期刊
NANO LETTERS
卷 21, 期 19, 页码 8151-8159出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c02530
关键词
plant-derived exosomes; microRNA transfer; nanoplatform; mesenchymal stem cells; neural differentiation
类别
资金
- National Key Research and Development Program of China [2018YFC1105404]
- National Natural Science Foundation of China [81473145]
- Key Project at Central Government Level: The ability establishment of sustainable use for valuable Chinese medicine resources [2060302]
- Macau Science and Technology Development Fund, Macau Special Administrative Region, China
Exosomes derived from ginseng were shown to efficiently promote neural differentiation of BMSCs by transferring miRNAs, demonstrating potential for neural regenerative medicine both in vitro and in vivo.
Differentiation of bone marrow derived mesenchymal stem cells (BMSCs) into functional neural cells has been widely investigated for treating neural diseases. However, the limited neural differentiation of BMSCs remains a big challenge to overcome. Herein, for the first time, ginseng-derived exosomes (G-Exos) were demonstrated to have excellent efficiency in stimulating the neural differentiation of BMSCs by transferring the incorporated miRNAs to BMSCs efficiently. In vivo, a photo-cross-linkable hydrogel with chemokine and G-Exos loaded shows strong efficacy in recruiting and directing the neural differentiation of BMSCs in the program. G-Exos were demonstrated to be promising nanoplatforms in transferring plant-derived miRNAs to mammalian stem cells for neural differentiation both in vitro and in vivo, possessing great potential in neural regenerative medicine.
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