Skin barrier in atopic dermatitis: beyond filaggrin

Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum

(2015) Mariko Yokouchi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Toll-Like Receptor 3 Activation Is Required for Normal Skin Barrier Repair Following UV Damage

(2015) Andrew W. Borkowski et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hypoxia-Inducible Factors Regulate Filaggrin Expression and Epidermal Barrier Function

(2015) Waihay J. Wong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The role of innate immune signaling in the pathogenesis of atopic dermatitis and consequences for treatments

(2015) Yuliya Skabytska et al.   Seminars in Immunopathology

Lowered Humidity Produces Human Epidermal Equivalents with Enhanced Barrier Properties

(2015) Richard Sun et al.   TISSUE ENGINEERING PART C-METHODS

Impaired NLRP3 inflammasome expression and function in atopic dermatitis due to Th2 milieu

(2014) M. Niebuhr et al.   ALLERGY

Update on innate lymphoid cells in atopic and non-atopic inflammation in the airways and skin

(2014) J. Mjösberg et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Skin Barrier Defects in Atopic Dermatitis

(2014) Rachana Agrawal et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis

(2014) Jacob P. Thyssen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis

(2014) Kazue Yoshida et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Profile of skin barrier proteins (filaggrin, claudins 1 and 4) and Th1/Th2/Th17 cytokines in adults with atopic dermatitis

(2014) D.I.S. Batista et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Circulating Conventional and Plasmacytoid Dendritic Cell Subsets Display Distinct Kinetics duringIn VivoRepeated Allergen Skin Challenges in Atopic Subjects

(2014) Stelios Vittorakis et al.   Biomed Research International

Cell death by cornification

(2013) Leopold Eckhart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Natural killer cells in patients with allergic diseases

(2013) Günnur Deniz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The cutaneous innate immune response in patients with atopic dermatitis

(2013) I-Hsin Kuo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin Deficiency Leads to Impaired Lipid Profile and Altered Acidification Pathways in a 3D Skin Construct

(2013) Kateřina Vávrová et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Comparative analysis of circulating dendritic cell subsets in patients with atopic diseases and sarcoidosis

(2013) Yumeko Hayashi et al.   RESPIRATORY RESEARCH

Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function

(2012) Hergen Spits et al.   Annual Review of Immunology

Peripheral natural killer cells exhibit qualitative and quantitative changes in patients with psoriasis and atopic dermatitis

(2012) C. Luci et al.   BRITISH JOURNAL OF DERMATOLOGY

Abnormal epidermal barrier in the pathogenesis of atopic dermatitis

(2012) Ronni Wolf et al.   CLINICS IN DERMATOLOGY

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

(2012) H. H. Kong et al.   GENOME RESEARCH

Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

(2012) Sanja Kezic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activation of Epidermal Toll-Like Receptor 2 Enhances Tight Junction Function: Implications for Atopic Dermatitis and Skin Barrier Repair

(2012) I-Hsin Kuo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

(2011) S. Kezic et al.   ALLERGY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Tight junction proteins and the epidermis

(2011) Catherine A. O’Neill et al.   EXPERIMENTAL DERMATOLOGY

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

(2011) Mark Boguniewicz et al.   IMMUNOLOGICAL REVIEWS

Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis

(2011) Anna De Benedetto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

(2011) Sara J. Brown et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activation of TLR2 Enhances Tight Junction Barrier in Epidermal Keratinocytes

(2011) T. Yuki et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial Peptides: Old Molecules with New Ideas

(2011) Teruaki Nakatsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

One Remarkable Molecule: Filaggrin

(2011) Sara J. Brown et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Innate Immunity in Atopic Dermatitis

(2010) Andreas Wollenberg et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Vaccinia virus–specific molecular signature in atopic dermatitis skin

(2010) Dmitry N. Grigoryev et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin–activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis

(2010) Wen Hao Wu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification and functions of pattern-recognition receptors

(2010) Yutaro Kumagai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus

(2010) Helen Miajlovic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tight junction defects in patients with atopic dermatitis

(2010) Anna De Benedetto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Is the Filaggrin–Histidine–Urocanic Acid Pathway Essential for Stratum Corneum Acidification?

(2010) Joachim W. Fluhr et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic dermatitis in adults: evaluation of peripheral blood mononuclear cells proliferation response toStaphylococcus aureusenterotoxins A and B and analysis of interleukin-18 secretion

(2009) Raquel Leão Orfali et al.   EXPERIMENTAL DERMATOLOGY

Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three

(2009) Joseph A. Odhiambo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epidermal Barrier Dysfunction in Atopic Dermatitis

(2009) Michael J. Cork et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Selective Antimicrobial Action Is Provided by Phenol-Soluble Modulins Derived from Staphylococcus epidermidis, a Normal Resident of the Skin

(2009) Anna L. Cogen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

(2009) Yuping Lai et al.   NATURE MEDICINE

Skin microbiota: a source of disease or defence?

(2008) A.L. Cogen et al.   BRITISH JOURNAL OF DERMATOLOGY

Basis for the barrier abnormality in atopic dermatitis: Outside-inside-outside pathogenic mechanisms

(2008) Peter M. Elias et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Specific Filaggrin Mutations Cause Ichthyosis Vulgaris and Are Significantly Associated with Atopic Dermatitis in Japan

(2008) Toshifumi Nomura et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic Dermatitis: A Disease Caused by Innate Immune Defects?

(2008) Anna De Benedetto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Resident and “Inflammatory” Dendritic Cells in Human Skin

(2008) Lisa C. Zaba et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The prevalence of atopic triad in children with physician-confirmed atopic dermatitis

(2007) Roger Kapoor et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY