Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer’s Disease

Drug development for Alzheimer’s disease: review

(2018) Kejing Lao et al.   JOURNAL OF DRUG TARGETING

Altered expression of glutamate transporter-1 and water channel protein aquaporin-4 in human temporal cortex with Alzheimer's disease

(2018) A. Hoshi et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Region- and Age-Specific Changes in Glutamate Transport in the AβPP23 Mouse Model for Alzheimer's Disease

(2018) Anneleen Schallier et al.   JOURNAL OF ALZHEIMERS DISEASE

GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model

(2018) Paramita Mookherjee et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β42 Proxy, Amyloid-β25-35, Induces Normal Human Cerebral Astrocytes to Produce Amyloid-β42

(2018) Ilaria Dal Prà et al.   JOURNAL OF ALZHEIMERS DISEASE

Coffee Intake in Midlife and Risk of Dementia and its Neuropathologic Correlates

(2018) Rebecca P. Gelber et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytic Adenosine A2A Receptors Control the Amyloid-β Peptide-Induced Decrease of Glutamate Uptake

(2018) Marco Matos et al.   JOURNAL OF ALZHEIMERS DISEASE

Picomolar Amyloid-β Peptides Enhance Spontaneous Astrocyte Calcium Transients

(2018) Linda Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

Glutamatergic Dysfunctioning in Alzheimer's Disease and Related Therapeutic Targets

(2018) Dénes Zádori et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

(2017) Anna Chiarini et al.   Frontiers in Neuroscience

Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study

(2017) Marjo H. Eskelinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer's Disease Mice

(2017) Gary W. Arendash et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic Caffeine Consumption Prevents Memory Disturbance in Different Animal Models of Memory Decline

(2017) Rodrigo A. Cunha et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Intake and Dementia: Systematic Review and Meta-Analysis

(2017) Catarina Santos et al.   JOURNAL OF ALZHEIMERS DISEASE

Calcium-Sensing Receptor Antagonist NPS 2143 Restores Amyloid Precursor Protein Physiological Non-Amyloidogenic Processing in Aβ-Exposed Adult Human Astrocytes

(2017) Anna Chiarini et al.   Scientific Reports

The calcium-sensing receptor and the hallmarks of cancer

(2016) Samawansha Tennakoon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism

(2016) Rosario Gajardo-Gómez et al.   GLIA

Schisantherin B ameliorates Aβ 1–42 -induced cognitive decline via restoration of GLT-1 in a mouse model of Alzheimer's disease

(2016) Mengjie Xu et al.   PHYSIOLOGY & BEHAVIOR

The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer’s Disease

(2016) Yu-Long Lan et al.   NEURAL PLASTICITY

Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease

(2016) Anna Chiarini et al.   Frontiers in Physiology

NO2 inhalation promotes Alzheimer’s disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication

(2016) Wei Yan et al.   Scientific Reports

Glutamate Synapses in Human Cognitive Disorders

(2015) Lenora Volk et al.   Annual Review of Neuroscience

Effects of glutamate and its metabotropic receptors class 1 antagonist in appetitive taste memory formation

(2015) Leticia Ramírez-Lugo et al.   BEHAVIOURAL BRAIN RESEARCH

Allosteric modulation of nicotinic acetylcholine receptors

(2015) Anna Chatzidaki et al.   BIOCHEMICAL PHARMACOLOGY

mGluR5 protect astrocytes from ischemic damage in postnatal CNS white matter

(2015) Ilaria Vanzulli et al.   CELL CALCIUM

Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human Astrocytes

(2015) Xiaojuan Han et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Alzheimer’s Disease, Astrocytes and Kynurenines

(2015) Livia Dezsi et al.   Current Alzheimer Research

Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization

(2015) Carlos Pomilio et al.   HIPPOCAMPUS

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

(2015) Kou Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Antagonizing amyloid-β/calcium-sensing receptor signaling in human astrocytes and neurons: a key to halt Alzheimer′s disease progression?

