Viral vector‐mediated Cre recombinase expression in substantia nigra induces lesions of the nigrostriatal pathway associated with perturbations of dopamine‐related behaviors and hallmarks of programmed cell death

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF

(2017) Jaakko J. Kopra et al.   JOURNAL OF NEUROSCIENCE

Role of Hypothalamic VGF in Energy Balance and Metabolic Adaption to Environmental Enrichment in Mice

(2016) Grant D. Foglesong et al.   ENDOCRINOLOGY

Adult Brain Serotonin Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas

(2016) M. S. Whitney et al.   JOURNAL OF NEUROSCIENCE

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward

(2016) M Shen et al.   Translational Psychiatry

Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress

(2015) Huijing Xia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic

(2015) Emily K. Pugach et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviors

(2015) Ivana Mesic et al.   NEUROPSYCHOPHARMACOLOGY

Cre recombinase induces DNA damage and tetraploidy in the absence ofLoxPsites

(2014) Vaibhao Janbandhu et al.   CELL CYCLE

Estrogen-Negative Feedback and Estrous Cyclicity Are Critically Dependent Upon Estrogen Receptor-α Expression in the Arcuate Nucleus of Adult Female Mice

(2014) Shel-Hwa Yeo et al.   ENDOCRINOLOGY

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Moderate and high amounts of tamoxifen in  MHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death

(2013) K. Bersell et al.   Disease Models & Mechanisms

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

(2013) Selcuk A. Tanik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ciliary Neurotrophic Factor Receptor Regulation of Adult Forebrain Neurogenesis

(2013) N. Lee et al.   JOURNAL OF NEUROSCIENCE

Mutants of Cre recombinase with improved accuracy

(2013) Nikolai Eroshenko et al.   Nature Communications

Programmed Cell Death in Parkinson's Disease

(2013) K. Venderova et al.   Cold Spring Harbor Perspectives in Medicine

Evidence for Baseline Retinal Pigment Epithelium Pathology in the Trp1-Cre Mouse

(2012) Aristomenis Thanos et al.   AMERICAN JOURNAL OF PATHOLOGY

Psychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice

(2012) Mitsunari Nakajima et al.   JOURNAL OF NEUROCHEMISTRY

The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B, and activated DNA damage response kinases

(2011) Stéphanie Solier et al.   CELL CYCLE

A novel parkin-mediated transcriptional function links p53 to familial Parkinson’s disease

(2011) Cristina Alves da Costa et al.   CELL CYCLE

Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway

(2011) Jianjian Zhu et al.   GENESIS

Compensatory Regulation of Dopamine after Ablation of the Tyrosine Hydroxylase Gene in the Nigrostriatal Projection

(2011) Hirofumi Tokuoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens

(2011) M. Lazarus et al.   JOURNAL OF NEUROSCIENCE

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction

(2011) Michael R. Bruchas et al.   NEURON

A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice

(2011) Linghua Qiu et al.   PLoS One

Brainstem and Spinal Cord Circuitry Regulating REM Sleep and Muscle Atonia

(2011) Martina Krenzer et al.   PLoS One

Suppression of endogenous PPARγ increases vulnerability to methamphetamine-induced injury in mouse nigrostriatal dopaminergic pathway

(2011) Seong-Jin Yu et al.   PSYCHOPHARMACOLOGY

Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of “floxed” alleles

(2010) Won Jae Huh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Direct Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreERT2

(2009) A. Y. Higashi et al.   JOURNAL OF IMMUNOLOGY

Recombination between inverted loxP sites is cytotoxic for proliferating cells and provides a simple tool for conditional cell ablation

(2008) D. Gregoire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY