Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine

5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

(2018) Yao Peng et al.   CELL

KAMO: towards automated data processing for microcrystals

(2018) Keitaro Yamashita et al.   Acta Crystallographica Section D-Structural Biology

Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist

(2018) Wanchao Yin et al.   Cell Discovery

Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

(2018) Sheng Wang et al.   NATURE

The US Food and Drug Administration’s Perspective on the New Antipsychotic Pimavanserin

(2017) Mitchell V. Mathis et al.   JOURNAL OF CLINICAL PSYCHIATRY

Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A: Identification of Thermostabilizing Mutations Followed by Determination of Three-Dimensional Structures for Two Example Receptors

(2017) Satoshi Yasuda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The 5-HT2A serotonin receptor in executive function: Implications for neuropsychiatric and neurodegenerative diseases

(2016) Susana Aznar et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Generic GPCR residue numbers – aligning topology maps while minding the gaps

(2015) Vignir Isberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

On the Discovery and Development of Pimavanserin: A Novel Drug Candidate for Parkinson’s Psychosis

(2014) Uli Hacksell et al.   NEUROCHEMICAL RESEARCH

Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography

(2013) James Foadi et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Second Generation Antipsychotic-Induced Type 2 Diabetes: A Role for the Muscarinic M3 Receptor

(2013) Katrina Weston-Green et al.   CNS DRUGS

5-Hydroxytryptamine 2A receptor antagonists as potential treatment for psychiatric disorders

(2013) Tiago A Mestre et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype–targeted drugs

(2013) Herbert Y. Meltzer et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

The role of serotonin receptors in the action of atypical antipsychotic drugs

(2011) HY Meltzer et al.   CURRENT OPINION IN PHARMACOLOGY

Structure of the human histamine H1 receptor complex with doxepin

(2011) Tatsuro Shimamura et al.   NATURE

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

Serotonin Receptors

(2008) David E. Nichols et al.   CHEMICAL REVIEWS

Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure

(2007) Christopher B. Roth et al.   JOURNAL OF MOLECULAR BIOLOGY