Review
Plant Sciences
Aliya Sheik, Kwanwoo Kim, Ganji Lakshmi Varaprasad, Hoomin Lee, Suheon Kim, Eunsu Kim, Jin-Yong Shin, Seo Yeong Oh, Yun Suk Huh
Summary: Astragalus membranaceus, as a traditional herb with a long history in cancer treatment, has attracted researchers' attention for its immunomodulatory effects and potential in alleviating cancer-related fatigue. Its natural phytoconstituents show high anti-cancer activity and have been studied in clinical trials for overcoming the toxic effects of chemotherapy drugs.
Article
Medicine, Research & Experimental
Sung Yeon Ham, Ji Hae Jun, Hye-Bin Kim, Jae-Kwang Shim, Gisong Lee, Young-Lan Kwak
Summary: This study investigated the activities of key regulators affecting erythropoiesis in a rat model of iron deficiency anemia with inflammation. The results showed that IV iron therapy exacerbated inflammation and oxidative stress and did not resolve anemia.
Article
Biochemistry & Molecular Biology
Juan Yu, Xiao-dan Dong, Jian-shuang Jiao, Hai-yu Ji, An-jun Liu
Summary: The Astragalus membranaceus polysaccharide (APS4) shows direct cytotoxicity on various cancer cells and has potential therapeutic effects on solid tumors. Through experiments on S180 tumor-bearing mice, it was found that APS4 can regulate the immune system, inhibit solid tumor growth, and promote apoptosis of tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Endocrinology & Metabolism
Sama Anvari, Yasith Samarasinghe, Nouf Alotaiby, Maria Tiboni, Mark Crowther, Aristithes G. Doumouras
Summary: Iron deficiency and iron deficiency anemia are common complications following bariatric surgery, with variable strategies for iron supplementation. Oral iron was effective in about half of the studies, while both oral and intravenous iron were used for treatment, with intravenous iron showing higher effectiveness. Further high-quality prospective trials are needed to determine the optimal dosage, route, and duration of iron supplementation after bariatric surgery.
Article
Biochemistry & Molecular Biology
Xue-Feng Bao, Pei-Hong Cao, Jin Zeng, Luo-Min Xiao, Zhi-Hui Luo, Jian Zou, Chuan-Xi Wang, Zhong-Xiang Zhao, Zheng-Qun Zhou, Hui Zhi, Hao Gao
Summary: Eleven unknown and three known pterocarpans were isolated and identified from Huang-qi, a traditional Chinese medicine. Among them, nine rare apiosyl-containing pterocarpan glycosides were discovered. These compounds exhibited hypoglycemic and antioxidant activities.
Review
Chemistry, Medicinal
Chun-Xiao Li, Ying Liu, Yu-Zhen Zhang, Jing-Chun Li, Jiang Lai
Summary: This review provides a comprehensive overview of the research progress on the immunomodulatory effect of Astragalus polysaccharide. It summarizes the effects of Astragalus polysaccharide on central and peripheral immune organs, as well as various immune cells. Astragalus polysaccharide shows promising potential for the treatment of diseases, particularly in the field of cancer.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Ana M. Puga, Maria de Lourdes Samaniego-Vaesken, Ana Montero-Bravo, Mar Ruperto, Teresa Partearroyo, Gregorio Varela-Moreiras
Summary: Gut microbiota plays a crucial role in human health, and both diet and iron supplementation have an impact on it. Iron supplementation can potentially harm the gut microbiota, therefore it should be used with caution and recommended only to individuals with confirmed iron deficiency or iron-deficiency anemia. Further population studies are needed to confirm these findings.
Article
Biochemistry & Molecular Biology
Zhili Sheng, Yueming Jiang, Junmei Liu, Bao Yang
Summary: Astragalus membranaceus is a valuable medicinal plant species widely distributed in Asia with its root being the main medicinal tissue rich in methoxylated flavonoids. The chemical composition and antioxidant activity of the plant can be influenced by its origin, as shown through UHPLC-MS/MS analysis of extracts from four different origins. The study identified key compounds that can differentiate A. membranaceus from different regions and found that extracts from Inner Mongolia exhibited the highest antioxidant activity.
Article
Plant Sciences
Shuai Tang, Wei Liu, Qianqian Zhao, Kaidong Li, Jingyi Zhu, Wenbing Yao, Xiangdong Gao
Summary: The study found that co-administration of total polysaccharides from Astragalus membranaceus and Codonopsis pilosula could improve clinical symptoms, restore immune balance, and alleviate colonic mucosal damage in colitis mice. The unique efficacy of co-administration depended on the activation of the aryl hydrocarbon receptor (AhR) and upregulation of isovaleric acid and butyrate at specific doses.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Guillermo Bastida, Claudia Herrera-de Guise, Alicia Algaba, Yolanda Ber Nieto, Jose Manuel Soares, Virginia Robles, Fernando Bermejo, Esteban Saez-Gonzalez, Fernando Gomollon, Pilar Nos
Summary: This study showed that sucrosomial iron (SI) treatment is effective and well-tolerated for patients with iron deficiency anemia (IDA) and inflammatory bowel disease (IBD) who are intolerant to oral iron salts. It significantly increased hemoglobin levels and improved quality of life for patients.
Article
Pediatrics
Mingyan Li, Ying Lv, Jionghuan Ying, Lin Xu, Weijun Chen, Quan Zheng, Chai Ji, Jie Shao
Summary: The study found that a daily dose of 2 mg/kg iron supplement is effective in maintaining iron homeostasis in preterm infants, and factors such as Hb levels at birth and at 3 months, gender, and feeding patterns can affect the prevalence of iron deficiency and iron deficiency anemia.
FRONTIERS IN PEDIATRICS
(2021)
Review
Medicine, General & Internal
Shira Buchrits, Oranit Itzhaki, Tomer Avni, Pia Raanani, Anat Gafter-Gvili
Summary: Intravenous iron can effectively decrease the need for blood transfusions in patients with chemotherapy-induced anemia without increasing the risk of adverse events. The use of intravenous iron should be considered in the treatment of chemotherapy-induced anemia in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Carolina Thalya da Silva Paulino, Marislei Nishijima, Flavia Mori Sarti
Summary: Anemia prevalence among children under five in Brazil is high, with government iron supplementation programs showing significant effects on reducing hospitalizations and lengths of stay due to iron-deficiency anemia, especially in non-poor areas. The programs complement each other but do not influence mortality rates, indicating a need for operational improvements to achieve better outcomes in reducing severe iron-deficiency anemia among children under four.
Article
Nutrition & Dietetics
Ajibola Ibraheem Abioye, Michael D. Hughes, Christopher R. Sudfeld, Zulfiqarali Premji, Said Aboud, Davidson H. Hamer, Drucilla J. Roberts, Christopher P. Duggan, Wafaie W. Fawzi
Summary: The impact of iron deficiency anemia (IDA) and non-iron deficiency anemia (NIDA) on pregnancy and newborn outcomes, as well as the effectiveness of iron supplementation, remains uncertain. This study found that iron supplementation is effective even among pregnant women with NIDA.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Surgery
Chris Triphaus, Leonie Judd, Patricia Glaser, Marie H. Goehring, Elke Schmitt, Sabine Westphal, Christoph Fuellenbach, Simone Lindau, Kai Zacharowski, Patrick Meybohm, Suma Choorapoikayil
Summary: The study demonstrated that administering intravenous iron within 7 days before surgery effectively increased hemoglobin levels, reduced intraoperative transfusion rates, and shortened hospital stays for surgical patients with iron deficiency anemia.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)