Article
Biochemistry & Molecular Biology
Fengwei Luo, Weikang Guo, Wenhu Liu
Summary: This study found that bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exo) inhibit vascular calcification (VC) and osteogenic transdifferentiation by transferring miR-15a/15b/16 and inhibiting their common target gene NFATc3, which down-regulates osteocalcin (OCN) expression and thus inhibits HA-VSMC osteogenic transdifferentiation. This study identifies a novel target for therapeutic therapy of CKD-VC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Wenqian Wei, Xiaodong Guo, Lijie Gu, Jieshuang Jia, Man Yang, Weijie Yuan, Shu Rong
Summary: The study discovered that bone marrow mesenchymal stem cell-derived exosomes inhibit high phosphate-induced vascular calcification and improve renal function in chronic kidney disease through the SIRT6-HMGB1 deacetylation pathway.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Mehrdad Hajinejad, Sajad Sahab-Negah
Summary: Neuroinflammation plays a crucial role in neurological disorders, and mesenchymal stem cells can modulate inflammation and microglia/macrophage polarization through exosome secretion. Studies have shown that miRNAs contained in exosomes have the potential to impact recipient cell behavior, providing a novel therapeutic approach for addressing inflammatory pathways in neurological diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ying Zhang, Xiangyang Cao, Peifeng Li, Yanan Fan, Leilei Zhang, Xianghao Ma, Ruibo Sun, Youwen Liu, Wuyin Li
Summary: The study demonstrates that BMSC-exo carrying miR-935 promotes osteoblast proliferation and differentiation through targeting STAT1.
Article
Orthopedics
Tengjing Xu, Yunting Lin, Xinning Yu, Guangyao Jiang, Jiajie Wang, Kaiwang Xu, Jinghua Fang, Siheng Wang, Xuesong Dai
Summary: This study compared the effects of adipose stem cell-derived exosomes and ectosomes on Achilles tendinopathy. The results showed that ASC-Exos had more beneficial effects on tendon repair than ASC-Ectos.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Cell Biology
Lei Zhang, Pengrong Ouyang, Gaole He, Xiaowei Wang, Defu Song, Yijun Yang, Xijing He
Summary: The study suggests that utilizing exosomes derived from BMMSCs overexpressing miR-126 for treatment can enhance proliferation, migration, and angiogenesis of endothelial cells, as well as accelerate wound healing.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Yinghui Wang, Jiaxi Liu, Honggang Wang, Shasha Lv, Qingzhen Liu, Shan Li, Xue Yang, Gang Liu
Summary: Diabetic kidney disease (DKD) is a major cause of end-stage renal disease worldwide. Exosomes derived from human umbilical cord mesenchymal stem cells (HUC-MSCs) have shown effectiveness in treating DKD, but the mechanisms behind this are not well understood. This study investigated the link between DKD and inflammasome activation, and the therapeutic potential of exosomes in relieving inflammation and repairing damage. The results demonstrated that MSC-derived exosomes, particularly those containing miR-22-3p, protected against inflammation in podocytes and diabetic mice by mediating the NLRP3 inflammasome. This highlights the potential of MSC-derived exosomes as a cell-free therapeutic strategy for DKD.
Review
Medicine, General & Internal
Huan Zhao, Haojie Liu, Yueming Liu, Juan Jin, Qiang He, Bo Lin
Summary: This paper reviews the mechanism of the role of extracellular vesicles (EVs), especially exosomes, in vascular calcification (VC) in patients with chronic kidney disease (CKD), and discusses the potential application of related therapeutic targets in the clinical setting.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Physical
Chunhui Sheng, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Hao Liu, Xiao Zhang, Ping Zhang, Yunsong Liu, Wenyue Li, Yongsheng Zhou, Longwei Lv
Summary: This study investigated the potential of exosomes derived from human adipose-derived stem cells (hASCs) in promoting osteogenic differentiation for osteoporosis treatment. The study identified the key differentially expressed microRNA between two exosomes and their potential target gene. Results showed that exosomes from osteogenic induction medium had a better effect on promoting osteogenic differentiation than those from proliferation medium. Moreover, miR-335-3p inhibitor-optimized exosomes enhanced osteogenic differentiation in vitro and bone density in vivo, suggesting the potential of engineered exosomes in optimizing exosome-based therapy for osteoporosis.
Review
Peripheral Vascular Disease
Alfonso Eirin, Lilach O. Lerman
Summary: MSC-derived extracellular vesicles (EVs) have the potential to modulate pathways responsible for renal injury, including inflammation, oxidative stress, apoptosis, fibrosis, and microvascular remodeling, leading to renoprotective effects in experimental studies. However, scarce clinical data and challenges such as standardization of methods for EV isolation and characterization, EV fate, duration of EV effects, and effects of cardiovascular risk factors need to be addressed for successful clinical translation.
Article
Chemistry, Multidisciplinary
Xue-Han Xu, Tie-Jun Yuan, Haseeb Anwar Dad, Mu-Yang Shi, Yi-Yu Huang, Zhi-Hong Jiang, Li-Hua Peng
Summary: Exosomes derived from ginseng were shown to efficiently promote neural differentiation of BMSCs by transferring miRNAs, demonstrating potential for neural regenerative medicine both in vitro and in vivo.
Article
Cell & Tissue Engineering
Jingqiong Xun, Chan Li, Meilu Liu, Yueming Mei, Qiongfei Zhou, Bo Wu, Fen Xie, Yuling Liu, Ruchun Dai
Summary: The study found that bone microdamage increased in aged osteoporotic rats after fatigue loading, and the osteogenic differentiation ability of bone mesenchymal stem cells decreased. However, treatment with serum exosomes from young rats highly expressing miRNA-19b-3p was able to improve this decreased osteogenic differentiation ability.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Medicine, General & Internal
Fernanda G. Rodrigues, Milene S. Ormanji, Ita P. Heilberg, Stephan J. L. Bakker, Martin H. de Borst
Summary: This article explores the deregulation of gut microbiota in patients with chronic kidney disease (CKD) and its impact on vascular and bone diseases. It discusses the influence of diet, medications, and other factors on gut microbiota composition and subsequently on the overall health of CKD patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xinhai Lin, Haodong Wang, Tiantian Wu, Yaqin Zhu, Long Jiang
Summary: These findings suggest that exosomal miR-126 derived from SCAPs under hypoxia can enhance HUVEC angiogenesis by suppressing SPRED1 and activating the ERK signaling pathway.
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
