Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome

Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice

(2018) Charlotte Girard-Guyonvarc’h et al.   BLOOD

Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome

(2018) Eric S. Weiss et al.   BLOOD

Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic Arthritis

(2018) Grant S. Schulert et al.   ARTHRITIS CARE & RESEARCH

Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition

(2017) Scott W. Canna et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Personalized Diagnostic and Treatment Approach for Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Adults

(2017) Bharat Kumar et al.   JOURNAL OF CLINICAL IMMUNOLOGY

How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis

(2017) Ellen Brisse et al.   Frontiers in Immunology

Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

(2016) Claudia Bracaglia et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

(2016) Bita Shakoory et al.   CRITICAL CARE MEDICINE

Macrophage activation syndrome complicating adult onset Still’s disease: A single center case series and comparison with literature

(2016) Aleksander Lenert et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborat

(2016) Angelo Ravelli et al.   Arthritis & Rheumatology

Marked hyperferritinemia does not predict for HLH in the adult population

(2015) A. M. Schram et al.   BLOOD

How I treat hemophagocytic lymphohistiocytosis in the adult patient

(2015) A. M. Schram et al.   BLOOD

Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents

(2015) Kai Lehmberg et al.   BRITISH JOURNAL OF HAEMATOLOGY

The development and evaluation of an evidence-based guideline programme to improve care in a paediatric emergency department

(2015) Ayobami T Akenroye et al.   EMERGENCY MEDICINE JOURNAL

Familial Hemophagocytic Lymphohistiocytosis

(2015) Barbara Degar   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Evaluating the optimal serum ferritin level to identify hemophagocytic lymphohistiocytosis in the critical care setting

(2015) Hayder Saeed et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza

(2015) Grant S. Schulert et al.   JOURNAL OF INFECTIOUS DISEASES

Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis under Treatment with Tocilizumab

(2015) S. Yokota et al.   JOURNAL OF RHEUMATOLOGY

Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ

(2015) Karen Put et al.   RHEUMATOLOGY

Identification of the best cutoff points and clinical signs specific for early recognition of macrophage activation syndrome in active systemic juvenile idiopathic arthritis

(2015) Mikhail M. Kostik et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Inhibition of Natural Killer Cell Cytotoxicity by Interleukin-6: Implications for the Pathogenesis of Macrophage Activation Syndrome

(2015) Loredana Cifaldi et al.   Arthritis & Rheumatology

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Determination of an appropriate cut-off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis

(2014) Kai Lehmberg et al.   PEDIATRIC BLOOD & CANCER

Therapeutic Role of Anakinra, an Interleukin-1 Receptor Antagonist, in the Management of Secondary Hemophagocytic Lymphohistiocytosis/Sepsis/Multiple Organ Dysfunction/Macrophage Activating Syndrome in Critically Ill Children*

(2014) Surender Rajasekaran et al.   Pediatric Critical Care Medicine

Mutations of familial hemophagocytic lymphohistiocytosis (FHL) related genes and abnormalities of cytotoxicity function tests in patients with macrophage activation syndrome (MAS) occurring in systemic juvenile idiopathic arthritis (sJIA)

(2014) Claudia Bracaglia et al.   Pediatric Rheumatology

Fulminant myocarditis and macrophage activation syndrome secondary to adult-onset Still’s disease successfully treated with tocilizumab

(2014) Eimear Savage et al.   RHEUMATOLOGY

Whole-Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis

(2014) Kenneth M. Kaufman et al.   Arthritis & Rheumatology

Performance of Current Guidelines for Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

(2014) Sergio Davì et al.   Arthritis & Rheumatology

Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy

(2013) D. T. Teachey et al.   BLOOD

Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency

(2013) Taizo Wada et al.   CYTOKINE

Higher-dose Anakinra Is Effective in a Case of Medically Refractory Macrophage Activation Syndrome

(2013) P. J. KAHN et al.   JOURNAL OF RHEUMATOLOGY

Tocilizumab masks the clinical symptoms of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: The diagnostic significance of interleukin-18 and interleukin-6

(2012) Masaki Shimizu et al.   CYTOKINE

Rapid and Sustained Remission of Systemic Juvenile Idiopathic Arthritis-Associated Macrophage Activation Syndrome Through Treatment With Anakinra and Corticosteroids

(2012) Normi Bruck et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH

(2011) K. Zhang et al.   BLOOD

Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in mice

(2011) Edward M. Behrens et al.   JOURNAL OF CLINICAL INVESTIGATION

Methods of Formal Consensus in Classification/Diagnostic Criteria and Guideline Development

(2011) Raj Nair et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Macrophage Activation Syndrome Treated with Anakinra

(2010) M. DURAND et al.   JOURNAL OF RHEUMATOLOGY

Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patients

(2010) P. M. Miettunen et al.   RHEUMATOLOGY

Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis

(2010) M. Shimizu et al.   RHEUMATOLOGY

Hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis: a journey of a thousand miles begins with a single (big) step

(2008) M B Jordan et al.   BONE MARROW TRANSPLANTATION

Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis

(2007) Carl E. Allen et al.   PEDIATRIC BLOOD & CANCER