Neurotransmitter and psychostimulant recognition by the dopamine transporter

Computational and Biochemical Docking of the Irreversible Cocaine Analog RTI 82 Directly Demonstrates Ligand Positioning in the Dopamine Transporter Central Substrate-binding Site

(2014) Rejwi Acharya Dahal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

Conformational dynamics of ligand-dependent alternating access in LeuT

(2014) Kelli Kazmier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

(2014) Lina Malinauskaite et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation

(2014) Yvette Dehnes et al.   NEUROCHEMISTRY INTERNATIONAL

The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants

(2014) M. A. Mergy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermostabilisation of the Serotonin Transporter in a Cocaine-Bound Conformation

(2013) Saba Abdul-Hussein et al.   JOURNAL OF MOLECULAR BIOLOGY

SLC6 transporters: Structure, function, regulation, disease association and therapeutics

(2013) Akula Bala Pramod et al.   MOLECULAR ASPECTS OF MEDICINE

Structural basis for action by diverse antidepressants on biogenic amine transporters

(2013) Hui Wang et al.   NATURE

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Comparative Modeling of the Human Monoamine Transporters: Similarities in Substrate Binding

(2012) Heidi Koldsø et al.   ACS Chemical Neuroscience

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Interaction of Antidepressants with the Serotonin and Norepinephrine Transporters

(2012) Lena Sørensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

(2012) Harini Krishnamurthy et al.   NATURE

Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP

(2012) Camilo Perez et al.   NATURE

Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice

(2012) Gunnar Sørensen et al.   PSYCHOPHARMACOLOGY

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

(2011) Yongfang Zhao et al.   NATURE

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

(2011) A. S. Kristensen et al.   PHARMACOLOGICAL REVIEWS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Membrane Cholesterol Modulates the Outward Facing Conformation of the Dopamine Transporter and Alters Cocaine Binding

(2010) Weimin C. Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters

(2010) Derek P Claxton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The binding sites for benztropines and dopamine in the dopamine transporter overlap

(2010) Heidi Bisgaard et al.   NEUROPHARMACOLOGY

Amphetamine and Methamphetamine Differentially Affect Dopamine Transportersin Vitroandin Vivo

(2008) J. Shawn Goodwin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The binding sites for cocaine and dopamine in the dopamine transporter overlap

(2008) Thijs Beuming et al.   NATURE NEUROSCIENCE

A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation

(2008) S. K. Singh et al.   SCIENCE

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

(2008) S. Weyand et al.   SCIENCE