Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes

Mitochondrial activity in different regions of the brain at the onset of streptozotocin-induced diabetes in rats

(2018) Ixchel Osorio-Paz et al.   MOLECULAR BIOLOGY REPORTS

Intermittent metabolic switching, neuroplasticity and brain health

(2018) Mark P. Mattson et al.   NATURE REVIEWS NEUROSCIENCE

Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes

(2018) Mary E. Lacy et al.   DIABETES CARE

Altered mitochondrial function in insulin-deficient and insulin-resistant states

(2018) Gregory N. Ruegsegger et al.   JOURNAL OF CLINICAL INVESTIGATION

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

(2017) Na Zhao et al.   NEURON

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology

(2017) Maud Gratuze et al.   Scientific Reports

Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation and microglial activation in a streptozotocin-induced Alzheimer’s rat model

(2017) Zhangyu Guo et al.   Scientific Reports

Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers

(2016) Daniel S. Lark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

(2016) Stephanie Kullmann et al.   PHYSIOLOGICAL REVIEWS

Structural and activity characterization of human PHPT1 after oxidative modification

(2016) Daniel R. Martin et al.   Scientific Reports

Altered Skeletal Muscle Mitochondrial Proteome As the Basis of Disruption of Mitochondrial Function in Diabetic Mice

(2015) Piotr Zabielski et al.   DIABETES

Drp1-Mediated Mitochondrial Abnormalities Link to Synaptic Injury in Diabetes Model

(2014) Shengbin Huang et al.   DIABETES

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

High Insulin Combined With Essential Amino Acids Stimulates Skeletal Muscle Mitochondrial Protein Synthesis While Decreasing Insulin Sensitivity in Healthy Humans

(2014) Matthew M. Robinson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The ceramide system as a novel antidepressant target

(2014) Johannes Kornhuber et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice

(2013) Piotr Zabielski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Tissue cholesterol content alterations in streptozotocin-induced diabetic rats

(2012) Xin-ting Wang et al.   ACTA PHARMACOLOGICA SINICA

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis

(2012) Ian R. Lanza et al.   Cell Metabolism

A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans

(2012) Agnieszka U. Blachnio-Zabielska et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Topiramate Treatment Protects Blood-Brain Barrier Pericytes from Hyperglycemia-Induced Oxidative Damage in Diabetic Mice

(2011) Tulin O. Price et al.   ENDOCRINOLOGY

Accurate Determination of the Oxidative Phosphorylation Affinity for ADP in Isolated Mitochondria

(2011) Gilles Gouspillou et al.   PLoS One

Regulation of Cholesterol and Fatty Acid Synthesis

(2011) J. Ye et al.   Cold Spring Harbor Perspectives in Biology

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia

(2010) Susana Cardoso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism

(2010) Ryo Suzuki et al.   Cell Metabolism

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death

(2009) Arundhati Jana et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

Impaired Regulation of Brain Mitochondria by Extramitochondrial Ca2+in Transgenic Huntington Disease Rats

(2008) Frank N. Gellerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

(2003) J. David Sweatt   JOURNAL OF NEUROCHEMISTRY