Tetramethylpyrazine ameliorates depression by inhibiting TLR4-NLRP3 inflammasome signal pathway in mice

Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis

(2018) Xiangting Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Depression and sterile inflammation: Essential role of danger associated molecular patterns

(2018) Tina C. Franklin et al.   BRAIN BEHAVIOR AND IMMUNITY

Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice

(2018) Jie Cheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Difference in proinflammatory cytokines produced by monocytes between patients with major depressive disorder and healthy controls

(2018) Hong-Xia Zhang et al.   JOURNAL OF AFFECTIVE DISORDERS

Tetramethylpyrazine protects against high glucose-induced vascular smooth muscle cell injury through inhibiting the phosphorylation of JNK, p38MAPK, and ERK

(2018) Yutao Liu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Plasma C-reactive protein levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment

(2018) David Edberg et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Tetramethylpyrazine Protects Against Early Brain Injury and Inhibits the PERK/Akt Pathway in a Rat Model of Subarachnoid Hemorrhage

(2018) Zhengkai Shao et al.   NEUROCHEMICAL RESEARCH

Effects of adjunctive N -acetylcysteine on depressive symptoms: Modulation by baseline high-sensitivity C-reactive protein

(2018) Mauro Porcu et al.   PSYCHIATRY RESEARCH

Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress

(2018) Amal Ahmed Abd El-Fattah et al.   BRAIN RESEARCH

Senegenin exerts anti-depression effect in mice induced by chronic un-predictable mild stress via inhibition of NF-κB regulating NLRP3 signal pathway

(2017) Hongwei Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress

(2017) Ya-Min Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Damage-associated molecular patterns and their role as initiators of inflammatory and auto-immune signals in systemic lupus erythematosus

(2017) Karen Álvarez et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder

(2017) Elísabet Alcocer-Gómez et al.   PHARMACOLOGICAL RESEARCH

Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis

(2017) J-c Zhang et al.   Translational Psychiatry

A novel isoquinoline compound abolishes chronic unpredictable mild stress-induced depressive-like behavior in mice

(2016) Ana Paula Pesarico et al.   BEHAVIOURAL BRAIN RESEARCH

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

(2016) Yuyan Cheng et al.   BRAIN BEHAVIOR AND IMMUNITY

Hesperidin Alleviates Lipopolysaccharide-Induced Neuroinflammation in Mice by Promoting the miRNA-132 Pathway

(2016) Min Li et al.   INFLAMMATION

Integrating neuroimmune systems in the neurobiology of depression

(2016) Eric S. Wohleb et al.   NATURE REVIEWS NEUROSCIENCE

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

(2016) Monika Fleshner et al.   NEUROPSYCHOPHARMACOLOGY

Abnormal gene expression of proinflammatory cytokines and their membrane-bound receptors in the lymphocytes of depressed patients

(2016) Hooriyah S. Rizavi et al.   PSYCHIATRY RESEARCH

Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation

(2016) Min Ma et al.   PSYCHOPHARMACOLOGY

Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice

(2015) Xue-Yang Deng et al.   BEHAVIOURAL BRAIN RESEARCH

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through Promotion of BDNF Signaling Pathway

(2015) Bo Jiang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

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(2015) Huan Yang et al.   MOLECULAR MEDICINE

Resveratrol exerts anti-inflammatory and neuroprotective effects to prevent memory deficits in rats exposed to chronic unpredictable mild stress

(2015) Yusufhan Yazir et al.   PHYSIOLOGY & BEHAVIOR

Effects of polyprenols from pine needles of Pinus massoniana on ameliorating cognitive impairment in a d-galactose-induced mouse model

(2014) Cong Wang et al.   AGE

The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration

(2014) Zhen Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammasomes in neuroinflammation and changes in brain function: a focused review

(2014) Gaurav Singhal et al.   Frontiers in Neuroscience

Chronic Administration of Infliximab (TNF-α Inhibitor) Decreases Depression and Anxiety-like Behaviour in Rat Model of Chronic Mild Stress

(2013) Ayşe Karson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

Toll-like Receptor 4 (TLR4) Is Essential for Hsp70-like Protein 1 (HSP70L1) to Activate Dendritic Cells and Induce Th1 Response

(2011) Hongliang Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells

(2011) Dexiang Liu et al.   NEUROPHARMACOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Nuclear factor- B is a critical mediator of stress-impaired neurogenesis and depressive behavior

(2010) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DAMPs and inflammatory processes: the role of redox in the different outcomes

(2009) Sonia Carta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress

(2008) D.D. Luo et al.   BRAIN RESEARCH BULLETIN

Major Depressive Disorder

(2008) R.H. Belmaker et al.   NEW ENGLAND JOURNAL OF MEDICINE