Developmental origins and emerging therapeutic opportunities for childhood cancer

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

(2018) Kristian W. Pajtler et al.   ACTA NEUROPATHOLOGICA

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1

(2018) Charlotta Böiers et al.   DEVELOPMENTAL CELL

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information

(2018) Christian Koelsche et al.   MODERN PATHOLOGY

The landscape of genomic alterations across childhood cancers

(2018) Susanne N. Gröbner et al.   NATURE

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas

(2018) Christopher W. Mount et al.   NATURE MEDICINE

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

(2018) Mariella G. Filbin et al.   SCIENCE

Trametinib for progressive pediatric low-grade gliomas

(2018) Maria Kondyli et al.   JOURNAL OF NEURO-ONCOLOGY

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

(2018) Xiaotu Ma et al.   NATURE

Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

(2018) Jon D. Larson et al.   CANCER CELL

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model

(2018) Xi Feng et al.   eLife

Bone marrow drives central nervous system regeneration after radiation injury

(2017) Jorg Dietrich et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

(2017) Stephen C. Mack et al.   NATURE

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

(2017) Meera Murgai et al.   NATURE MEDICINE

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

(2017) Andrea Piunti et al.   NATURE MEDICINE

A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study

(2017) Anuradha Banerjee et al.   NEURO-ONCOLOGY

Wrapped to Adapt: Experience-Dependent Myelination

(2017) Christopher W. Mount et al.   NEURON

Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma

(2017) Stefan K. Zöllner et al.   Science Signaling

Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development

(2017) Jeremie Vitte et al.   Nature Communications

Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma

(2017) Stefan K. Zöllner et al.   Science Signaling

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Adaptive myelination from fish to man

(2016) Marion Baraban et al.   BRAIN RESEARCH

Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

(2016) Xi Feng et al.   Journal of Neuroinflammation

A meta-analysis of the neuropsychological effects of chemotherapy in the treatment of childhood cancer

(2016) Cory Pierson et al.   PEDIATRIC BLOOD & CANCER

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

(2016) J. Bayliss et al.   Science Translational Medicine

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

(2016) Zhi-Yan Han et al.   Nature Communications

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes

(2015) Sheila R. Alcantara Llaguno et al.   CANCER CELL

Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53

(2015) Jessica M.Y. Ng et al.   CANCER RESEARCH

Stem Cell Transplantation Reverses Chemotherapy-Induced Cognitive Dysfunction

(2015) M. M. Acharya et al.   CANCER RESEARCH

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia

(2015) Min Ye et al.   Cell Stem Cell

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches

(2015) Shelby C. Peterson et al.   Cell Stem Cell

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

(2015) Catherine S Grasso et al.   NATURE MEDICINE

Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

(2015) Sigrid Mensch et al.   NATURE NEUROSCIENCE

Neuronal activity biases axon selection for myelination in vivo

(2015) Jacob H Hines et al.   NATURE NEUROSCIENCE

Diffusion tensor imaging and neurocognition in survivors of childhood acute lymphoblastic leukaemia

(2014) Michelle N. Edelmann et al.   BRAIN

Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma

(2014) Rachelle E. Stopczynski et al.   CANCER RESEARCH

Low-doses of cisplatin injure hippocampal synapses: A mechanism for ‘chemo’ brain?

(2014) Adrienne L. Andres et al.   EXPERIMENTAL NEUROLOGY

Postnatal growth of the human pons: A morphometric and immunohistochemical analysis

(2014) Matthew C. Tate et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Strategy for “Detoxification” of a Cancer-Derived Histone Mutant Based on Mapping Its Interaction with the Methyltransferase PRC2

(2014) Zachary Z. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

(2014) S. C. Mack et al.   NATURE

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

(2014) Gang Wu et al.   NATURE GENETICS

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

(2014) Rintaro Hashizume et al.   NATURE MEDICINE

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

(2014) Kosuke Funato et al.   SCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

(2014) Brenton G. Mar et al.   Nature Communications

Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

(2013) Sebastian Bender et al.   CANCER CELL

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

(2013) Sam Behjati et al.   NATURE GENETICS

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

Effects of chemotherapy on the brain in childhood: diffusion tensor imaging of subtle white matter damage

(2013) Shigemi Morioka et al.   NEURORADIOLOGY

Motor functioning during and following treatment with chemotherapy for pediatric acute lymphoblastic leukemia

(2013) Jessica L. Green et al.   PEDIATRIC BLOOD & CANCER

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma

(2012) Adrian M. Dubuc et al.   ACTA NEUROPATHOLOGICA

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

(2012) Dong-Anh Khuong-Quang et al.   ACTA NEUROPATHOLOGICA

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

(2012) A V Krivtsov et al.   LEUKEMIA

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

IDH1 and IDH2 mutations in pediatric acute leukemia

(2011) A K Andersson et al.   LEUKEMIA

Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group

(2011) K. J. Cohen et al.   NEURO-ONCOLOGY

Diffusion tensor imaging of white matter tract evolution over the lifespan

(2011) C. Lebel et al.   NEUROIMAGE

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma

(2011) M. Monje et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis

(2010) S. M. Knox et al.   SCIENCE

Outcome and prognostic features in pediatric gliomas

(2009) Ibrahim Qaddoumi et al.   CANCER

Prospective Evaluation of Radiotherapy With Concurrent and Adjuvant Temozolomide in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma

(2009) Rakesh Jalali et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Neurocognitive status in long-term survivors of childhood CNS malignancies: A report from the Childhood Cancer Survivor Study.

(2009) Leah Ellenberg et al.   NEUROPSYCHOLOGY

Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia

(2008) D. Hong et al.   SCIENCE