Article
Endocrinology & Metabolism
Stephen E. Gitelman, Brian N. Bundy, Ele Ferrannini, Noha Lim, J. Lori Blanchfield, Linda A. DiMeglio, Eric Felner, Jason L. Gaglia, Peter A. Gottlieb, S. Alice Long, Andrea Mari, Raghavendra G. Mirmira, Philip Raskin, Srinath Sanda, Eva Tsalikian, John M. Wentworth, Steven M. Willi, Jeffrey P. Krischer, Jeffrey A. Bluestone
Summary: Imatinib was shown to preserve beta-cell function at 12 months in patients with recent-onset type 1 diabetes, but the effect was not sustained at 24 months. Adverse events were more common in the imatinib group compared to the placebo group, with gastrointestinal issues and laboratory investigations being the most commonly reported. Further research is needed to determine the ideal dose and duration of therapy, safety and efficacy in children, and the potential of imatinib to delay or prevent progression to diabetes.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Rheumatology
Pascal Richette, Augustin Latourte, Jeremie Sellam, Daniel Wendling, Muriel Piperno, Philippe Goupille, Yves-Marie Pers, Florent Eymard, Sebastien Ottaviani, Paul Ornetti, Rene-Marc Flipo, Bruno Fautrel, Olivier Peyr, Jean Pierre Bertola, Eric Vicaut, Xavier Chevalier
Summary: The study found that tocilizumab was not more effective than placebo in relieving pain in patients with hand osteoarthritis. Apart from the primary endpoint, there were no significant differences in secondary outcomes between the tocilizumab group and the placebo group.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Brad H. Rovin, Y. K. Onno Teng, Ellen M. Ginzler, Cristina Arriens, Dawn J. Caster, Juanita Romero-Diaz, Keisha Gibson, Joshua Kaplan, Laura Lisk, Sandra Navarra, Samir V. Parikh, Simrat Randhawa, Neil Solomons, Robert B. Huizinga
Summary: This study evaluated the efficacy and safety of voclosporin for the treatment of lupus nephritis, showing a superior complete renal response rate with voclosporin in combination with MMF and low-dose steroids compared to MMF and low-dose steroids alone. The safety profile was comparable between the two groups. This finding represents an important advancement in the treatment of patients with active lupus nephritis.
Article
Medicine, General & Internal
Andrew W. Horne, Stephen Tong, Catherine A. Moakes, Lee J. Middleton, W. Colin Duncan, Ben W. Mol, Lucy H. R. Whitaker, Davor Jurkovic, Arri Coomarasamy, Natalie Nunes, Tom Holland, Fiona Clarke, Ann M. Doust, Jane P. Daniels
Summary: This study evaluated whether oral gefitinib in combination with methotrexate is more effective than methotrexate alone in the treatment of tubal ectopic pregnancy. The results showed that oral gefitinib does not offer clinical benefit over methotrexate and increases minor adverse reactions.
Article
Rheumatology
Renaud Felten, Valerie Devauchelle-Pensec, Raphaele Seror, Pierre Duffau, David Saadoun, Eric Hachulla, Hatron Pierre Yves, Carine Salliot, Aleth Perdriger, Jacques Morel, Arsene Mekinian, Olivier Vittecoq, Jean-Marie Berthelot, Emanuelle Dernis, Veronique Le Guern, Philippe Dieude, Claire Larroche, Christophe Richez, Thierry Martin, Charles Zarnitsky, Gilles Blaison, Pierre Kieffer, Francois Maurier, Azeddine Dellal, Stephanie Rist, Emmanuel Andres, Anne Contis, Emmanuel Chatelus, Christelle Sordet, Jean Sibilia, Cecile Arnold, Mira Y. Tawk, Ouafaa Aberkane, Lise Holterbach, Patrice Cacoub, Alain Saraux, Xavier Mariette, Nicolas Meyer, Jacques-Eric Gottenberg
Summary: This study aimed to demonstrate the efficacy of targeting interleukin 6 receptor in patients with primary Sjogren's syndrome-related systemic complications. However, the results showed that over 24 weeks of treatment, tocilizumab did not improve systemic involvement and symptoms in patients with primary Sjogren's syndrome.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Clinical Neurology
Michael J. R. Desborough, Rustam Al-Shahi Salman, Simon J. Stanworth, Diane Havard, Lisa J. Woodhouse, Jennifer Craig, Kailash Krishnan, Paul M. Brennan, Robert A. Dineen, Tim J. Coats, Trish Hepburn, Philip M. Bath, Nikola Sprigg, DASH Trial Investigators
Summary: This study assessed the feasibility of randomizing patients with spontaneous intracerebral hemorrhage who are taking antiplatelet drugs to receive desmopressin or placebo. The results showed that randomizing patients to receive desmopressin or placebo was feasible. This finding supports the need for a definitive trial to determine if desmopressin improves outcomes in patients with intracerebral hemorrhage on antiplatelet drug therapy.
