Modulation of SPARC/Hevin Proteins in Alzheimer’s Disease Brain Injury

Implication of SPARC in the modulation of the extracellular matrix and mitochondrial function in muscle cells

(2018) Aicha Melouane et al.   PLoS One

SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury

(2018) Emma V. Jones et al.   Frontiers in Cellular Neuroscience

The Upregulation of Integrin αDβ2(CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis

(2017) Moammir H. Aziz et al.   JOURNAL OF IMMUNOLOGY

SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex

(2017) S-J Zhao et al.   ONCOGENE

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Activation of Microglia by Histamine and Substance P

(2017) Jin Zhu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

CCR7 deficient inflammatory Dendritic Cells are retained in the Central Nervous System

(2017) Benjamin D. Clarkson et al.   Scientific Reports

Major amyloid-β–degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex

(2016) Javier Pacheco-Quinto et al.   NEUROBIOLOGY OF AGING

A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth

(2016) Katrina Viloria et al.   Scientific Reports

Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization

(2015) Hiroe Toba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Loss ofSparcinp53-null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival

(2015) Stacey L. Thomas et al.   BRAIN PATHOLOGY

Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9

(2015) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

(2015) Levi B. Wood et al.   Scientific Reports

The Potential Role of Chemokines in Alzheimer’s Disease Pathogenesis

(2014) Gholamreza Azizi et al.   American Journal of Alzheimers Disease and Other Dementias

Analysis of microglial migration by a micropipette assay

(2014) Hang-jun Wu et al.   Nature Protocols

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease

(2014) Emma V. Jones et al.   NEURAL PLASTICITY

Systemic immune system alterations in early stages of Alzheimer's disease

(2013) Rongzhen Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia

(2013) S. M. Lloyd-Burton et al.   JOURNAL OF NEUROSCIENCE

Brain dendritic cells: biology and pathology

(2012) Paul M. D’Agostino et al.   ACTA NEUROPATHOLOGICA

Diverse biological functions of the SPARC family of proteins

(2012) Amy D. Bradshaw   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Matricellular Proteins in Cardiac Adaptation and Disease

(2012) Nikolaos G. Frangogiannis   PHYSIOLOGICAL REVIEWS

Cerebral Amyloid Angiopathy: A Systematic Review

(2011) Alessandro Biffi et al.   Journal of Clinical Neurology

SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS

(2011) Samantha Lloyd-Burton et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Astrocytes Control Glutamate Receptor Levels at Developing Synapses through SPARC- -Integrin Interactions

(2011) E. V. Jones et al.   JOURNAL OF NEUROSCIENCE

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

(2011) Hakan Kucukdereli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages in Alzheimer’s disease: the blood-borne identity

(2010) David Gate et al.   JOURNAL OF NEURAL TRANSMISSION

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Microglia

(2010) Julia Kofler et al.   TOXICOLOGIC PATHOLOGY

Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood–brain barrier disruption after global cerebral ischemia

(2009) Ewa Baumann et al.   BRAIN RESEARCH

Processing of the Matricellular Protein Hevin in Mouse Brain Is Dependent on ADAMTS4

(2009) Matt S. Weaver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of astrocyte-secreted matricellular proteins in central nervous system development and function

(2009) Cagla Eroglu   Journal of Cell Communication and Signaling

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY

SPARC is expressed by macroglia and microglia in the developing and mature nervous system

(2008) Adele J. Vincent et al.   DEVELOPMENTAL DYNAMICS

Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease

(2008) Tarja M. Malm et al.   GLIA

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE