylation

(2013) Huan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

(2013) Guilherme Brand et al.   MOLECULES

Stereoselective synthesis of fully protected (2S,4S,6S)-2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (AHMOD)

(2012) Wei Zhang et al.   JOURNAL OF PEPTIDE SCIENCE

Synthesis of the Peptaibol Framework of the Anticancer Agent Culicinin D: Stereochemical Assignment of the AHMOD Moiety

(2012) Kuo-yuan Hung et al.   ORGANIC LETTERS

Action-Mechanism of Trichoderin A, an Anti-dormant Mycobacterial Aminolipopeptide from Marine Sponge-Derived Trichoderma sp.

(2011) Patamaporn Pruksakorn et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

CysteineS-glycosylation, a new post-translational modification found in glycopeptide bacteriocins

(2011) Judith Stepper et al.   FEBS LETTERS

Substrate Selectivity of the Sublancin S-Glycosyltransferase

(2011) Huan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Callyaerins A–F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa

(2010) Sabrin R.M. Ibrahim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

(2010) Patamaporn Pruksakorn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of MethylN-Boc-(2S,4R)-4-methylpipecolate

(2010) Kuo-yuan Hung et al.   JOURNAL OF ORGANIC CHEMISTRY

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

(2010) Neel R Gandhi et al.   LANCET

Caenopores are antimicrobial peptides in the nematode Caenorhabditis elegans instrumental in nutrition and immunity

(2009) Thomas Roeder et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY