4.6 Review

Biomarker detection technologies and future directions

期刊

ANALYST
卷 141, 期 3, 页码 740-755

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5an01790d

关键词

-

资金

  1. Technological Innovation R&D Program - Small and Medium Business Administration (SMBA), Korea [S2130946]
  2. Hallym University Research Fund [HRF-201504-018]
  3. Korea Evaluation Institute of Industrial Technology (KEIT) [S2130946] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Biomarkers play a vital role in disease detection and treatment follow-up. It is important to note that diseases in the early stage are typically treated with the greatest probability of success. However, due to various technical difficulties in current technologies for the detection of biomarkers, the potential of biomarkers is not explored completely. Therefore, the developments of technologies, which can enable the accurate detection of prostate cancer at an early stage with simple, experimental protocols are highly inevitable. This critical review evaluates the current methods and technologies used in the detection of biomarkers. The aim of this article is to provide a comprehensive review covering the advantages and disadvantages of the biomarker detection methods. Future directions for the development of technologies to achieve highly selective and sensitive detection of biomarkers for point-of-care applications are also commented on.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Pharmacology & Pharmacy

GSK-3 inhibitors: A New Class of Drugs for Alzheimer's Disease Treatment

Dilipkumar Pal, Souvik Mukherjee, In-Ho Song, Satish B. Nimse

Summary: Alzheimer's disease is a common form of dementia caused by cognitive function impairment, with research suggesting the involvement of GSK-3 in the hyper-phosphorylation of tau proteins, making it a potential target for AD treatment. Inhibitors of GSK-3 have received significant attention for their potential therapeutic applications in AD and other diseases.

CURRENT DRUG TARGETS (2021)

Review Pharmacology & Pharmacy

Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders

Supriyo Saha, Dilipkumar Pal, Satish B. Nimse

Summary: The study examined the development of synthetic GSK-3 inhibitors for the prevention and treatment of neurological disorders, such as Alzheimer's disease and bipolar disorders. The synthesized molecules have shown remarkable effects in combating Alzheimer's, Parkinson's depression, psychosis, and other forms of neurological disorders.

CURRENT DRUG TARGETS (2021)

Review Chemistry, Medicinal

Indazole Derivatives Effective against Gastrointestinal Diseases

Supriyo Saha, Dilipkumar Pal, Satish Balasaheb Nimse

Summary: This manuscript focuses on the importance of indazole derivatives in the treatment of various gastrointestinal diseases. Different indazole derivatives play a critical role in the treatment of different diseases such as IBS, diarrhea, metabolic syndrome, and gastrointestinal cancers. By analyzing the receptors associated with gastrointestinal disorders, it was found that indazole derivatives can effectively interact with the receptors.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2022)

Article Chemistry, Medicinal

Synthesis and evaluation of 2-aryl-1H-benzo[d]imidazole derivatives as potential microtubule targeting agents

Jung-Seop Lee, In-ho Song, Shrikant Dashrath Warkad, Gyu Seong Yeom, Pramod B. Shinde, Keum-soo Song, Satish Balasaheb Nimse

Summary: In this study, a series of 2,5-substituted-1H-benzo[d]imidazole derivatives were synthesized and it was demonstrated that compounds B15, B16, B19, and B20 exhibit excellent anticancer activity.

DRUG DEVELOPMENT RESEARCH (2022)

Article Chemistry, Analytical

Detection and Quantification of Tp53 and p53-Anti-p53 Autoantibody Immune Complex: Promising Biomarkers in Early Stage Lung Cancer Diagnosis

Keum-Soo Song, Satish Balasaheb Nimse, Shrikant Dashrath Warkad, Jung-Hoon Kim, Hey-Jin Kim, Taisun Kim

Summary: Lung cancer is a leading cause of death globally. Low-dose computed tomography (LDCT) reduces lung cancer mortality by 20% compared to standard chest X-rays among current or heavy smokers, but has a high false-positive rate. This study presents a method based on biomarker detection to complement LDCT for detecting various stages of lung cancer.

BIOSENSORS-BASEL (2022)

Article Biochemistry & Molecular Biology

Indazole-based microtubule-targeting agents as potential candidates for anticancer drugs discovery

Dilipkumar Pal, In-ho Song, Shrikant Dashrath Warkad, Keum-soo Song, Gyu Seong Yeom, Supriyo Saha, Pramod B. Shinde, Satish Balasaheb Nimse

Summary: This review presents the research advances on compounds containing indazole scaffolds as microtubule targeting agents based on articles published in the last two decades. Several compounds have shown potent microtubule inhibition and anticancer activity, with some of them having the lowest IC50 values observed in cell line studies.

BIOORGANIC CHEMISTRY (2022)

Article Biotechnology & Applied Microbiology

Combination Therapy of Ledipasvir and Itraconazole in the Treatment of COVID-19 Patients Coinfected with Black Fungus: An In Silico Statement

Supriyo Saha, Gyu Seong Yeom, Satish Balasaheb Nimse, Dilipkumar Pal

Summary: The manuscript focuses on providing clues to enhance the innate immunity of coronavirus patients and protect them from new mutant strains and black fungus infections. Through molecular docking studies, potential therapeutic candidates for COVID-19 and drugs for treating black fungus infections were identified. The combined therapy of ledipasvir and itraconazole could be a better alternative for treating COVID-19 patients coinfected with black fungus.

BIOMED RESEARCH INTERNATIONAL (2022)

Article Chemistry, Analytical

Elimination Reaction-Based Benzimidazole Probe for Cysteine Detection and Its Application in Serum Sample Analysis

In-ho Song, Gyu Seong Yeom, Anil Kuwar, Satish Balasaheb Nimse

Summary: In this study, a benzimidazole-based compound and its derivative probe were synthesized for the highly selective detection and quantification of cysteine in human serum. The derivative probe showed high selectivity and sensitivity for cysteine and achieved lower detection limits compared to reported methods in serum samples.

BIOSENSORS-BASEL (2022)

Article Biochemistry & Molecular Biology

Exploration of Molecular Structure, DFT Calculations, and Antioxidant Activity of a Hydrazone Derivative

Kundan Tayade, Gyu-Seong Yeom, Suban K. Sahoo, Horst Puschmann, Satish Balasaheb Nimse, Anil Kuwar

Summary: This study synthesized Schiff base compound 2 and determined its crystal structure and molecular structure. The antioxidant activity of this compound was confirmed through calculations and experiments. The compound exhibited excellent antioxidant activity and low cytotoxicity.

ANTIOXIDANTS (2022)

Article Chemistry, Analytical

Highly sensitive and rapid detection of hypochlorous acid in aqueous media and its bioimaging in live cells and zebrafish using an ESIPT-driven mycophenolic acid-based fluorescent probe

Prasad M. Sonawane, Neha Jain, Arkaprava Roychaudhury, Su Jeong Park, Vikas K. Bhosale, Mahesh B. Halle, Cheol-Hee Kim, Satish Balasaheb Nimse, David G. Churchill

Summary: This study introduces the synthesis and application of a highly sensitive fluorescence turn-on probe, Myco-OCl, for the specific and rapid detection of HOCl. The probe shows exceptional performance and has been successfully applied for live cell imaging and detection of HOCl in a zebrafish model.

ANALYST (2023)

Article Chemistry, Analytical

Highly sensitive and rapid detection of hypochlorous acid in aqueous media and its bioimaging in live cells and zebrafish using an ESIPT-driven mycophenolic acid-based fluorescent probe

Prasad M. Sonawane, Neha Jain, Arkaprava Roychaudhury, Su Jeong Park, Vikas K. Bhosale, Mahesh B. Halle, Cheol-Hee Kim, Satish Balasaheb Nimse, David G. Churchill

Summary: This study introduces a highly sensitive fluorescence turn-on probe, Myco-OCl, for detecting HOCl with exceptional specificity and rapid response. The probe has great potential for detecting HOCl in diverse physiological systems.

ANALYST (2023)

Article Chemistry, Medicinal

ID-Checker Technology for the Highly Selective Macroscale Delivery of Anticancer Agents to the Cancer Cells

Keum-soo Song, Satish Balasaheb Nimse, Junghoon Kim, Shrikant Dashrath Warkad, Taisun Kim

Summary: The developed ID-Checker enables highly specific delivery of anticancer agents to cancer cells through GLUT channels, resulting in cancer cell death within a short period of time without causing damage to normal cells.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Fluorescence 'turn-on' probe for nanomolar Zn(II) detection in living cells and environmental samples

Manohar Patil, Su Jeong Park, Gyu Seong Yeom, Ratnamala Bendre, Anil Kuwar, Satish Balasaheb Nimse

Summary: A Schiff base ligand FHE was synthesized and showed specific complex formation with Zn2+ ions, resulting in enhanced fluorescence. FHE demonstrated high sensitivity for detecting Zn2+ ions in living cells and environmental samples.

NEW JOURNAL OF CHEMISTRY (2022)

Correction Materials Science, Multidisciplinary

The detection of Al3+ and Cu2+ ions using isonicotinohydrazide-based chemosensors and their application to live-cell imaging (Aug, 10.1039/d1ma00564b, 2021)

In-ho Song, Pritam Torawane, Jung-Seop Lee, Shrikant Dashrath Warkad, Amulrao Borase, Suban K. Sahoo, Satish Balasaheb Nimse, Anil Kuwar

Summary: The study successfully detected Al3+ and Cu2+ ions using isonicotinohydrazide-based chemosensors and applied them to live-cell imaging.

MATERIALS ADVANCES (2021)

Article Materials Science, Multidisciplinary

The detection of Al3+ and Cu2+ ions using isonicotinohydrazide-based chemosensors and their application to live-cell imaging

In-ho Song, Pritam Torawane, Jung-Seop Lee, Shrikant Dashrath Warkad, Amulrao Borase, Suban K. Sahoo, Satish Balasaheb Nimse, Anil Kuwar

Summary: The newly synthesized Schiff base receptor 3 exhibits excellent selectivity and sensitivity towards Cu2+ and Al3+ ions through UV-vis absorption and fluorescence spectroscopy, respectively. It shows detectable color changes and significant fluorescent enhancement in the presence of these ions, with a much lower limit of detection for Al3+ ions.

MATERIALS ADVANCES (2021)

暂无数据