(2015) Ubaldo Armato et al.   Neural Regeneration Research

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology of Alzheimer’s Disease

(2015) Carolyn C. Rudy et al.   Aging and Disease

Therapeutic potential of mGluR5 targeting in Alzheimer's disease

(2015) Anil Kumar et al.   Frontiers in Neuroscience

WIN 55,212-2, Agonist of Cannabinoid Receptors, Prevents Amyloid β1-42 Effects on Astrocytes in Primary Culture

(2015) Diana Aguirre-Rueda et al.   PLoS One

Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer’s Disease

(2014) I. Pra et al.   Current Neuropharmacology

Glutamate as a neurotransmitter in the healthy brain

(2014) Y. Zhou et al.   JOURNAL OF NEURAL TRANSMISSION

Intracellular mGluR5 Can Mediate Synaptic Plasticity in the Hippocampus

(2014) C. A. Purgert et al.   JOURNAL OF NEUROSCIENCE

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

(2014) Ilaria Dal Prà et al.   NEUROMOLECULAR MEDICINE

The calcium sensing receptor life cycle: Trafficking, cell surface expression, and degradation

(2013) Gerda E. Breitwieser   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

(2013) Ubaldo Armato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

(2013) Zaira Esposito et al.   CNS Neuroscience & Therapeutics

Astrocytes revisited: concise historic outlook on glutamate homeostasis and signaling

(2013) Vladimir Parpura et al.   CROATIAN MEDICAL JOURNAL

On the Interaction of β-Amyloid Peptides and α7-Nicotinic Acetylcholine Receptors in Alzheimer’s Disease

(2013) Murat Oz et al.   Current Alzheimer Research

β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors

(2013) Amulya Nidhi Shrivastava et al.   GLIA

Amyloid- 1-42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1

(2013) A. Scimemi et al.   JOURNAL OF NEUROSCIENCE

Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: Implications for neuropsychiatric diseases

(2013) Hong Lin et al.   NEUROBIOLOGY OF DISEASE

α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model

(2013) Tiina Maria Pirttimaki et al.   PLoS One

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

(2013) A A Grolla et al.   Cell Death & Disease

Calcium sensing receptor signalling in physiology and cancer

(2012) Sarah C. Brennan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes

(2012) Marco Matos et al.   GLIA

Alzheimer’s disease: An update of the roles of receptors, astrocytes and primary cilia (Review)

(2012) UBALDO ARMATO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency

(2012) Jiang Wu et al.   NEUROBIOLOGY OF AGING

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

(2012) Rongqing Chen et al.   Cell Reports

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

(2011) Dustin K. Williams et al.   BIOCHEMICAL PHARMACOLOGY

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

(2011) Chuanyu Li et al.   Current Alzheimer Research

Adenosine and ATP Receptors in the Brain

(2011) Geoffrey Burnstock et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Adenosine A2A receptor in the monkey basal ganglia: Ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum

(2011) James W. Bogenpohl et al.   JOURNAL OF COMPARATIVE NEUROLOGY

α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling

(2011) Wenfeng Yu et al.   JOURNAL OF NEUROCHEMISTRY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults

(2011) X. Chen et al.   NEUROSCIENCE

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

(2011) Giuseppe Esposito et al.   PLoS One

mGluR5 in Cortical Excitatory Neurons Exerts Both Cell-Autonomous and -Nonautonomous Influences on Cortical Somatosensory Circuit Formation

(2010) C. J. Ballester-Rosado et al.   JOURNAL OF NEUROSCIENCE

Loss of  7 Nicotinic Receptors Enhances  -Amyloid Oligomer Accumulation, Exacerbating Early-Stage Cognitive Decline and Septohippocampal Pathology in a Mouse Model of Alzheimer's Disease

(2010) C. M. Hernandez et al.   JOURNAL OF NEUROSCIENCE

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

Astrocytic dysfunction: Insights on the role in neurodegeneration

(2009) Daniela Rossi et al.   BRAIN RESEARCH BULLETIN

Neuroglia in neurodegeneration

(2009) Michael T. Heneka et al.   BRAIN RESEARCH REVIEWS

Calcium-Sensing Receptor (CaSR) in Human Brains Pathophysiology: Roles in Late-Onset Alzheimers Disease (LOAD)

(2009) Anna Chiarini et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment

(2009) Rukhsana Sultana et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Adenosine A2A receptor mediates microglial process retraction

(2009) Anna G Orr et al.   NATURE NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions

(2009) Anna Chiarini et al.   PROTEOMICS

Evidence supporting a role for the calcium-sensing receptor in Alzheimer disease

(2008) Yvette P. Conley et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

RESEARCH ARTICLE: Up-regulation of Adenosine Receptors in the Frontal Cortex in Alzheimer's Disease

(2008) José L. Albasanz et al.   BRAIN PATHOLOGY

Caffeine, cognitive failures and health in a non-working community sample

(2008) Andrew P Smith   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells

(2008) Giuseppe Esposito et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease

(2008) Xuesong Chen et al.   Journal of Neuroinflammation

Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

(2008) Nelson Rebola et al.   NEURON

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

(2008) M. Matos et al.   NEUROSCIENCE

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression

(2007) G Esposito et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies

(2007) Reinaldo Naoto Takahashi   Frontiers in Bioscience-Landmark