Inducible Loss of the Aryl Hydrocarbon Receptor Activates Perigonadal White Fat Respiration and Brown Fat Thermogenesis via Fibroblast Growth Factor 21

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

(2019) Steven A. Kliewer et al.   Cell Metabolism

Quantification of UCP1 function in human brown adipose tissue

(2017) Craig Porter   Adipocyte

Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression

(2016) Nathaniel G. Girer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Morphological Changes in Subcutaneous White Adipose Tissue After Severe Burn Injury

(2016) Manish Kumar Saraf et al.   Journal of Burn Care & Research

Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1

(2016) Benjamin J. Moyer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption

(2015) Xunde Wang et al.   Cell Metabolism

Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21

(2015) Peipei Lu et al.   HEPATOLOGY

Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure

(2015) C-X Xu et al.   INTERNATIONAL JOURNAL OF OBESITY

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

(2015) Yan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1

(2015) Michelle M. Kwon et al.   Cell Reports

Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD

(2015) Takeshi Inagaki   Frontiers in Endocrinology

Circulating IGFBP-2 levels are incrementally linked to correlates of the metabolic syndrome and independently associated with VLDL triglycerides

(2014) Sophie Carter et al.   ATHEROSCLEROSIS

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR)

(2014) Xingguo Cheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes

(2013) Kinyui Alice Lo et al.   BIOSCIENCE REPORTS

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

(2013) João Paulo G. Camporez et al.   ENDOCRINOLOGY

Retinoic Acid Receptor β Stimulates Hepatic Induction of Fibroblast Growth Factor 21 to Promote Fatty Acid Oxidation and Control Whole-body Energy Homeostasis in Mice

(2013) Yu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomarker Discovery for Early Detection of Hepatocellular Carcinoma in Hepatitis C–infected Patients

(2013) Mehnaz G. Mustafa et al.   MOLECULAR & CELLULAR PROTEOMICS

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319

(2013) Alexei Kharitonenkov et al.   PLoS One

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

(2013) Andrew C. Adams et al.   PLoS One

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

(2012) Timothy V. Beischlag et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis

(2012) A. Rajwani et al.   DIABETES

Obesity Is Mediated by Differential Aryl Hydrocarbon Receptor Signaling in Mice Fed a Western Diet

(2012) Joanna S. Kerley-Hamilton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood

(2012) Tara L Conforto et al.   Biology of Sex Differences

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

(2010) Mary D. L. Chau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism

(2009) Y. Macotela et al.   DIABETES

Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

(2009) Eric D. Berglund et al.   ENDOCRINOLOGY

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

(2009) Katsumi Iizuka et al.   FEBS LETTERS

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

The Angiopoietin-like Proteins ANGPTL3 and ANGPTL4 Inhibit Lipoprotein Lipase Activity through Distinct Mechanisms

(2008) Lu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY