Review
Biochemistry & Molecular Biology
Francesco Liguori, Elisa Mascolo, Fiammetta Verni
Summary: Diabetes mellitus is a heterogeneous disease characterized by high blood sugar caused by a combination of genetic and environmental factors, with both monogenic and multigenic forms. While many putative causative genes have been identified, a large percentage of cases remain undiagnosed, indicating a need for further research to identify causal variants of diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Yanan Wang, Qing Liu, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: Research indicates that cAMP plays a crucial role in metabolism and glucose homeostasis in various organs, while bioactive compounds in diet can influence diabetes pathogenesis by targeting cAMP signaling pathway.
Review
Biochemistry & Molecular Biology
Anna Fosch, Sebastian Zagmutt, Nuria Casals, Rosalia Rodriguez-Rodriguez
Summary: SF1 neurons in the ventromedial hypothalamus play a crucial role in sensing glucose levels and mediating insulin and leptin signaling, as well as in energy expenditure and glucose homeostasis, particularly in the early stages of obesity. While studies have provided insight into the central role of these neurons in whole-body energy homeostasis, they have also raised new questions regarding the existence of neuronal sub-populations and the complexity of neurocircuitry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Xiaohui Pan, Shibing Tao, Nanwei Tong
Summary: Neurotransmitters play a vital role in regulating glucose homeostasis in pancreatic islets, and dysfunction of neurotransmitter receptors is associated with the development of type 2 diabetes. Targeting different transmitter systems holds great potential in preventing and treating type 2 diabetes and other metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Peng Ju Liu, Yanping Liu, Liangkun Ma, Lihong Liu, Ting Hu, Zhuoling An, Ai Min Yao, Liang Yu Xia
Summary: The study found that plasma taurine level may be associated with the risk of gestational diabetes mellitus development, especially in multiparous women.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Josephine H. Li, Lukasz Szczerbinski, Adem Y. Dawed, Varinderpal Kaur, Jennifer N. Todd, Ewan R. Pearson, Jose C. Florez
Summary: Individuals with a higher genetic burden for T2D experience a greater acute and sustained response to sulfonylureas, suggesting potential for targeted pharmacologic intervention.
Article
Endocrinology & Metabolism
Leticia Maria de Souza Cordeiro, Lauren Bainbridge, Nagavardhini Devisetty, David H. McDougal, Dorien J. M. Peters, Kavaljit H. Chhabra
Summary: This study found that knocking out Glut2 in the kidneys can reverse hyperglycemia and normalize body weight in mouse models of diabetes and obesity. The results also revealed a novel crosstalk between renal GLUT2 and SGLT2 in regulating systemic glucose homeostasis.
Article
Endocrinology & Metabolism
Jiao Wang, Adrian I. Campos, Luis M. Garcia-Marin, Miguel E. Renteria, Lin Xu
Summary: This study used multiple genetic methods to investigate the causal associations between sleep apnea and snoring with type 2 diabetes, taking into account the role of BMI. The results showed that the associations between sleep apnea and snoring with type 2 diabetes were mainly driven by BMI. BMI accounted for a significant portion of the total effect of sleep apnea and snoring on type 2 diabetes.
Article
Environmental Sciences
Liyi Zhang, Pengpeng Wang, Yuhan Zhou, Yukai Cheng, Jialin Li, Xirong Xiao, Chuanmin Yin, Jiufeng Li, Xia Meng, Yunhui Zhang
Summary: This study found that gestational exposure to ozone is associated with an increased risk of gestational diabetes mellitus (GDM) and disrupted glucose homeostasis in pregnant women. There is a concentration-response relationship, and the critical window for the effects of ozone exposure on GDM development is identified as weeks 5-10 of gestation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Ram Prasad, Jason L. Floyd, Mariana Dupont, Angela Harbour, Yvonne Adu-Agyeiwaah, Bright Asare-Bediako, Dibyendu Chakraborty, Kara Kichler, Aayush Rohella, Sergio Li Calzi, Regina Lammendella, Justin Wright, Michael E. Boulton, Gavin Y. Oudit, Mohan K. Raizada, Bruce R. Stevens, Qiuhong Li, Maria B. Grant
Summary: The components of the systemic and intestinal renin-angiotensin system have been found to be associated with gut barrier permeability, glucose homeostasis, systemic inflammation, and the progression of diabetic retinopathy. Changes in gut-regulated components of the immune system, gut leakage markers, and angiotensin II were observed in T1D patients and mice, and were assessed for relevance.
CIRCULATION RESEARCH
(2023)
Review
Nutrition & Dietetics
Wanbao Yang, Wen Jiang, Shaodong Guo
Summary: This article reviews the effects of different components of macronutrients on insulin sensitivity and their underlying mechanisms, highlighting the importance of adjusting the intake of beneficial food compounds for the prevention of insulin resistance and type 2 diabetes.
