Review
Biochemistry & Molecular Biology
Shean-Jaw Chiou, Huey-Jiun Ko, Chi-Ching Hwang, Yi-Ren Hong
Summary: Beta2-microglobulin (B2M) plays a crucial role in both immune response and antimicrobial activity, functioning primarily in innate defense. B2M acts as an antimicrobial peptide under acidic conditions, disrupting a wide range of microbes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Aleksey D. Drozdov, Jesper deClaville Christiansen
Summary: The increase in elastic modulus is associated with aggregation of hydrophobic segments into clusters, forming extra physical bonds between chains. Microgels exhibit higher elastic moduli but lower degrees of swelling in stress-free state compared with macroscopic gels.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Polymer Science
Lin Xu, Samuel C. Lamont, Tao Li, Ying Zhang, Wenlong Pan, Chongyi Gao, Chen Zhu, Si Chen, Hongwei Hu, Jianning Ding, Franck J. Vernerey
Summary: We investigated the mechanical properties of a magnetic temperature-sensitive hydrogel with varying concentrations of covalent and physical cross-linking. Increasing the nanoclay content improved both strength and toughness in the double network materials due to the strong viscoplastic behavior of the physical nanoclay network. Our findings suggest that the yield-stress behavior of the nanoclay network and load-sharing interactions between the PNIPAAm and nanoclay are responsible for the observed trends. Additionally, we found a strong correlation between the mass ratio of covalent cross-linker used and fractional percolation of the PNIPAAm network.
Article
Biochemical Research Methods
Elena A. Ermakova, Olga N. Makshakova, Yuriy F. Zuev, Igor A. S. Sedov
Summary: The study simulated the unfolding of the amyloidogenic fragment of HEWL, revealing the formation of novel structures during the process that can contribute to the assembly of oligomers and propagate into fibril-like forms.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2021)
Article
Chemistry, Multidisciplinary
Lanlan Yu, Ruonan Wang, Shucong Li, Ufuoma I. Kara, Eric C. Boerner, Boyuan Chen, Feiyi Zhang, Zhongyi Jian, Shuyuan Li, Mingwei Liu, Yang Wang, Shuli Liu, Yanlian Yang, Chen Wang, Wenbo Zhang, Yuxing Yao, Xiaoguang Wang, Chenxuan Wang
Summary: Scanning tunneling microscopy (STM) is used to distinguish 18 coexisting conformational substates of the β-strand of hIAPP 8-37 and analyze the peptide-peptide interactions. This method also validates the existence of multiple conformations in other β-sheet peptide assemblies. The results provide insights into the conformational ensemble and interpeptide interactions in β-sheet peptide assembly.
ACS CENTRAL SCIENCE
(2023)
Article
Polymer Science
Carlos Noble Jesus, Rhys Evans, Joe Forth, Carolina Estarellas, Francesco Luigi Gervasio, Giuseppe Battaglia
Summary: The study presents the design, simulation, synthesis, and reversible self-assembly of nanofibrils using polyhistidine-based oligopeptides. The inclusion of aromatic amino acids in the histidine block leads to the formation of amyloid-like fibrils with distinct antiparallel beta-strands. The structures undergo self-assembly in response to pH changes, offering potential for biotechnological and biomedical applications with pH-responsive fibrils in a physiologically relevant range.
Article
Agriculture, Multidisciplinary
Yuran Zhang, Derek R. Dee
Summary: Upon heating at low pH, legume seed storage proteins can form amyloid fibrils, which could enhance their functionality for various applications. Using LC-MS/MS, we identified the amyloid core regions of peptide fibrils formed by enriched pea and soy globulins, and investigated their hydrolysis, assembly kinetics, and morphology. Our findings revealed that pea and soy 7S globulins did not display a lag phase during fibrillation kinetics, while 11S globulins and crude extracts did. Pea and soy protein fibrils exhibited distinct morphologies, with pea fibrils being straight and soy fibrils being worm-like. Furthermore, we identified numerous amyloid-forming peptides from pea and soy globulins, suggesting that these proteins are rich in amyloidogenic regions. This study provides insights into the fibrillation mechanism of legume globulins and has implications for engineering protein fibrils with specific properties and functions.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qiantao Song, Yi Li, Zhicheng Jin, Hai Liu, Matthew N. Creyer, Wonjun Yim, Yanping Huang, Xiaobing Hu, Tengyu He, Yajuan Li, Shana O. Kelley, Lingyan Shi, Jiajing Zhou, Jesse V. Jokerst
Summary: This study reports the mild and unique formation of luminescent spherulites at room temperature using benzene-1,4-dithiol. These spherulites not only exhibit robust structure but also show broad clusterization-triggered emission. They also demonstrate biocompatibility and efficient cellular uptake, making them valuable as traceable drug carriers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemical Research Methods
Mantas Ziaunys, Kamile Mikalauskaite, Andrius Sakalauskas, Vytautas Smirnovas
Summary: The aggregation of amyloidogenic proteins is related to various diseases, with limited treatment options currently available. The challenge in the discovery of potential anti-amyloid molecules lies in identifying the actual inhibitors from complex mixtures. This study successfully scavenged potential aggregation-inhibiting molecules from different compounds and effectively separated them from the aggregates.
BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Tongtong Hou, Nan Zhang, Chaoren Yan, Minling Ding, Huizhe Niu, Ping Guan, Xiaoling Hu
Summary: This study developed a curcumin lysozyme-imprinted nanosphere (CUR-MIMS) that effectively inhibited the aggregation of lysozyme and showed good biocompatibility, demonstrating its potential as a therapeutic platform for amyloidosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Jian Yeo, Gihyun Lee, Sujeong Lee, Moonhyun Oh
Summary: This study presents a convenient method for the selective construction of yolk-shell or core-shell-type hybrid metal oxide double layers, using silica-templated coordination polymer layers. The different structures formed are controlled by the thermal decomposition properties of the layers, with the thickness of the inner polymer layer modulating the space between the yolk and shell metal oxides.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Mantas Ziaunys, Andrius Sakalauskas, Tomas Sneideris, Vytautas Smirnovas
Summary: Protein aggregation into amyloid fibrils is associated with various disorders, but the mechanisms behind the conversion of non-harmful proteins into such aggregates are not fully understood. Recent studies suggest that multiple types of protein aggregates may co-exist in tissues of patients with amyloid-related disorders, potentially influencing each other.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Jozef Adamcik, Francesco Simone Ruggeri, Joshua T. Berryman, Afang Zhang, Tuomas P. J. Knowles, Raffaele Mezzenga
Summary: The nanomechanical properties and structural transitions of amyloid fibrils and microcrystals can be unraveled at the single aggregate scale using single molecule nanomechanical mapping and infrared nanospectroscopy techniques. Different morphologies of amyloid aggregates exhibit varying Young's moduli, with stiffness correlated to the content of intermolecular hydrogen bonding and the structure transition process.
Article
Chemistry, Multidisciplinary
Jiangtao Zhou, Ting Li, Mohammad Peydayesh, Mattia Usuelli, Viviane Lutz-Bueno, Jie Teng, Li Wang, Raffaele Mezzenga
Summary: Amyloid functional materials derived from oat globulin show diverse functionalities with rich polymorphism, reversible and irreversible fibrillization processes. These materials can be applied in water purification, sensors, and electrodes, with demonstrated sustainability against other protein sources for environmentally-efficient advanced materials and technologies.
Article
Optics
Sony Udayan, R. Lakshmi, B. Anugop, P. P. Saipriya, Ajith Vengellur, M. Kailasnath, V. P. N. Nampoori, Sheenu Thomas
Summary: The lasing characteristics of near infrared hemicyanine laser dye LDS 821 in different bio-nanotemplates were studied, showing promising results in DNA-surfactant complex and lysozyme amyloid fibrils. The well-resolved resonant modes and lower lasing threshold observed in these bio-nanotemplates suggest their potential use in biolaser fabrication. Random lasing behavior in lysozyme amyloid fibrils indicates the complexity of the lasing process in this system.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yiping Cao, Shugang Li, Yapeng Fang, Katsuyoshi Nishinari, Glyn O. Phillips
Article
Evolutionary Biology
Shugang Li, Yiping Cao, Fang Geng
EVOLUTIONARY BIOINFORMATICS
(2017)
Article
Chemistry, Applied
Zhiming Gao, Yapeng Fang, Yiping Cao, Hua Liao, Katsuyoshi Nishinari, Glyn O. Phillips
FOOD HYDROCOLLOIDS
(2017)
Article
Biochemistry & Molecular Biology
Yiping Cao, Shugang Li, Yapeng Fang, Katsuyoshi Nishinari, Glyn O. Phillips, Adrien Lerbret, Ali Assifaoui
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Physics, Multidisciplinary
Yiping Cao, Sreenath Bolisetty, Jozef Adamcik, Raffaele Mezzenga
PHYSICAL REVIEW LETTERS
(2018)
Article
Multidisciplinary Sciences
Yiping Cao, Yapeng Fang, Katsuyoshi Nishinari, Glyn O. Phillips
SCIENTIFIC REPORTS
(2016)
Article
Chemistry, Multidisciplinary
Qingrui Zhang, Sreenath Bolisetty, Yiping Cao, Stephan Handschin, Jozef Adamcik, Qiuming Peng, Raffaele Mezzenga
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Physical
Tom Brenner, Rando Tuvikene, Yiping Cao, Yapeng Fang, Masahiro Rikukawa, William S. Price, Shingo Matsukawa
EUROPEAN PHYSICAL JOURNAL E
(2019)
Article
Chemistry, Physical
Yiping Cao, Raffaele Mezzenga
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2019)
Article
Polymer Science
Mattia Usuelli, Yiping Cao, Massimo Bagnani, Stephan Handschin, Gustav Nystrom, Raffaele Mezzenga
Article
Chemistry, Multidisciplinary
Yangyang Han, Yiping Cao, Sreenath Bolisetty, Tian Tian, Stephan Handschin, Canhui Lu, Raffaele Mezzenga
Article
Chemistry, Multidisciplinary
Yiping Cao, Jozef Adamcik, Michael Diener, Janet R. Kumita, Raffaele Mezzenga
Summary: The propensity of proteins to self-assemble into amyloid fibrils with a shared cross-beta architecture is common, but the irreversibility and stability of amyloid fibrils make amyloid-related diseases difficult to treat. Recent studies suggest that certain proteins with low-complexity domains may form labile amyloids. Research shows that reversible and irreversible amyloid fibrils formed from the same full-length protein sequence have differences in core structures and beta-sheet arrangements, highlighting the role of protein folding states in regulating amyloid lability and reversibility.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Mattia Usuelli, Till Germerdonk, Yiping Cao, Mohammad Peydayesh, Massimo Bagnani, Stephan Handschin, Gustav Nystrom, Raffaele Mezzenga
Summary: A simple and sustainable approach is presented in this work to reinforce amyloid fibril hydrogels and aerogels by diffusing polysaccharides inside, resulting in materials with enhanced resistance to compression without compromising the exquisite surface reactivity of amyloid fibrils. This proposed method can lead to the design of composite materials that are both highly functional and environmentally friendly.
Review
Food Science & Technology
Yiping Cao, Raffaele Mezzenga