ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

Targeting lysyl oxidase reduces peritoneal fibrosis

(2017) Christopher R. Harlow et al.   PLoS One

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

(2017) HaoRan Tang et al.   Nature Communications

Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

(2017) Joan Chang et al.   Oncotarget

Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases

(2017) Chen Rachman-Tzemah et al.   Cell Reports

A Role for The ATP7A Copper Transporter in Tumorigenesis and Cisplatin Resistance

(2017) Sha Zhu et al.   Journal of Cancer

Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis

(2017) Verena Aumiller et al.   Scientific Reports

Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis

(2016) Thomas R. Cox et al.   CANCER RESEARCH

Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases

(2016) Nancy Chan et al.   CLINICAL CANCER RESEARCH

Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma

(2014) Carmen Chak-Lui Wong et al.   HEPATOLOGY

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

(2013) S. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling

(2012) Cheng-Yu Tsai et al.   BIOCHEMICAL PHARMACOLOGY

Charting the travels of copper in eukaryotes from yeast to mammals

(2012) Tracy Nevitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway

(2012) Li-Ching Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

Membrane Transporters as Determinants of the Pharmacology of Platinum Anticancer Drugs

(2012) Johnson J. Liu et al.   CURRENT CANCER DRUG TARGETS

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

(2012) M. L. Turski et al.   MOLECULAR AND CELLULAR BIOLOGY

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells

(2012) XIAOXIAO YANG et al.   ONCOLOGY REPORTS

The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer

(2011) Ann-Marie Baker et al.   JNCI-Journal of the National Cancer Institute

ATP7A-related copper transport diseases—emerging concepts and future trends

(2011) Stephen G. Kaler   Nature Reviews Neurology

Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects

(2010) Begoña López et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Focal adhesion kinase-dependent regulation of adhesive forces involves vinculin recruitment to focal adhesions

(2009) David W. Dumbauld et al.   BIOLOGY OF THE CELL

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes

(2008) Subba Rao Gangi Setty et al.   NATURE