Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners

Genome-wide tracking of dCas9-methyltransferase footprints

(2018) Christina Galonska et al.   Nature Communications

DNMT3AR882-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3AR882C OCI-AML3 leukemia cell line

(2018) David Chen et al.   Blood Cancer Journal

DOT1L as a therapeutic target for the treatment of DNMT3A -mutant acute myeloid leukemia

(2016) Rachel E. Rau et al.   BLOOD

3CAPS – a structural AP–site analogue as a tool to investigate DNA base excision repair

(2016) David Schuermann et al.   NUCLEIC ACIDS RESEARCH

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer

(2016) C Stirzaker et al.   ONCOGENE

Mutations in epigenetic modifiers in acute myeloid leukemia and their clinical utility

(2016) Hsin-An Hou et al.   Expert Review of Hematology

DNA methylation pathways and their crosstalk with histone methylation

(2015) Jiamu Du et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers

(2014) David A. Russler-Germain et al.   CANCER CELL

DNA damage accumulation and repair defects in acute myeloid leukemia: implications for pathogenesis, disease progression, and chemotherapy resistance

(2014) Maria Teresa Esposito et al.   CHROMOSOMA

Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated byDNMT3Amutational status and associated with predominant hypomethylation of HOX genes

(2014) Ying Qu et al.   Epigenetics

RNA-directed DNA methylation: an epigenetic pathway of increasing complexity

(2014) Marjori A. Matzke et al.   NATURE REVIEWS GENETICS

The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations inRUNX1andDNMT3Aare associated with poor prognosis in T-ALL

(2013) Vera Grossmann et al.   GENES CHROMOSOMES & CANCER

Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation

(2012) Celeste Holz-Schietinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β-Dependent Active Demethylation and Expression of the p15ink4b Tumor Suppressor Are Impaired by the ZNF217/CoREST Complex

(2012) Gobi Thillainadesan et al.   MOLECULAR CELL

TET2andDNMT3AMutations in Human T-Cell Lymphoma

(2012) Lucile Couronné et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia

(2011) Norio Shiba et al.   BRITISH JOURNAL OF HAEMATOLOGY

Oligomerization of DNMT3A Controls the Mechanism ofde NovoDNA Methylation

(2011) Celeste Holz-Schietinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNMT3A mutations in myeloproliferative neoplasms

(2011) F Stegelmann et al.   LEUKEMIA

Identification of a second DNA binding site in human DNA methyltransferase 3A by substrate inhibition and domain deletion

(2010) Matthew M. Purdy et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Epigenetics in AML

(2010) Ari M. Melnick   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation

(2010) Eric Hervouet et al.   Epigenetics

Dynamic changes in the human methylome during differentiation

(2010) L. Laurent et al.   GENOME RESEARCH

The Inherent Processivity of the Humande NovoMethyltransferase 3A (DNMT3A) Is Enhanced by DNMT3L

(2010) Celeste Holz-Schietinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD