Article
Radiology, Nuclear Medicine & Medical Imaging
Yarong Yu, Wenli Yang, Xu Dai, Lihua Yu, Ziting Lan, Xiaoying Ding, Jiayin Zhang
Summary: This study investigated the incidence of microvascular myocardial ischemia in diabetic patients without obstructive coronary artery disease (CAD) and its relationship with angina. Dynamic computed tomography-myocardial perfusion imaging and coronary computed tomography angiography were used to assess coronary stenosis, myocardial blood flow, and extracellular volume. The results showed a high incidence of microvascular myocardial ischemia in diabetic patients without obstructive CAD, which was strongly associated with angina.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Instruments & Instrumentation
Mengmeng Zhu, Yujie Gao, Jun Wang, Yingqian Ge, Yinsu Zhu, Xiaomei Zhu, Yi Xu
Summary: The feasibility of using CCTA-derived strain parameters to detect regional myocardial dysfunction in CAD patients with preserved LVEF was evaluated. Radial and circumferential strain have the potential ability to distinguish myocardial ischemia from infarction, and normal from ischemic myocardium.
JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Dries Belsack, Yuji Nagatomo, Mayuko Tsugu, Jean-Francois Argacha, Bernard Cosyns, Nico Buls, Michel De Maeseneer, Johan De Mey
Summary: In non-obstructive coronary artery disease, the decline of CT-derived fractional flow reserve (FFRCT) depends not only on vessel length but also on the lumen volume. A new marker, the ratio of lumen volume to vessel length (V/L ratio), was found to be the strongest predictor of distal FFRCT.
EUROPEAN RADIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xia Wu, Fei Yang, Lili Sun
Summary: This study evaluated the characteristics and influencing factors of computed tomography myocardial perfusion imaging (CT-MPI) in patients with left ventricular hypertrophy (LVH) caused by hypertension. The results showed that patients with LVH had lower myocardial blood flow but stable myocardial blood volume. In hypertensive patients, decreased myocardial blood flow was significantly correlated with increased left ventricular mass index.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Sophie E. van Rosendael, Alexander R. van Rosendael, Jurrien H. Kuneman, Manesh R. Patel, Bjarne Linde Norgaard, Timothy A. Fairbairn, Koen Nieman, Takashi Akasaka, Daniel S. Berman, Lynne M. Hurwitz Koweek, Gianluca Pontone, Tomohiro Kawasaki, Niels Peter Ronnow Sand, Jesper M. Jensen, Tetsuya Amano, Michael Poon, Kristian A. Ovrehus, Jeroen Sonck, Mark G. Rabbat, Campbell Rogers, Hitoshi Matsuo, Jonathon A. Leipsic, Ajmone Marsan, J. Wouter Jukema, Jeroen J. Bax, Antti Saraste, Juhani Knuuti
Summary: The V/M ratio assessed by CCTA is a new parameter to investigate the relation of coronary vasculature to the myocardium supplied. Hypertension decreases this ratio by way of myocardial hypertrophy, which could explain the detected abnormal myocardial perfusion reserve in patients with hypertension.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Georgios Benetos, Dominik C. Benz, Georgios P. Rampidis, Andreas A. Giannopoulos, Elia von Felten, Adam Bakula, Aleksandra Sustar, Tobias A. Fuchs, Aju P. Pazhenkottil, Catherine Gebhard, Philipp A. Kaufmann, Christoph Grani, Ronny R. Buechel
Summary: CAVi, derived from CCTA, is proposed as an indicator of diffuse atherosclerosis. This study found that CAVi is moderately correlated with stress MBF and MFR, and has incremental value in predicting abnormal stress MBF and ischemia compared to CCTA alone.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Caroline A. Berge, Ingeborg Eskerud, Elise B. Almeland, Terje H. Larsen, Eva R. Pedersen, Svein Rotevatn, Mai Tone Lonnebakken
Summary: This study aimed to investigate the association between hypertension and extensive non-obstructive coronary artery disease (CAD) in patients with symptomatic chronic coronary syndrome (CCS). The results showed that hypertension was associated with extensive non-obstructive CAD in CCS patients, independent of factors such as sex, age, smoking, diabetes, statin treatment, obesity, and calcium score.
Article
Multidisciplinary Sciences
Zengfa Huang, Beibei Cao, Xinyu Du, Mei Li, Jiong Huang, Zuoqin Li, Jianwei Xiao, Xiang Wang
Summary: We aimed to predict the risk of major adverse cardiovascular events (MACE) in patients with suspected non-obstructive coronary artery disease (CAD) by exploring classifications based on coronary computed tomography angiography (CTA). We compared these classifications with traditional non-obstructive CAD (NOCAD) classification, Duke prognostic NOCAD index, and Non-obstructive coronary artery disease reporting and data system (NOCAD-RADS). 4378 consecutive non-obstructive CAD patients were assessed, and the SPI classification, which focused on proximal involvement of plaques, provided important prognostic information for MACE prediction.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Francesco Radico, Augusto Di Castelnuovo, Alberto Aimo, Marco Zimarino, Juhani Knuuti, Serena Rossi, Luigi Emilio Pastormerlo, Luc Zyw, Enrico Orsini, Licia Iacoviello, Danilo Neglia, Michele Emdin, Giovanni de Gaetano, Raffaele De Caterina
Summary: The prognosis of angina patients without obstructive coronary artery disease (CAD) is heterogeneous, with non-obstructive CAD and myocardial ischemia at imaging tests both conferring a higher risk of cardiovascular events.
JOURNAL OF INTERNAL MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Pawel Gac, Piotr Macek, Andrzej Szczepanski, Rafal Poreba
Summary: Mechanical complications such as left ventricular rupture are rare in myocardial infarction, occurring in about 2-4% of patients. It is important to be aware of the risk of such complications during the diagnostic and therapeutic process.
Article
Physiology
Zitian Wang, Xue Zhao, Lifang Bu, Kun Liu, Ziping Li, Huaxing Zhang, Xiaoguang Zhang, Fang Yuan, Sheng Wang, Zan Guo, Luo Shi
Summary: The purpose of this study was to investigate the effects of sodium restriction on hypertension and left ventricular hypertrophy in a mouse model of primary aldosteronism. The study found that adult male mice with genetic deletion of TWIK-related acid-sensitive K-1 and TASK-3 channels exhibited hypertension and LV hypertrophy, which were ameliorated by a low-sodium intake. Untargeted metabolomics analysis revealed disturbances in heart metabolism in these mice, some of which were reversed after sodium restriction. These findings suggest that sodium restriction may play a role in preventing or reducing hypertension and LV hypertrophy in individuals with primary aldosteronism.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Medicine, General & Internal
Agata Zdanowicz, Maciej Guzinski, Michal Pula, Agnieszka Witkowska, Krzysztof Reczuch
Summary: Coronary computed tomography angiography (CTA) is a widely used non-invasive diagnostic method for suspected coronary artery disease. However, it lacks information on the hemodynamic significance of the coronary lesion. The combination of stress dynamic CT perfusion with CTA provides both anatomical and functional information and has been validated in clinical studies. CT perfusion has comparable accuracy to PET and MRI, and superior performance to SPECT in diagnosing hemodynamically significant coronary stenosis. CTP-derived perfusion has a strong correlation with FFR and can reduce unnecessary catheterizations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Tomasz K. Bednarski, Monika K. Duda, Pawel Dobrzyn
Summary: Disturbances in cardiac lipid metabolism are associated with the development of cardiac hypertrophy and heart failure in spontaneously hypertensive rats. Triglyceride accumulation in cardiomyocytes, due to lower rates of lipolysis and beta-oxidation, is linked to the development of left ventricular hypertrophy and myocardial dysfunction in SHR.
Article
Cardiac & Cardiovascular Systems
Fay M. A. Nous, Tobias Geisler, Mariusz B. P. Kruk, Hatem Alkadhi, Kakuya Kitagawa, Rozemarijn Vliegenthart, Michaela M. Hell, Jorg Hausleiter, Patricia K. Nguyen, Ricardo P. J. Budde, Konstantin Nikolaou, Cezary Kepka, Robert Manka, Hajime Sakuma, Sachin B. Malik, Adriaan Coenen, Felix Zijlstra, Ernst Klotz, Pim van der Harst, Christoph Artzner, Admir Dedic, Francesca Pugliese, Fabian Bamberg, Koen Nieman
Summary: In this multicenter study, the combination of dynamic stress CT myocardial perfusion imaging (CT-MPI) with coronary CT angiography (CTA) showed incremental diagnostic value for the identification of hemodynamically significant coronary artery disease.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Elisangela C. P. Lopes, Layde R. Paim, Luis F. R. S. Carvalho-Romano, Edmilson R. Marques, Eduarda O. Z. Minin, Camila F. L. Vegian, Jose A. Pio-Magalhaes, Licio A. Velloso, Otavio R. Coelho-Filho, Andrei C. Sposito, Jose R. Matos-Souza, Wilson Nadruz, Roberto Schreiber
Summary: This study evaluated the relationship between circulating miRNAs and left ventricular hypertrophy (LVH) in hypertensive patients. The results showed that miR-145-5p, miR-451, and let7c were independently associated with LVH and left ventricular mass index. These miRNAs were also found to regulate genes and pathways related to cardiac remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
H. Halland, M. T. Lonnebakken, N. Pristaj, S. Saeed, H. Midtbo, E. Einarsen, E. Gerdts
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2018)
Letter
Peripheral Vascular Disease
Giovanni de Simone, Costantino Mancusi, Mai T. Lonnebakken, Eva Gerdts
JOURNAL OF HYPERTENSION
(2018)
Article
Cardiac & Cardiovascular Systems
M. T. Lonnebakken, C. Mancusi, M. A. Losi, E. Gerdts, R. Izzo, M. Manzi, N. De Luca, G. de Simone, B. Trimarco
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2019)
Article
Cardiac & Cardiovascular Systems
Edda Bahlmann, Dana Cramariuc, Sahrai Saeed, John B. Chambers, Christoph A. Nienaber, Karl-Heinz Kuck, Mai Tone Lonnebakken, Eva Gerdts
Article
Cardiac & Cardiovascular Systems
H. Halland, K. Matre, E. Einarsen, H. Midtbo, S. Saeed, N. Pristaj, M. T. Lonnebakken, E. Gerdts
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2019)
Letter
Cardiac & Cardiovascular Systems
Mai Tone Lonnebakken, Ingeborg Eskerud
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Editorial Material
Public, Environmental & Occupational Health
Mai Tone Lonnebakken
JOURNAL OF WOMENS HEALTH
(2020)
Editorial Material
Medicine, General & Internal
Mai Tone Lonnebakken
Review
Cardiac & Cardiovascular Systems
Ute Seeland, Janos Nemcsik, Mai Tone Lonnebakken, Karolina Kublickiene, Helena Schluchter, Chloe Park, Giacomo Pucci, Ioana Mozos, Rosa-Maria Bruno
Summary: Sex and gender play important roles in cardiovascular system physiology, pathophysiology, and disease development, particularly in the progression of vascular ageing and its impact on cardiovascular, renal, and cerebrovascular diseases. Understanding sex differences in physiological ageing and disease-related changes in vascular ageing trajectories is crucial to avoid misdiagnosis and mistreatment. Gender roles also influence the effectiveness of cardiovascular preventive strategies and acceptance of diagnostic and therapeutic measures, with health behaviors and sociocultural norms contributing to premature arterial vascular ageing. The VascAgeNet Gender Expert Group aims to advance the incorporation of non-invasive vascular ageing measures in routine clinical practices by addressing sex and gender differences and seeking solutions.
HEART LUNG AND CIRCULATION
(2021)
Review
Cardiac & Cardiovascular Systems
Enxhela Sulo, Einar Skulstad Davidsen, Mai Tone Lonnebakken, Oyvind Bleie, Sahrai Saeed
Summary: This study reported paradoxical sinus deceleration observed during dobutamine stress echocardiography in six patients and described its occurrence patterns and clinical characteristics. The deceleration mainly occurred at maximal dobutamine infusion, accompanied by a decrease in blood pressure and resolved spontaneously after cessation of dobutamine infusion. Patients experiencing paradoxical sinus deceleration commonly had abnormal left ventricle geometry but differed in terms of age, sex, and cardiometabolic risk factors.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)
Article
Peripheral Vascular Disease
Silje Kjellevold Storesund, Iman Karaji, Elin Strand, Asbjorn Svardal, Mai Tone Lonnebakken, Rolf Kristian Berge, Gard Frodahl Tveitevag Svingen, Ottar Kjell Nygard, Eva Ringdal Pedersen
Summary: This study explored the predictive role of carnitine metabolites in cardiovascular disease and all-cause mortality among patients with non-obstructive coronary artery disease. The results showed that serum levels of acetyl, octanoyl-, and palmitoylcarnitine were associated with CVD mortality. Higher levels of acetyl- and palmitoylcarnitine were also linked to increased risk of all-cause mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2022)
Article
Multidisciplinary Sciences
Caroline A. Berge, Ingeborg Eskerud, Elise B. Almeland, Terje H. Larsen, Eva R. Pedersen, Svein Rotevatn, Mai Tone Lonnebakken
Summary: This study aimed to investigate the association between hypertension and extensive non-obstructive coronary artery disease (CAD) in patients with symptomatic chronic coronary syndrome (CCS). The results showed that hypertension was associated with extensive non-obstructive CAD in CCS patients, independent of factors such as sex, age, smoking, diabetes, statin treatment, obesity, and calcium score.
Article
Cardiac & Cardiovascular Systems
Ingeborg Eskerud, Eva Gerdts, Terje H. Larsen, Judit Simon, Pal Maurovich-Horvat, Mai Tone Lonnebakken
Summary: The total coronary artery plaque burden assessed by CCTA is independently associated with myocardial ischemia in patients with non-obstructive CAD, suggesting that quantification of plaque burden may be beneficial for clinical management in this patient population.
IJC HEART & VASCULATURE
(2021)
Article
Cardiac & Cardiovascular Systems
Mai Tone Lonnebakken, Ingeborg Eskerud, Terje Hjalmar Larsen, Helga Bergljot Midtbo, Marina Victorovna Kokorina, Eva Gerdts