Article
Biology
Trinidad Montero-Vilchez, Carlos Cuenca-Barrales, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Jesus Tercedor-Sanchez, Antonio Martinez-Lopez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study investigated the changes in skin barrier function with age in patients with atopic dermatitis (AD). The results showed that as age increased, AD patients had higher transepidermal water loss (TEWL), lower stratum corneum hydration (SCH), and reduced elasticity compared to healthy individuals. There was a negative correlation between age and elasticity, which was stronger in AD patients than in controls. Linear regression analyses revealed that age and disease severity had a significant impact on elasticity in AD patients. These findings suggest that age plays a role in impairing skin barrier function in AD patients, particularly in terms of elasticity.
Article
Veterinary Sciences
Rosanna Marsella, Kim Ahrens, Rachel Wilkes
Summary: Skin barrier dysfunction is important in atopic dermatitis and may be related to differences in cell growth behavior rather than tight junction protein differences. Atopic keratinocytes have lower TEER than normal keratinocytes, indicating higher epithelial permeability.
VETERINARY SCIENCES
(2022)
Review
Allergy
Takeshi Yoshida, Lisa A. Beck, Anna De Benedetto
Summary: Atopic dermatitis (AD) is the most common chronic skin inflammatory disease, with a profound impact on patients' quality of life. The clinical course, age of onset, and presence of allergic and non-allergic comorbidities vary greatly in AD. Skin barrier impairment is now recognized as a critical feature of AD, which may be explained by abnormalities within the layers of the epidermis.
ALLERGOLOGY INTERNATIONAL
(2022)
Review
Immunology
Risa Tamagawa-Mineoka
Summary: The skin acts as a physical barrier and toll-like receptors (TLRs) play a role in both infectious and non-infectious inflammatory diseases. In atopic dermatitis (AD), skin barrier dysfunction allows stimuli to penetrate the skin and activate the innate immune system, leading to inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
M. N. Basu, C. G. Mortz, T. K. Jensen, T. Barington, S. Halken
Summary: The study found significantly lower levels of natural moisturizing factors (NMF) in children with atopic dermatitis compared to healthy controls, with differences related to the severity of past dermatitis. Early moisturizer use was negatively correlated with NMF levels, and there was a genetic influence of FLG gene variants on NMF levels.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Masataka Ota, Takashi Sasaki, Tamotsu Ebihara, Emiko Yokosawa, Yumi Murakami, Hiroshi Matsunaka, Yuko Chinuki, Masayuki Amagai, Eishin Morita
Summary: The study found that loss-of-function mutations of the filaggrin (FLG) gene do not affect the severity of atopic dermatitis (AD) or skin barrier function, and have little impact on the amount of FLG protein and total amino acids in the stratum corneum of lesional skin. The results suggest that the production of FLG in skin lesions is influenced by the activation of Th2-dominant inflammatory cells along with FLG abnormalities.
JOURNAL OF DERMATOLOGY
(2021)
Article
Allergy
Evgeny Berdyshev, Jihyun Kim, Byung Eui Kim, Elena Goleva, Taras Lyubchenko, Irina Bronova, Anna Sofia Bronoff, Olivia Xiao, Jiwon Kim, Sukyung Kim, Mijeong Kwon, Sungjoo Lee, Yu Jeong Seo, Kyunga Kim, Suk-Joo Choi, Soo-Young Oh, Seung Hwan Kim, So Yeon Yu, Seung Yong Hwang, Kangmo Ahn, Donald Y. M. Leung
Summary: A study found that the risk of developing atopic dermatitis in the future can be predicted by analyzing the skin surface of infants at the age of two months, and identified potential biomarkers.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Review
Biochemistry & Molecular Biology
Petra Pavel, Stefan Blunder, Verena Moosbrugger-Martinz, Peter M. Elias, Sandrine Dubrac
Summary: Atopic dermatitis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Alterations of the epidermal barrier and lipid abnormalities play crucial roles in the development and inflammation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nahoko Zeze, Makiko Kido-Nakahara, Gaku Tsuji, Eriko Maehara, Yuki Sato, Sawako Sakai, Kei Fujishima, Akiko Hashimoto-Hachiya, Masutaka Furue, Takeshi Nakahara
Summary: Atopic dermatitis is a skin disorder characterized by inflammation, barrier disruption, and intense itch. This study investigates the involvement of the extracellular signal-regulated kinase (ERK) pathway in the pathogenesis of atopic dermatitis. The results suggest that the ERK pathway plays a role in the development of atopic dermatitis and may be a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
