Molecular Biomarkers in Idiopathic Pulmonary Fibrosis: State of the Art and Future Directions

Potential clinical utility of MUC5B und TOLLIP single nucleotide polymorphisms (SNPs) in the management of patients with IPF

(2021) Francesco Bonella et al.   Orphanet Journal of Rare Diseases

Prognostic role of Krebs von den Lungen-6 (KL-6) measurement in idiopathic pulmonary fibrosis: a systematic review and meta-analysis

(2021) Elena Aloisio et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis

(2020) Takumi Yoshikawa et al.   BMC Pulmonary Medicine

Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

(2020) Xianhua Gui et al.   Biomed Research International

Osteopontin enhances the migration of lung fibroblasts via upregulation of interleukin-6 through the ERK pathway

(2020) Yu Fujisawa et al.   BIOLOGICAL CHEMISTRY

Circulating Plasma Biomarkers of Survival in Anti-fibrotic Treated Patients with Idiopathic Pulmonary Fibrosis

(2020) Ayodeji Adegunsoye et al.   CHEST

Impact of genetic factors on fibrosing interstitial lung diseases Incidence and clinical presentation in adults

(2020) Raphael Borie et al.   PRESSE MEDICALE

Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort

(2020) Jamie L. Todd et al.   BMC Pulmonary Medicine

Identification and functional characterization of a novel surfactant protein A2 mutation (p.N207Y) in a Chinese family with idiopathic pulmonary fibrosis

(2020) Lv Liu et al.   Molecular Genetics & Genomic Medicine

Calgranulin B and KL-6 in Bronchoalveolar Lavage of Patients with IPF and NSIP

(2019) David Bennett et al.   INFLAMMATION

Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by Toll-like receptor 4 activation

(2019) Kelly M Hanson et al.   TOXICOLOGICAL SCIENCES

A retrospective study of the tolerability of nintedanib for severe idiopathic pulmonary fibrosis in the real world

(2019) Masayuki Nakamura et al.   Annals of Translational Medicine

Clinical Research on Prognostic Evaluation of Subjects With IPF by Peripheral Blood Biomarkers, Quantitative Imaging Characteristics and Pulmonary Function Parameters

(2019) Lu Guo et al.   ARCHIVOS DE BRONCONEUMOLOGIA

The relationship between MUC5B promoter, TERT polymorphisms and telomere lengths with radiographic extent and survival in a Chinese IPF cohort

(2019) Hui Wang et al.   Scientific Reports

Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis

(2019) Sushweta Mahalanobish et al.   PHARMACOLOGICAL RESEARCH

The serum KL-6 levels in untreated idiopathic pulmonary fibrosis can naturally decline in association with disease progression

(2018) Hiroshi Ishii et al.   Clinical Respiratory Journal

C-proSP-B: A Possible Biomarker for Pulmonary Diseases?

(2018) Nicolas Kahn et al.   RESPIRATION

Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2018) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sequential changes of serum KL-6 predict the progression of interstitial lung disease

(2018) Ying Jiang et al.   Journal of Thoracic Disease

Toll-like receptors in the pathogenesis of pulmonary fibrosis

(2017) Theodoros Karampitsakos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prevalence and incidence of interstitial lung diseases in a multi-ethnic county of Greater Paris

(2017) Boris Duchemann et al.   EUROPEAN RESPIRATORY JOURNAL

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis

(2017) Kai Wang et al.   MEDICINE

Idiopathic pulmonary fibrosis: Clinical behavior and aging associated comorbidities

(2017) Ivette Buendía-Roldán et al.   RESPIRATORY MEDICINE

Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone

(2017) Kimiyuki Ikeda et al.   RESPIRATORY MEDICINE

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study

(2017) Toby M Maher et al.   Lancet Respiratory Medicine

Plasma Surfactant Protein-D, Matrix Metalloproteinase-7, and Osteopontin Index Distinguishes Idiopathic Pulmonary Fibrosis from Other Idiopathic Interstitial Pneumonias

(2016) Eric S. White et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis

(2016) Kosuke Hamai et al.   DISEASE MARKERS

GermlineSFTPA1mutation in familial idiopathic interstitial pneumonia and lung cancer

(2016) Nadia Nathan et al.   HUMAN MOLECULAR GENETICS

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

(2016) Jiurong Liang et al.   NATURE MEDICINE

SFTPA2Mutations in Familial and Sporadic Idiopathic Interstitial Pneumonia

(2015) Coline H. M. van Moorsel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Idiopathic pulmonary fibrosis in BRIC countries: the cases of Brazil, Russia, India, and China

(2015) Luca Richeldi et al.   BMC Medicine

The MUC5B Promoter Polymorphism Is Associated With Idiopathic Pulmonary Fibrosis in a Mexican Cohort but Is Rare Among Asian Ancestries

(2015) Anna L. Peljto et al.   CHEST

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review

(2015) John Hutchinson et al.   EUROPEAN RESPIRATORY JOURNAL

Quantitative Proteomics of Bronchoalveolar Lavage Fluid in Idiopathic Pulmonary Fibrosis

(2015) Matthew W. Foster et al.   JOURNAL OF PROTEOME RESEARCH

Association Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis

(2015) Qing-Qing Zhu et al.   MEDICINE

Change in serum marker of oxidative stress in the progression of idiopathic pulmonary fibrosis

(2015) Yasuo Matsuzawa et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias

(2015) António Morais et al.   RESPIRATORY MEDICINE

MUC5Bpromoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis

(2015) Yasushi Horimasu et al.   RESPIROLOGY

Association between telomere length and survival in patients with idiopathic pulmonary fibrosis

(2015) Jinghong Dai et al.   RESPIROLOGY

Molecular biomarkers in idiopathic pulmonary fibrosis

(2014) Brett Ley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting defective Toll-like receptor-3 function and idiopathic pulmonary fibrosis

(2014) David N O’Dwyer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Idiopathic Pulmonary Fibrosis: From Epithelial Injury to Biomarkers - Insights from the Bench Side

(2014) Keren Borensztajn et al.   RESPIRATION

Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis

(2014) Shinichiro Ohshimo et al.   RESPIRATORY MEDICINE

Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: an observational cohort study with independent validation

(2014) Bridget D Stuart et al.   Lancet Respiratory Medicine

The Toll-like Receptor 3 L412F Polymorphism and Disease Progression in Idiopathic Pulmonary Fibrosis

(2013) David N. O’Dwyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Blood Biomarkers MMP-7 and SP-A

(2013) Jin Woo Song et al.   CHEST

Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis

(2013) Anna L. Peljto et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MUC5B Promoter Polymorphism and Interstitial Lung Abnormalities

(2013) Gary M. Hunninghake et al.   NEW ENGLAND JOURNAL OF MEDICINE

The MUC5B Variant Is Associated with Idiopathic Pulmonary Fibrosis but Not with Systemic Sclerosis Interstitial Lung Disease in the European Caucasian Population

(2013) Raphael Borie et al.   PLoS One

Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis

(2013) Carmel J Stock et al.   THORAX

Association between MUC5B and TERT polymorphisms and different interstitial lung disease phenotypes

(2013) Rongrong Wei et al.   Translational Research

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study

(2013) Imre Noth et al.   Lancet Respiratory Medicine

Idiopathic Pulmonary Fibrosis: Phenotypes and Comorbidities

(2012) Charlene D. Fell   CLINICS IN CHEST MEDICINE

The big clinical trials in idiopathic pulmonary fibrosis

(2012) Fabrizio Luppi et al.   CURRENT OPINION IN PULMONARY MEDICINE

Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis

(2012) Seung-Ick Cha et al.   RESPIRATORY RESEARCH

Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals

(2012) Line Rode et al.   THORAX

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Variant in the Promoter ofMUC5Band Idiopathic Pulmonary Fibrosis

(2011) Yingze Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

A CommonMUC5BPromoter Polymorphism and Pulmonary Fibrosis

(2011) Max A. Seibold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis

(2010) Harold R. Collard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Surfactant Protein C Mutations Are the Basis of a Significant Portion of Adult Familial Pulmonary Fibrosis in a Dutch Cohort

(2010) Coline H. M. van Moorsel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Clinical Course and Prediction of Survival in Idiopathic Pulmonary Fibrosis

(2010) Brett Ley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease

(2010) Jeffrey A. Whitsett et al.   Annual Review of Medicine

Characteristics of disorders associated with genetic mutations of surfactant protein C

(2010) G. Thouvenin et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Surfactant Protein A2 Mutations Associated with Pulmonary Fibrosis Lead to Protein Instability and Endoplasmic Reticulum Stress

(2010) Meenakshi Maitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Expression Profiles of Acute Exacerbations of Idiopathic Pulmonary Fibrosis

(2009) Kazuhisa Konishi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Serum Surfactant Protein-A Is a Strong Predictor of Early Mortality in Idiopathic Pulmonary Fibrosis

(2009) Brent W. Kinder et al.   CHEST

Telomere Diseases

(2009) Rodrigo T. Calado et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Phenotypes Distinguish Patients with Relatively Stable from Progressive Idiopathic Pulmonary Fibrosis (IPF)

(2009) Kathy Boon et al.   PLoS One

Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer

(2008) Yongyu Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

(2008) J. K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA