期刊
JOURNAL OF CELL BIOLOGY
卷 218, 期 4, 页码 1148-1163出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201807228
关键词
-
类别
资金
- National Institutes of Health [GM121491, R03 HD078485, R01 GM086610]
- Lake Champlain Cancer Research Organization
- Susan G. Komen grant [CCR16377648]
- Leukemia and Lymphoma Career Development Award
- U.S. Department of Defense Peer Reviewed Cancer Research Program Horizon Award [W81XWH-17-1-0371]
- Vermont Space Grant Consortium fellowship
Chromosome alignment at the equator of the mitotic spindle is a highly conserved step during cell division; however, its importance to genomic stability and cellular fitness is not understood. Normal mammalian somatic cells lacking KIF18A function complete cell division without aligning chromosomes. These alignment-deficient cells display normal chromosome copy numbers in vitro and in vivo, suggesting that chromosome alignment is largely dispensable for maintenance of euploidy. However, we find that loss of chromosome alignment leads to interchromosomal compaction defects during anaphase, abnormal organization of chromosomes into a single nucleus at mitotic exit, and the formation of micronuclei in vitro and in vivo. These defects slow cell proliferation and are associated with impaired postnatal growth and survival in mice. Our studies support a model in which the alignment of mitotic chromosomes promotes proper organization of chromosomes into a single nucleus and continued proliferation by ensuring that chromosomes segregate as a compact mass during anaphase.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据