A. M. Andersson, A. C. Ingham, S. M. Edslev, J. Solberg, L. Skov, A. Koch, K. Ghauharali-van der Vlugt, F. S. Stet, C. M. Brueggen, I. Jakasa, S. Kezic, J. P. Thyssen
Summary: The skin microbiota, cytokine, and lipid composition differ significantly between Greenlandic Inuit and Danish children with AD, with a stronger type 2 immune signature observed in Inuit children.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Allergy
Jessica W. Hui-Beckman, Elena Goleva, Evgeny Berdyshev, Donald Y. M. Leung
Summary: Atopic dermatitis (AD) and food allergy (FA) are closely related and one-third of AD children develop concomitant FA. Epithelial barrier dysfunction is important in both diseases. Genetic factors such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms are associated with increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA as well as activating the type 2 immune response. Comprehensive multiomic studies have identified distinct atopic endotypes with unique characteristics, providing an opportunity for improved diagnosis and prevention of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu Zhang, Nina Heinemann, Franziska Rademacher, Maxim E. Darvin, Christian Raab, Cornelia M. Keck, Henning Vollert, Joachim W. Fluhr, Regine Glaser, Jurgen Harder, Martina C. Meinke
Summary: This study investigates the effects of a natural extract rich in antioxidants on signaling inflammatory molecules and skin barrier enhancement in human epidermal keratinocytes, and analyzes its influence on lesion severity, barrier function, and pruritus in mild to moderate atopic dermatitis patients through both cell assays and a clinical study.
Review
Allergy
Peter M. Elias
Summary: This study compared the characteristics of over-the-counter moisturizers with physiological lipid-based barrier repair therapy (BRT) and found that not all moisturizers are beneficial for atopic dermatitis (AD) and some may even induce or exacerbate inflammation. In contrast, physiological lipid-based BRT can correct barrier abnormalities and reduce inflammation in AD and possibly other inflammatory skin conditions.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Immunology
Hyang Jeon, Geunyeong Kim, Ayesha Kashif, Min Hwa Hong, Ji-Sook Lee, Yujin Hong, Beom Seok Park, Eun Ju Yang, In Sik Kim
Summary: Atopic dermatitis is a chronic disease characterized by skin inflammation and barrier dysfunction, with house dust mites being key allergens. A study on Der p 38, a novel mite allergen, has shown that it triggers atopic dermatitis by reducing skin barrier proteins and increasing inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Stephanie E. Zimmer, Takuya Takeichi, Daniel E. Conway, Akiharu Kubo, Yasushi Suga, Masashi Akiyama, Andrew P. Kowalczyk
Summary: This study compares two dominant mutations in the DSG1 gene that cause different skin diseases, revealing distinct pathomechanisms of these mutations. The mutants showed differences in desmosome assembly due to reduced membrane trafficking and lipid raft targeting. The study highlights the importance of DSG1 in epidermal pathophysiology and emphasizes the need for further research on desmosomal cadherins.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Allergy
Risa Fukuda, Takeshi Ouchi, Yasuhiko Asahina, Chihiro Shiiya, Sakiko Takeuchi, Fumiyo Yasuda-Sekiguchi, Hisato Iriki, Michiyoshi Kouno, Shinichi Takahashi, Akiko Tanikawa, Masayuki Amagai, Hayato Takahashi
Summary: This study aimed to investigate the clinical utility of the basophil activation test (BAT) in diagnosing natto-induced hypersensitivity. The results showed that a 15-minute incubation period was sufficient to identify patients with natto-induced hypersensitivity and may distinguish the clinical phenotype of the hypersensitivity.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Immunology
Hisashi Nomura, Naoko Wada, Hayato Takahashi, Yuko Kase, Jun Yamagami, Shohei Egami, Hisato Iriki, Miho Mukai, Aki Kamata, Hiromi Ito, Hideki Fujii, Tomoyuki Ishikura, Haruhiko Koseki, Takashi Watanabe, Taketo Yamada, Osamu Ohara, Shigeo Koyasu, Masayuki Amagai
Summary: The study reveals that Dsg3-specific B cells in mice do not undergo spontaneous pathogenic class switching in vivo and the induction of pemphigus phenotype is prevented under normal conditions.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Dermatology
Yuko Kase, Hayato Takahashi, Hiromi Ito, Aki Kamata, Masayuki Amagai, Jun Yamagami
Summary: The study found that intravenous immunoglobulin (IVIG) treatment can reduce autoantibody secretion in a mouse model of pemphigus vulgaris (PV). This effect may be achieved by reducing B220(-) cells containing plasma cells in the spleen.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
W. L. Zhao, K. Ishii, S. Egami, Z. Xu, T. Funakoshi, H. Takahashi, A. Tanikawa, A. Ishiko, M. Amagai, J. Yamagami
Summary: This study investigated pemphigus patients who were positive for anti-Dsg IgG autoantibodies during remission, finding that some patients still had pathogenic activity of the antibodies during remission. The antibody titres decreased in remission, but did not significantly affect corticosteroid reduction and relapse rate for the patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Multidisciplinary Sciences
Kodai Abe, Yasuaki Kabe, Susumu Uchiyama, Yuka W. Iwasaki, Hirotsugu Ishizu, Yoshifumi Uwamino, Toshiki Takenouchi, Shunsuke Uno, Makoto Ishii, Takahiro Maruno, Masanori Noda, Mitsuru Murata, Naoki Hasegawa, Hideyuki Saya, Yuko Kitagawa, Koichi Fukunaga, Masayuki Amagai, Haruhiko Siomi, Makoto Suematsu, Kenjiro Kosaki
Summary: Recent clinical trial showed 3CL(pro) inhibitor significantly reduces risk of hospitalization/death, while SARS-CoV-2 sub-lineage with reduced 3CL(pro) enzymatic activity exhibits milder clinical course. Structural perturbation surrounding substrate-binding region of mutant 3CL(pro) may explain the decreased activity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Keiichiro Shiraga, Yuichi Ogawa, Shojiro Kikuchi, Masayuki Amagai, Takeshi Matsui
Summary: This study developed a high-precision measurement system to evaluate changes in bulk water content at single-cell level and found that a significant increase in bulk water content occurs during cell death, possibly triggered by calcium flux.
Article
Multidisciplinary Sciences
Sachiko Fujiwara, Thanh Phuong Nguyen, Kyoko Furuse, Yugo Fukazawa, Tetsuhisa Otani, Mikio Furuse
Summary: The interaction of claudins with ZO proteins is not a prerequisite for tight junction formation at the most apical part of cell-cell contacts.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Genetics & Heredity
Sonoko Saito, Noriko Ono, Takashi Sasaki, Satomi Aoki, Kenjiro Kosaki, Bunya Kuze, Kazuhiko Nakabayashi, Masayuki Amagai, Akiharu Kubo
Summary: This article describes a patient with severe early-onset NF2 overlapping with PRS, showing micrognathia, glossoptosis, and a mild form of cleft palate. The patient was found to have a de novo chromosome 22q12 microdeletion including MN1 and NF2.
JOURNAL OF HUMAN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Yasuhiko Asahina, Umi Tahara, Satomi Aoki, Kazuhiko Nakabayashi, Chiharu Tateishi, Daisuke Hayashi, Masayuki Amagai, Daisuke Tsuruta, Akiharu Kubo
Summary: A prenatal genetic change on the wild-type allele in an embryo with a congenital pathogenic variant allele can cause superimposed mosaicism of monoallelic and biallelic defect of the gene. We report two HHD cases with superimposed mosaicism: a congenital monoallelic pathogenic variant followed by a postzygotic copy-neutral loss of heterozygosity. Our cases showed that superimposed mosaicism in HHD can occur without a family history and genetic analysis is crucial for evaluating the risk of familial occurrence.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Letter
Dermatology
Keisuke Shimizu, Hideki Fujita, Daisuke Fujisawa, Koremasa Hayama, Satomi Aoki, Akiharu Kubo, Tadashi Terui
JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Hisato Iriki, Hayato Takahashi, Masayuki Amagai
Summary: OX40 is an important costimulatory molecule for T-cell expansion and survival, making it an attractive therapeutic target for a variety of T-cell-mediated diseases. This review explores the potential applications of OX40-targeted therapy for skin inflammatory diseases and discusses the role of OX40/OX40L-mediated interaction in skin autoimmune diseases. It also highlights the significance of understanding the impact of OX40-targeted treatment on regulatory T cells for developing therapeutic strategies for various skin diseases.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
Ayaka Ariyoshi, Takeshi Fukumoto, Shinya Imamura, Kenichiro Ohnuma, Masako Nishida, Shinya Hashimoto, Hiroshi Nagai, Akiharu Kubo
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Umi Tahara, Takeshi Matsui, Toru Atsugi, Keitaro Fukuda, Tommy W. Terooatea, Aki Minoda, Akiharu Kubo, Masayuki Amagai
Summary: This study identifies the expression of hemoglobin a (HBA) in the epidermis and suggests its role as an antioxidant contributing to skin barrier function.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)