Article
Environmental Sciences
Ruyi Liang, Linling Yu, Wei Liu, Chaoqian Dong, Qiyou Tan, Mengyi Wang, Zi Ye, Yongfang Zhang, Minjing Li, Bin Wang, Xiaobing Feng, Min Zhou, Weihong Chen
Summary: This study investigated the effects of pyrethroid bifenthrin on glucose homeostasis and the risk of type 2 diabetes. The results showed that bifenthrin exposure was dose-dependently associated with glucose dysregulation, with plasma protein carbonyl mediation. Future studies should consider the simultaneous exposure of pyrethroids with other pollutants.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Yacong Bo, Yongjian Zhu
Summary: This study found that the OPEs compound DMTP might be associated with impaired glucose homeostasis and may increase the prevalence of T2D in U.S. adults.
Review
Pharmacology & Pharmacy
Khaled Benchoula, Aditya Arya, Ishwar S. Parhar, Wong Eng Hwa
Summary: This review discusses the importance of maintaining balanced glucose homeostasis in preventing or treating diabetes and obesity, as well as the complexity of activating and inhibiting glucose production. It focuses on the key role of FoxO1 in obesity-induced insulin susceptibility and provides potential therapeutic approaches.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Qiyou Tan, Shijie Yang, Bin Wang, Mengyi Wang, Linling Yu, Ruyi Liang, Wei Liu, Jiahao Song, Yanjun Guo, Min Zhou, Weihong Chen
Summary: This study investigates the longitudinal relationships between PCB exposure and glucose homeostasis and T2D risk in the Chinese population. The study also examines the interactions between PCB exposure, genetic susceptibility, and lifestyle. The findings suggest that PCB-118 exposure is positively associated with FPG, FPI, insulin resistance, and incident T2D risk. Additionally, the T2D polygenic risk score is positively associated with FPG and incident T2D risk. Individuals with a high T2D-PRS and high PCB-118 have significantly increased FPG and T2D risk.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Editorial Material
Gastroenterology & Hepatology
Patrice D. Cani, Claude Knauf
Review
Endocrinology & Metabolism
Matthias Van Hul, Patrice D. Cani
Summary: This Review summarizes the evidence that the gut microbiota plays a role in regulating body weight homeostasis. It discusses the opportunities, limitations, and challenges of using gut microbiota-related approaches to achieve and maintain a healthy body weight in overweight or obese individuals. The complex hormonal, neural, and metabolic mechanisms that regulate energy intake and expenditure, and therefore body weight, are influenced by environmental factors and internal responses. Additionally, the microorganisms in the gut microbiota have direct effects on food digestion, absorption, and metabolism, as well as various protective, structural, and metabolic effects on the intestines and peripheral tissues, which further impact body weight. This Review outlines the historical and recent advances in understanding the involvement of the gut microbiota in regulating body weight homeostasis and discusses the opportunities, limitations, and challenges of using gut microbiota-related approaches for maintaining a healthy body weight.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Cell Biology
Francesco Suriano, Claudia Manca, Nicolas Flamand, Matthias Van Hul, Nathalie M. Delzenne, Cristoforo Silvestri, Patrice D. Cani, Vincenzo Di Marzo
Summary: This study characterized the profile of endocannabinoidome and oxylipins in the intestines of obese and diabetic mice, and found correlations between these mediators and intestinal inflammation and gut microbiota composition. The results suggest that the altered eCBome and oxylipin signaling may contribute to obesity and diabetes-induced gut dysbiosis and inflammation.
Article
Chemistry, Multidisciplinary
Ines Domingues, Cecilia Bohns Michalowski, Valentina Marotti, Wunan Zhang, Matthias Van Hul, Patrice D. Cani, Isabelle A. Leclercq, Ana Beloqui
Summary: Non-alcoholic fatty liver disease (NAFLD) affects a significant portion of the adult population worldwide and no approved pharmacologic therapy is currently available. A novel drug delivery system called lipid nanocapsules (LNCs) has shown promise in treating NAFLD by inducing the secretion of glucagon-like peptide 1 (GLP-1). This study aimed to compare the efficacy of the LNCs system with subcutaneous injection of a GLP-1 analog in two mouse models of NAFLD. The results demonstrated that chronic administration of the LNCs system improved glucose homeostasis and insulin resistance, and prevented disease progression to a greater extent than subcutaneous injection in both models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Microbiology
Alice de Wouters d'Oplinter, Marko Verce, Sabrina J. P. Huwart, Jacob Lessard-Lord, Clara Depommier, Matthias Van Hul, Yves Desjardins, Patrice D. Cani, Amandine Everard
Summary: Excessive hedonic consumption contributes to weight gain, and identifying its causes can help tackle obesity. The gut microbiome, which is altered during obesity, regulates food intake and influences reward-related brain areas. Through metabolomic analysis, 3-(3'-hydroxyphenyl)propanoic acid (33HPP) was found to be highly correlated with motivation. Administering 33HPP in mice revealed its effects on food reward.
Article
Gastroenterology & Hepatology
Marion Regnier, Matthias Van Hul, Martin Roumain, Adrien Paquot, Alice de Wouters d'Oplinter, Francesco Suriano, Amandine Everard, Nathalie M. Delzenne, Giulio G. Muccioli, Patrice D. Cani
Summary: Consumption of prebiotics and plant-based compounds can have beneficial effects on health by modulating gut microbiota composition, making them a promising nutritional strategy for metabolic diseases. In this study, we investigated the effects of inulin and rhubarb, both separately and combined, on diet-induced metabolic disease in mice. We found that supplementation with both inulin and rhubarb prevented weight and fat gain, as well as other obesity-related metabolic disorders. This was accompanied by increased energy expenditure, reduced whitening of brown adipose tissue, improved mitochondrial activity, and increased expression of lipolytic markers in white adipose tissue.
Article
Endocrinology & Metabolism
Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Torma Ferenc, Michael Orthofer, Rebecca Yarwood, Leonhard X. Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J. F. Cronin, Maria Novatchkova, Anoop Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Eric Rullman, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S. Chamberlain, Marica Bakovic, Siddharth Banka, Josef M. Penninger
Summary: Muscle degeneration is a common cause of frailty and dependency in inherited diseases and ageing. The enzyme PCYT2/ECT plays a critical role in muscle health. Deficiency in PCYT2 leads to severe disease and muscle weakness. Mechanistically, PCYT2 deficiency affects cellular bioenergetics and membrane lipid bilayer structure. PCYT2 activity declines in ageing muscles and therapeutic delivery of PCYT2 improves muscle weakness.
Article
Biochemistry & Molecular Biology
Justine Lallement, Ilyes Raho, Gregory Merlen, Dominique Rainteau, Mikael Croyal, Melody Schiffano, Nadim Kassis, Isabelle Doignon, Maud Soty, Floriane Lachkar, Michel Krempf, Matthias Van Hul, Patrice D. Cani, Fabienne Foufelle, Chloe Amouyal, Herve Le Stunff, Christophe Magnan, Thierry Tordjmann, Celine Cruciani-Guglielmacci
Summary: This study aimed to determine the role of de novo hepatic ceramide synthesis in energy and liver homeostasis. The results showed that mice lacking the Sptlc2 gene were protected against obesity induced by high fat diet and displayed a defect in lipid absorption. In addition, the deficiency enhanced glucose tolerance and attenuated hepatic glucose production, while the latter effect was dampened in presence of nSMase2 inhibitor. Furthermore, Sptlc2 disruption promoted apoptosis, inflammation, and progressive development of hepatic fibrosis. These findings highlight the importance of ceramides in liver homeostasis and metabolic functions.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Biochemistry & Molecular Biology
Emilie Moens de Hase, Camille Petitfils, Mireille Alhouayek, Clara Depommier, Pauline Le Faouder, Nathalie M. Delzenne, Matthias Van Hul, Giulio G. Muccioli, Nicolas Cenac, Patrice D. Cani
Summary: The newly identified bacterium D. welbionis J115(T) improves host metabolism in high-fat diet-fed mice through the production of bioactive lipids. These metabolic effects are associated with a whitening of brown adipose tissue and upregulation of genes related to PPAR-γ agonists.
JOURNAL OF LIPID RESEARCH
(2023)
Review
Neurosciences
Mukhamad Sunardi, Carla Cirillo
Summary: In the body, nerve tissue is found in both the central and peripheral nervous systems. The enteric nervous system (ENS) is a highly organized network of neurons and glial cells that form interconnected ganglia. Glial cells in the ENS have neurotrophic roles and retain neurogenic potential. Understanding the molecular basis of glia-derived neurogenesis may have important implications for biological and clinical purposes. This review discusses the potential use of gene-editing and cell transplantation as therapies for enteric neuropathies, focusing on the role of glial cells in nerve tissue repair.
NEUROSCIENCE LETTERS
(2023)
Article
Nutrition & Dietetics
Lionel Carneiro, Lucie Marousez, Matthias Van Hul, Lea Chantal Tran, Marie De Lamballerie, Delphine Ley, Patrice D. Cani, Claude Knauf, Jean Lesage
Summary: This study demonstrates that high hydrostatic pressure processing can reinforce intestinal barrier integrity without affecting gut microbiota composition and short chain fatty acid production.
Article
Multidisciplinary Sciences
Anne Abot, Amandine Brochot, Nicolas Pomie, Gwendoline Astre, Celine Druart, Willem M. de Vos, Claude Knauf, Patrice D. Cani
Summary: The use of pasteurized Akkermansia muciniphila has shown positive effects on metabolic parameters in obese mice, such as insulin, glycemia, and glucose tolerance, possibly through gut-brain axis signaling.
Correction
Public, Environmental & Occupational Health
Patrice Cani, Peter Clarys, Antoine Clinquart, Stefaan De Henauw, Nathalie Delzenne, Peter Deriemaeker, Caroline Douny, Isabelle Guelinckx, Inge Huybrechts, Lieven Huybregts, Patrick Kolsteren, Carl Lachat, Isabelle Laquiere, Yvan Larondelle, Jef Leroy, Guy Manghuin-Rogister, Christophe Matthys, Patrick Mullie, Jean Neve, Marie-Louise Scippo, Isabelle Sioen, Anne-Marie Remaut, John Van Camp, Stefanie Vandevijvere, Margareta Vansant
ARCHIVES OF PUBLIC HEALTH
(2023)