Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways
出版年份 2019 全文链接
标题
Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways
作者
关键词
-
出版物
JOURNAL OF ALZHEIMERS DISEASE
Volume 68, Issue 2, Pages 657-668
出版商
IOS Press
发表日期
2019-02-13
DOI
10.3233/jad-180906
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Evidence for brain glucose dysregulation in Alzheimer's disease
- (2018) Yang An et al. Alzheimers & Dementia
- Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise
- (2018) Christopher H. van Dyck BIOLOGICAL PSYCHIATRY
- The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease
- (2018) David C. Schöndorf et al. Cell Reports
- Systematic Literature Review and Meta-Analysis of Diagnostic Test Accuracy in Alzheimer's Disease and Other Dementia Using Autopsy as Standard of Truth
- (2018) Sandrine Cure et al. JOURNAL OF ALZHEIMERS DISEASE
- Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes
- (2018) Tze Pin Ng et al. JOURNAL OF ALZHEIMERS DISEASE
- Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines
- (2018) Brian R. Ott et al. Frontiers in Aging Neuroscience
- Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy
- (2017) Peter M LoCoco et al. eLife
- Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults
- (2017) Mark A. Reger et al. JOURNAL OF ALZHEIMERS DISEASE
- Epidemiological Trends Strongly Suggest Exposures as Etiologic Agents in the Pathogenesis of Sporadic Alzheimer's Disease, Diabetes Mellitus, and Non-Alcoholic Steatohepatitis
- (2017) Suzanne M. de la Monte et al. JOURNAL OF ALZHEIMERS DISEASE
- Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke
- (2016) Shu-Na Wang et al. CNS Neuroscience & Therapeutics
- Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease
- (2016) Suzanne M. de la Monte DRUGS
- Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology
- (2016) Antonella Tramutola et al. Expert Review of Neurotherapeutics
- Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer’s Disease
- (2016) Suzanne M. de la Monte et al. JOURNAL OF ALZHEIMERS DISEASE
- The incretin system ABCs in obesity and diabetes - novel therapeutic strategies for weight loss and beyond
- (2016) A. L. João et al. Obesity Reviews
- Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies
- (2016) James Yarmolinsky et al. Scientific Reports
- A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes
- (2016) Heshan Peiris et al. PLoS Genetics
- Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology
- (2016) Antonella Tramutola et al. Expert Review of Neurotherapeutics
- Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis
- (2015) Kirsten L. Viola et al. ACTA NEUROPATHOLOGICA
- Biomarkers of Alzheimer's disease and mild cognitive impairment: A current perspective
- (2015) Piotr Lewczuk et al. Advances in Medical Sciences
- Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease
- (2015) Robert Baranello et al. Current Alzheimer Research
- Targeting Insulin Signaling for the Treatment of Alzheimer's Disease
- (2015) Yanxing Chen et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Nampt/PBEF/Visfatin Exerts Neuroprotective Effects Against Ischemia/Reperfusion Injury via Modulation of Bax/Bcl-2 Ratio and Prevention of Caspase-3 Activation
- (2015) Sohaila Erfani et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment
- (2015) Xiaohua Li et al. Clinical Interventions in Aging
- Biological markers of Alzheimer?s disease
- (2014) Leonardo Cruz de Souza et al. ARQUIVOS DE NEURO-PSIQUIATRIA
- Brain metabolic dysfunction at the core of Alzheimer's disease
- (2014) Suzanne M. de la Monte et al. BIOCHEMICAL PHARMACOLOGY
- Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain
- (2014) D. Allan Butterfield et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- White Matter Hypoperfusion and Damage in Dementia: Post-Mortem Assessment
- (2014) Seth Love et al. BRAIN PATHOLOGY
- Extracellular Visfatin has Nicotinamide Phosphoribosyltransferase Enzymatic Activity and is Neuroprotective Against Ischemic Injury
- (2014) Yan Zhao et al. CNS Neuroscience & Therapeutics
- Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease
- (2014) Mirjana Babić et al. CROATIAN MEDICAL JOURNAL
- Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review
- (2014) Suzanne M. de la Monte EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Neuronal NAMPT is Released after Cerebral Ischemia and Protects against White Matter Injury
- (2014) Zheng Jing et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Amyloid-ß-directed immunotherapy for Alzheimer's disease
- (2014) L. Lannfelt et al. JOURNAL OF INTERNAL MEDICINE
- Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer’s disease
- (2014) Natalia N. Nalivaeva et al. Frontiers in Aging Neuroscience
- Visfatin is involved in TNFα-mediated insulin resistance via an NAD+/Sirt1/PTP1B pathway in 3T3-L1 adipocytes
- (2014) Erwan Gouranton et al. Adipocyte
- Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
- (2013) Jessica Freiherr et al. CNS DRUGS
- Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art
- (2013) Suzanne M de la Monte Expert Opinion on Drug Delivery
- Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease
- (2012) Suzanne M. de la Monte Current Alzheimer Research
- Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans
- (2012) K. Jauch-Chara et al. DIABETES
- Increased Expression of the Glucose-Responsive Gene,RCAN1, Causes Hypoinsulinemia, β-Cell Dysfunction, and Diabetes
- (2012) Heshan Peiris et al. ENDOCRINOLOGY
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- Clinical Validation of 18F-AZD4694, an Amyloid- -Specific PET Radioligand
- (2012) Z. Cselenyi et al. JOURNAL OF NUCLEAR MEDICINE
- Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study
- (2012) Adam S Fleisher et al. LANCET NEUROLOGY
- Plasminogen Activator Inhibitor-1 and Thrombotic Cerebrovascular Diseases
- (2012) Anna Tjärnlund-Wolf et al. STROKE
- Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Reisa A. Sperling et al. Alzheimers & Dementia
- The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Guy M. McKhann et al. Alzheimers & Dementia
- Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway
- (2011) Pei Wang et al. ANNALS OF NEUROLOGY
- Insulin resistance and Alzheimer's disease
- (2011) Suzanne M. De La Monte BMB Reports
- Insulin resistance and pathological brain ageing
- (2011) B. Cholerton et al. DIABETIC MEDICINE
- Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease
- (2011) Suzanne M. de la Monte DRUGS
- si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder
- (2011) Suzanne M de la Monte et al. Molecular Brain
- Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?
- (2010) Nigel Irwin et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Immunotherapy for Alzheimer’s disease
- (2010) D. Morgan JOURNAL OF INTERNAL MEDICINE
- Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer’s brain
- (2010) Suqing Wang et al. JOURNAL OF NEUROCHEMISTRY
- Visfatin, glucose metabolism and vascular disease: a review of evidence
- (2010) Pedro Saddi-Rosa et al. Diabetology & Metabolic Syndrome
- Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity
- (2009) James Scott Miners et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- INTRANASAL INSULIN IMPROVES COGNITION AND MODULATES -AMYLOID IN EARLY AD
- (2009) M. S. Dhamoon et al. NEUROLOGY
- Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial
- (2008) H Schmidt et al. JOURNAL OF MEDICAL GENETICS
- Dietary intervention in older adults with early-stage Alzheimer Dementia: Early lessons learned
- (2008) B. Shatenstein et al. Journal of Nutrition Health & Aging
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started