There is blood in the water: hemolysis, hemoglobin, and heme in acute lung injury

Cell-free hemoglobin: a novel mediator of acute lung injury

(2016) Ciara M. Shaver et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells

(2016) Narendranath Reddy Chintagari et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung Injury

(2016) Saurabh Aggarwal et al.   ANTIOXIDANTS & REDOX SIGNALING

Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices

(2016) Joo-Yeun Oh et al.   Redox Biology

Vasculopathy and pulmonary hypertension in sickle cell disease

(2015) Karin P. Potoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

(2015) S. M. Camus et al.   BLOOD

Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration

(2015) David C. Irwin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma–hemorrhage

(2015) Ryan Stapley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Compartmentalized nitric oxide signaling in the resistance vasculature

(2015) Stephanie M. Mutchler et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The matrikine N- -PGP couples extracellular matrix fragmentation to endothelial permeability

(2015) C. S. Hahn et al.   Science Advances

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

(2014) G. Chen et al.   BLOOD

Elevation of Plasma Cell-Free Hemoglobin in Pulmonary Arterial Hypertension

(2014) Evan L. Brittain et al.   CHEST

Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

(2014) Dominik J. Schaer et al.   Frontiers in Physiology

Thinking outside the cell: how cell-free hemoglobin can potentiate acute lung injury

(2013) Julie A. Bastarache et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Methemoglobin-induced signaling and chemokine responses in human alveolar epithelial cells

(2013) Sharon Mumby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

Association Between Cell-Free Hemoglobin, Acetaminophen, and Mortality in Patients With Sepsis

(2013) David R. Janz et al.   CRITICAL CARE MEDICINE

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism

(2012) Paul W. Buehler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia

(2012) S. B. Solomon et al.   BLOOD

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

Stored red blood cell transfusions: Iron, inflammation, immunity, and infection

(2012) E.A. Hod et al.   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

(2011) Chenell Donadee et al.   CIRCULATION

Hemodialysis-Induced Release of Hemoglobin Limits Nitric Oxide Bioavailability and Impairs Vascular Function

(2010) Christian Meyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction1

(2009) Cilina Rodriguez et al.   BIOCHEMICAL JOURNAL

Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation

(2008) N. S. Mangalmurti et al.   BLOOD