FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

FBXO22 possesses both pro-tumorigenic and anti-metastatic roles in breast cancer progression

(2018) Rui Sun et al.   CANCER RESEARCH

Ubiquitination in melanoma pathogenesis and treatment

(2017) Jinyuan Ma et al.   Cancer Medicine

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

(2016) Wafik S. El-Deiry   CANCER RESEARCH

α-Actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of Snail expression and β-catenin stabilization in cervical cancer

(2016) H-T An et al.   ONCOGENE

SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

(2016) Yoshikazu Johmura et al.   Nature Communications

The unravelling of the ubiquitin system

(2015) Aaron Ciechanover   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells

(2014) Lin Chen et al.   Cell Communication and Signaling

Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion

(2014) J. Kim et al.   EMBO REPORTS

Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling

(2013) Lulu Liu et al.   HEPATOLOGY

CRL4Cdt2

(2011) Tarek Abbas et al.   CELL CYCLE

SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation

(2011) M.-K. M. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

Deubiquitinases in cancer: new functions and therapeutic options

(2011) J M Fraile et al.   ONCOGENE

Oncogenicras-induced Down-regulation of Autophagy Mediator Beclin-1 Is Required for Malignant Transformation of Intestinal Epithelial Cells

(2009) Byong Hoon Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

Molecular mechanisms of hepatocellular carcinoma

(2008) Rajagopal N. Aravalli et al.   HEPATOLOGY