Article
Oncology
Dean A. Fennell, Sean Ewings, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Kayleigh Hill, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Aarti Gaba, Liz Darlison, Peter Wells-Jordan, Cathy Richards, Charlotte Poile, Jason F. Lester, Gareth Griffiths
Summary: The study evaluated the efficacy and safety of nivolumab in patients with pleural or peritoneal malignant mesothelioma who had progressed following platinum-based chemotherapy. Nivolumab showed improved progression-free survival and overall survival compared to placebo in these patients, with manageable treatment-related adverse events. The results suggest that nivolumab might be a beneficial treatment for patients with malignant mesothelioma who have progressed on first-line therapy.
Article
Clinical Neurology
Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C. Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C. Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y. Hsu, Gagan Sharma, Peter J. Mitchell, Bernard Yan, Mark W. Parsons, Christopher Levi, Geoffrey A. Donnan, Stephen M. Davis
Summary: The STOP-MSU trial aims to investigate the effectiveness of tranexamic acid in reducing hematoma growth in patients with intracerebral hemorrhage. The study will be conducted in mobile stroke units and emergency departments, with an expected sample size of 180 patients.
STROKE AND VASCULAR NEUROLOGY
(2022)
Article
Clinical Neurology
Pedro M. Machado, Michael P. McDermott, Thomas Blaettler, Claus Sundgreen, Anthony A. Amato, Emma Ciafaloni, Miriam Freimer, Summer B. Gibson, Sarah M. Jones, Todd D. Levine, Thomas E. Lloyd, Tahseen Mozaffar, Aziz Shaibani, Matthew Wicklund, Anders Rosholm, Tim Dehli Carstensen, Karen Bonefeld, Anders Norkaer Jorgensen, Karina Phonekeo, Andrew J. Heim, Laura Herbelin, Richard J. Barohn, Michael G. Hanna, Mazen M. Dimachkie
Summary: Arimoclomol did not show efficacy in individuals with inclusion body myositis compared to placebo, but it had an acceptable safety profile. This study provides valuable data on disease progression for future clinical trial designs in inclusion body myositis.
Article
Gastroenterology & Hepatology
Evan S. Dellon, Kathryn A. Peterson, Benjamin L. Mitlyng, Alina Iuga, Christine E. Bookhout, Lindsay M. Cortright, Kacie B. Walker, Timothy S. Gee, Sarah J. McGee, Brenderia A. Cameron, Joseph A. Galanko, John T. Woosley, Swathi Eluri, Susan E. Moist, Ikuo Hirano
Summary: This study aimed to determine the efficacy of mepolizumab in improving dysphagia symptoms and reducing esophageal eosinophil counts in EoE. The results showed that mepolizumab significantly decreased symptoms and eosinophil counts within 3 months, but longer treatment did not yield additional improvement.
Article
Respiratory System
Dave Singh, Jutta Beier, Carol Astbury, Maria G. Belvisi, Carla A. Da Silva, Alexandra Jauhiainen, Eulalia Jimenez, Alejhandra Lei, Sofia Necander, Jaclyn A. Smith, Ulrika Wahlby Hamren, Wenjing Xin, Ioannis Psallidas
Summary: Navafenterol, a new bronchodilator for COPD treatment, was found to improve lung function and alleviate COPD symptoms similar to an established bronchodilator, with good safety profile.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Clinical Neurology
Laure Peter-Derex, Frederic Philippeau, Pierre Garnier, Nathalie Andre-Obadia, Sebastien Boulogne, Helene Catenoix, Philippe Convers, Laure Mazzola, Michel Gouttard, Maud Esteban, Julia Fontaine, Laura Mechtouff, Elodie Ong, Tae-Hee Cho, Norbert Nighoghossian, Nathalie Perreton, Anne Termoz, Julie Haesebaert, Anne-Marie Schott, Muriel Rabilloud, Christine Pivot, Carole Dhelens, Andrea Filip, Yves Berthezene, Sylvain Rheims, Florent Boutitie, Laurent Derex
Summary: This study found that prophylactic levetiracetam may reduce the risk of acute seizures in patients with intracerebral haemorrhage. However, larger studies are needed to determine whether seizure prophylaxis improves functional outcomes in these patients.
Article
Clinical Neurology
Lydia Foster, Laura Robinson, Sharon D. Yeatts, Robin A. Conwit, Amjad Shehadah, Vasileios Lioutas, Magdy Selim
Summary: This study evaluated the trajectory of modified Rankin Scale (mRS) among patients with intracerebral hemorrhage (ICH) over a 6-month period and found that treatment with deferoxamine had a favorable effect on the trajectory. Future ICH trials should assess outcomes for a minimum of 6 months after 90 days.
Article
Medicine, General & Internal
Arvind Dasari, Sara Lonardi, Rocio Garcia-Carbonero, Elena Elez, Takayuki Yoshino, Alberto Sobrero, James Yao, Pilar Garcia-Alfonso, Judit Kocsis, Antonio Cubillo Gracian, Andrea Sartore-Bianchi, Taroh Satoh, Violaine Randrian, Jiri Tomasek, Geoff Chong, Andrew Scott Paulson, Toshiki Masuishi, Jeremy Jones, Tibor Csoszi, Chiara Cremolini, Francois Ghiringhelli, Ardaman Shergill, Howard S. Hochster, John Krauss, Ali Bassam, Michel Ducreux, Anneli Elme, Laurence Faugeras, Stefan Kasper, Eric Van Cutsem, Dirk Arnold, Shivani Nanda, Zhao Yang, William R. Schelman, Marek Kania, Josep Tabernero, Cathy Eng
Summary: This study evaluated the efficacy and safety of fruquintinib, a highly selective and potent oral inhibitor of VEGFRs 1, 2, and 3, in patients with advanced, chemotherapy-refractory colorectal cancer. The results showed that fruquintinib significantly prolonged overall survival compared to placebo in patients with refractory metastatic colorectal cancer, with clinical significance. Therefore, fruquintinib could become a global treatment option for patients with refractory metastatic colorectal cancer.
Article
Medicine, General & Internal
Martina Schneider, Marivic Narciso-Abraham, Sandra Hadl, Robert Mcmahon, Sebastian Toepfer, Ulrike Fuchs, Romana Hochreiter, Annegret Bitzer, Karin Kosulin, Julian Larcher-Senn, Robert Mader, Katrin Dubischar, Oliver Zoihsl, Juan-Carlos Jaramillo, Susanne Eder-Lingelbach, Vera Buerger, Nina Wressnigg
Summary: This study investigated the safety and immunogenicity of the live-attenuated vaccine candidate VLA1553 for chikungunya virus. The results showed that a single dose of VLA1553 induced a strong immune response and generated seroprotective antibody levels in almost all vaccinated participants. The vaccine was well tolerated and had a favorable safety profile.
Article
Clinical Neurology
Jessalyn K. Holodinsky, Patrice Lindsay, Amy Y. X. Yu, Aravind Ganesh, Raed A. Joundi, Michael D. Hill
Summary: This study used administrative data to estimate the number of stroke events resulting in hospital or emergency department presentation across Canada in the 2017-18 fiscal year. The findings indicate that a stroke event resulting in hospital or emergency department presentation occurs every 5 minutes in Canada.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Critical Care Medicine
Victoria Fleming, Susanne Muehlschlegel
CRITICAL CARE CLINICS
(2023)
Article
Critical Care Medicine
Chiara Robba, Francesca Graziano, Angelo Guglielmi, Paola Rebora, Stefania Galimberti, Fabio Taccone, Giuseppe Citerio, SYNAPSE-ICU Investigators
Summary: This study aims to describe the therapeutical approaches used in managing intracranial hypertension in acute brain injured patients and their association with six months mortality and neurological outcome. The results showed that therapies to control high ICP were frequently used during the first week of ICU admission, especially mild-moderate treatments. In some selected patients, the use of aggressive strategies may be beneficial for the six months mortality but not for neurological outcome.
INTENSIVE CARE MEDICINE
(2023)
Article
Clinical Neurology
K. Zhu, F. Bala, J. Zhang, F. Benali, P. Cimflova, B. J. Kim, R. McDonough, N. Singh, M. D. Hill, M. Goyal, A. Demchuk, B. K. Menon, W. Qiu
Summary: This article aims to develop an automated approach to quantify thrombus on NCCT and CTA in patients with stroke. The deep learning model obtained reliable results in both internal and external datasets.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Ubong Udoh, Brian Dewar, Stuart Nicholls, Mark Fedyk, Robert Fahed, Jeff Perry, Michael D. Hill, Bijoy Menon, Richard H. Swartz, Alexandre Y. Poppe, Sophia Gocan, Jamie Brehaut, Katie Dainty, Victoria Shepherd, Dar Dowlatshahi, Michel Shamy
Summary: Advance consent is a potential solution to the challenge of obtaining informed consent for acute stroke trials. Canadian stroke clinic physicians expressed comfort and willingness in obtaining advance consent, with minimal disruption to clinic workflow. These findings support further investigation of advance consent for acute stroke trials.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Ayoola Ademola, Lehana Thabane, Joel Adekanye, Ayooluwanimi Okikiolu, Samuel Babatunde, Mohammed A. Almekhlafi, Bijoy K. Menon, Michael D. Hill, Kevin A. Hildebrand, Tolulope T. Sajobi
Summary: This study evaluated the credibility of subgroup analyses in stroke trials and found that the quality of subgroup analysis reporting remains poor, indicating a need for improved training and guidance.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Letter
Clinical Neurology
Nishita Singh, Petra Cimflova, Johanna Maria Ospel, Nima Kashani, Martha Marko, Arnuv D. Mayank, Michael Hill
Article
Health Care Sciences & Services
Harry Mee, Ana M. Castano-Leon, Ivan Timofeev, Amos Adeleye, Indira Devi Bhagavatula, Niklas Marklund, Susanne Muehlschlegel, Katie Bond, Clare Clement, Kirsty Grieve, Nicola Owen, Gemma Whiting, Carole Turner, Andres Mariano Rubiano Escobar, Dhaval Shukla, Maria Paul, Judith Allanson, Valerie Pomeroy, Edoardo Viaroli, Elizabeth Warburton, Adam Wells, Gregory Hawryluk, Adel Helmy, Fahim Anwar, Stephen Honeybul, Peter Hutchinson, Angelos Kolias
Summary: The study aims to establish a standardized core outcome set (COS) for cranioplasty in traumatic brain injury (TBI) and stroke patients. Data will be collected through systematic review and qualitative study, followed by Delphi survey and consensus meetings for COS development. The study is expected to be completed by the end of 2022 or the beginning of 2023.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Clinical Neurology
Rena Seeger, Ubong Udoh, Brian Dewar, Stuart Nicholls, Mark Fedyk, Robert Fahed, Jeff Perry, Michael D. Hill, Bijoy Menon, Richard H. Swartz, Alexandre Y. Poppe, Sophia Gocan, Jamie Brehaut, Katie Dainty, Victoria Shepherd, Dar Dowlatshahi, Michel Shamy
Summary: This survey explores the acceptability of advance consent among Canadian Research Ethics Board (REB) chairs who review acute stroke trials. The majority of respondents expressed comfort approving studies that adopt advance consent, but no clear preference for advance consent over deferral of consent emerged. Concerns were raised about broad rather than trial-specific advance consent. These findings shed light on the acceptability of advance consent to Canadian ethics regulators.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Miranda Wan, Patrice Lindsay, Amy Y. X. Yu, Michael D. Hill, Jessalyn K. Holodinsky
Summary: We provide an updated estimate of adult stroke event rates by age group, sex, and stroke type using Canadian administrative data. Overall, our findings show that there are similar stroke event rates between women and men, with slight differences in stroke event rate at various ages by sex and stroke type. These emerging patterns warrant attention in future studies. Our findings emphasize the importance of continuous surveillance to monitor the epidemiology of stroke in Canada.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Shazeb Meraj, Shravan Sivakumar, Susanne Muehlschlegel
Summary: This review examines the role of shared decision-making in neurocritical care units and discusses interventions that can improve the involvement of patients' surrogates. Findings suggest that surrogates of critically ill patients wish to be more involved in decision-making, and several interventions including information leaflets, family support interventions, and decision aids have been developed and tested in ICUs. Future research will evaluate the effectiveness and implementation of these interventions in neuroICUs.
CURRENT TREATMENT OPTIONS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Alexander D. Rebchuk, Michael D. Hill, Mayank Goyal, Andrew Demchuk, Shelagh B. Coutts, Negar Asdaghi, Dar Dowlatshahi, Jessalyn K. Holodinsky, Enrico Fainardi, Jai Shankar, Mohamed Najm, Marta Rubiera, Alexander Khaw, Wu Qiu, Bijoy K. Menon, Thalia S. Field
Summary: Women, especially postmenopausal women, have worse outcomes after acute ischemic stroke. One possible reason for this is the decrease in the vasculoprotective effects of estrogen in older women. This study investigated the effects of sex and age on neuroradiological predictors of recanalization in acute ischemic stroke patients. The results showed that there was no association between sex and radiological predictors of recanalization.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neuroimaging
Nathaniel Rex, Johanna M. Ospel, Scott B. Brown, Rosalie McDonough, Nima Kashani, Michael D. Hill, Diederik W. J. Dippel, Bruce Campbell, Keith W. Muir, Andrew M. Demchuk, Serge Bracard, Francis Guillemin, Tudor G. Jovin, Peter J. Mitchell, Phil White, Charles B. L. M. Majoie, Jeffrey L. Saver, Mayank Goyal
Summary: This study compared the functional outcomes of patients with acute ischemic stroke (AIS) with large vessel occlusion (LVO) who underwent endovascular treatment (EVT) with poor reperfusion, with those who received best medical management only. The results showed that patients with poor reperfusion after EVT had worse functional outcomes compared to those who only received medical management.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Correction
Critical Care Medicine
Katharina M. Busl, Herbert Fried, Susanne Muehlschlegel, Katja E. Wartenberg, Venkatakrishna Rajajee, Sheila A. Alexander, Claire J. Creutzfeldt, Gabriel V. Fontaine, Sara E. Hocker, David Y. Hwang, Keri S. Kim, Dominik Madzar, Dea Mahanes, Shraddha Mainali, Juergen Meixensberger, Oliver W. Sakowitz, Panayiotis N. Varelas, Thomas Westermaier, Christian Weimar
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Faysal Benali, Joachim Fladt, Tanaporn Jaroenngarmsamer, Fouzi Bala, Nishita Singh, Johanna Maria Ospel, Michael Tymianski, Michael D. Hill, Mayank Goyal, Aravind Ganesh
Summary: Brain atrophy, as assessed on acute noncontrast computed tomography imaging, was found to be associated with less favorable stroke recovery and worse 90-day functional outcomes after endovascular thrombectomy (EVT). This information may help physicians manage recovery expectations and plan post-EVT care for patients and their families.