Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

Speed dependent descending control of freezing behavior in Drosophila melanogaster

(2018) Ricardo Zacarias et al.   Nature Communications

A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter

(2017) Asghar M. Razavi et al.   Scientific Reports

A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state

(2016) Lina Malinauskaite et al.   Nature Communications

Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus

(2015) George Khelashvili et al.   ACS Chemical Neuroscience

Behavioral Responses to a Repetitive Visual Threat Stimulus Express a Persistent State of Defensive Arousal in Drosophila

(2015) William T. Gibson et al.   CURRENT BIOLOGY

Recent Advances in the Genetics of Autism Spectrum Disorder

(2015) Silvia De Rubeis et al.   Current Neurology and Neuroscience Reports

Gene hunting in autism spectrum disorder: on the path to precision medicine

(2015) Daniel H Geschwind et al.   LANCET NEUROLOGY

Neurotransmitter and psychostimulant recognition by the dopamine transporter

(2015) Kevin H. Wang et al.   NATURE

Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter

(2015) Mary Hongying Cheng et al.   STRUCTURE

Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors

(2015) Etienne Cartier et al.   EBioMedicine

PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein

(2014) Peter J Hamilton et al.   Nature Chemical Biology

Conformational dynamics of ligand-dependent alternating access in LeuT

(2014) Kelli Kazmier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking

(2014) E Bowton et al.   Translational Psychiatry

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

(2013) P J Hamilton et al.   MOLECULAR PSYCHIATRY

Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae

(2013) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate

(2013) F. Buchmayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Analysis of the High-Affinity Zinc Binding Site Validates a Refined Human Dopamine Transporter Homology Model

(2013) Thomas Stockner et al.   PLoS Computational Biology

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

(2012) Harini Krishnamurthy et al.   NATURE

Patterns and rates of exonic de novo mutations in autism spectrum disorders

(2012) Benjamin M. Neale et al.   NATURE

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context

(2012) Hui Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Modular Toolset for Recombination Transgenesis and Neurogenetic Analysis of Drosophila

(2012) Ji-Wu Wang et al.   PLoS One

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Increased Sensitivity and Extended Range of Distance Measurements in Spin-Labeled Membrane Proteins: Q-Band Double Electron-Electron Resonance and Nanoscale Bilayers

(2010) Ping Zou et al.   BIOPHYSICAL JOURNAL

g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation

(2010) Maarten G. Wolf et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters

(2010) Derek P Claxton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Simons Simplex Collection: A Resource for Identification of Autism Genetic Risk Factors

(2010) Gerald D. Fischbach et al.   NEURON

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP

(2009) Jill L Silverman et al.   NEUROPSYCHOPHARMACOLOGY

Currents in Response to Rapid Concentration Jumps of Amphetamine Uncover Novel Aspects of Human Dopamine Transporter Function

(2008) K. Erreger et al.   JOURNAL OF NEUROSCIENCE

Mechanism for alternating access in neurotransmitter transporters

(2008) L. R. Forrest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation

(2008) S. K. Singh et al.   SCIENCE