Modified ingenol semi-synthetic derivatives from Euphorbia tirucalli induce cytotoxicity on a large panel of human cancer cell lines

Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells

(2018) Viviane A. O. Silva et al.   INVESTIGATIONAL NEW DRUGS

In�vitro screening of cytotoxic activity of euphol from Euphorbia�tirucalli on a large panel of human cancer‑derived cell lines

(2018) Viviane Silva et al.   Experimental and Therapeutic Medicine

Ingenol-3-Angelate Suppresses Growth of Melanoma Cells and Skin Tumor Development by Downregulation of NF-κB-Cox2 Signaling

(2018) Dunwei Wang et al.   MEDICAL SCIENCE MONITOR

Euphorbia neriifolia L.: Review on botany, ethnomedicinal uses, phytochemistry and biological activities

(2017) Prashant Y. Mali et al.   Asian Pacific Journal of Tropical Medicine

Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives

(2016) Rafael C. Dutra et al.   PHARMACOLOGICAL RESEARCH

Isolation, characterization and screening of the in vitro cytotoxic activity of a novel L-amino acid oxidase (LAAOcdt) from Crotalus durissus terrificus venom on human cancer cell lines

(2016) Tuila Leveghim Teixeira et al.   TOXICON

Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker

(2016) Renato José Silva-Oliveira et al.   CELLULAR ONCOLOGY

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

(2015) Corina E. Antal et al.   CELL

The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε

(2015) R.C. Dutra et al.   NEUROSCIENCE

Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ–NF-κB signaling

(2014) Guochun Jiang et al.   AIDS

The value of nature's natural product library for the discovery of New Chemical Entities: The discovery of ingenol mebutate

(2014) Steven M. Ogbourne et al.   FITOTERAPIA

Dual Role of Novel Ingenol Derivatives from Euphorbia tirucalli in HIV Replication: Inhibition of De Novo Infection and Activation of Viral LTR

(2014) Celina M. Abreu et al.   PLoS One

14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

(2013) L. Jorgensen et al.   SCIENCE

The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice

(2012) Giselle F. Passos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Ingenol Mebutate Gel for Actinic Keratosis

(2012) Mark Lebwohl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unique In Vitro and In Vivo Thrombopoietic Activities of Ingenol 3,20 Dibenzoate, A Ca++-Independent Protein Kinase C Isoform Agonist

(2012) Frederick K. Racke et al.   PLoS One

Euphol prevents experimental autoimmune encephalomyelitis in mice: Evidence for the underlying mechanisms

(2011) Rafael Cypriano Dutra et al.   BIOCHEMICAL PHARMACOLOGY

PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: Results of a randomized phase IIa trial

(2010) Greg Siller et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: Results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study

(2009) Greg Siller et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Activity of the multikinase inhibitor dasatinib against ovarian cancer cells

(2009) G E Konecny et al.   BRITISH JOURNAL OF CANCER

Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells

(2008) M. Serova et al.   MOLECULAR CANCER THERAPEUTICS