Article
Agriculture, Dairy & Animal Science
Uffe Krogh, Helene Quesnel, Nathalie Le Floch, Aude Simongiovanni, Jaap van Milgen
Summary: The study integrated physiological and empirical knowledge to establish a dynamic model for quantifying parameters controlling mammary gland output in sows. By modifying and extending a cattle mammary gland model, the production process of milk in sow mammary glands during lactation was successfully simulated.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Immunology
Dilay Cansever, Ekaterina Petrova, Sinduya Krishnarajah, Caroline Mussak, Christina A. Welsh, Wiebke Mildenberger, Kevin Mulder, Victor Kreiner, Elsa Roussel, Sebastian A. Stifter, Myrto Andreadou, Pascale Zwicky, Nicole Puertas Jurado, Hubert Rehrauer, Ge Tan, Zhaoyuan Liu, Camille Bleriot, Francesca Ronchi, Andrew J. Macpherson, Florent Ginhoux, Giancarlo Natalucci, Burkhard Becher, Melanie Greter
Summary: Macrophages play a role in immune defense, organogenesis, and tissue homeostasis. During lactation, a unique population of macrophages called liMacs emerges in the mammary gland and milk, which is similar to macrophages found in human milk.
Article
Biochemistry & Molecular Biology
Lilia Sanchez, Jessica Epps, Steven Wall, Cole McQueen, Scott J. Pearson, Kelly Scribner, Elizabeth A. Wellberg, Erin D. Giles, Monique Rijnkels, Weston W. Porter
Summary: The functionally differentiated mammary gland adapts to extreme levels of stress by activating specific protective mechanisms. The breast tumor suppressor gene SIM2s is identified as a novel regulator of mitophagy, a key component of this stress response.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Food Science & Technology
Christopher J. Mayerl, Chloe E. Edmonds, Francois D. H. Gould, Rebecca Z. German
Summary: Research has shown that thickened fluids lead to substantial changes in tongue movements during sucking in infants, while pharyngeal transit time and movements of the hyoid and soft palate remain unaffected during swallowing. This suggests that sucking behaviors are more sensitive to sensory feedback associated with changes in milk viscosity compared to pharyngeal swallow reflexes.
JOURNAL OF TEXTURE STUDIES
(2021)
Article
Nutrition & Dietetics
Agata Witczak, Anna Pohorylo, Hassan Abdel-Gawad
Summary: The study assessed the safety of infants related to endocrine-disrupting organochlorine pesticides (OCP) in breast milk. It was found that certain dietary habits of pregnant mothers could affect the levels of OCP compounds in breast milk. The consumption of specific food products, such as pork, beef, poultry, eggs, and dairy, was linked to increased pesticide residues in breast milk.
Article
Pharmacology & Pharmacy
Hedvig Nordeng, Christine Wegler, Annika Lindqvist, Erik Melander, Mikaela Magnusson, Peggy Gandia, Alice Panchaud, Pawel Baranczewski, Olav Spigset
Summary: This study demonstrates that the transfer of cetirizine and levocetirizine into breast milk is low and compatible with breastfeeding.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Isabel Ten-Domenech, Mari Merce Cascant-Vilaplana, Victor Navarro-Esteve, Birgit Felderer, Alba Moreno-Gimenez, Ivan Rienda, Maria Gormaz, Marta Moreno-Torres, David Perez-Guaita, Guillermo Quintas, Julia Kuligowski
Summary: This preliminary study aimed to characterize the cellular metabolome of human milk over the course of lactation. Cells were isolated and characterized, and their metabolites were analyzed using mass spectrometry. The results showed significant variations in the cellular composition and phenotypic properties of human milk during lactation. This study provides a basis for future investigations on the metabolomic fraction of the cellular compartment of human milk.
Article
Immunology
Laura Dickinson, Stephen Walimbwa, Yashna Singh, Julian Kaboggoza, Kenneth Kintu, Mary Sihlangu, Julie-Anne Coombs, Thokozile R. Malaba, Josaphat Byamugisha, Henry Pertinez, Alieu Amara, Joshua Gini, Laura Else, Christie Heiberg, Eva Maria Hodel, Helen Reynolds, Landon Myer, Catriona Waitt, Saye Khoo, Mohammed Lamorde, Catherine Orrell
Summary: The study investigated dolutegravir pharmacokinetics in pregnant women with untreated HIV presenting in late pregnancy, showing the relationship between dolutegravir concentrations in maternal plasma, umbilical cord, and breast milk, as well as the duration of prophylaxis for infants post maternal dolutegravir cessation.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Wenting Dai, Robin White, Jianxin Liu, Hongyun Liu
Summary: The mammary gland undergoes remarkable changes during development and has the ability to remodel and regenerate during lactation. Multiple processes, including cell proliferation, differentiation, and metabolic changes, under the control of cellular and hormonal signaling pathways, are required for the flexibility of the mammary gland. Understanding the subcellular events within mammary epithelial cells and how they relate to milk production and secretion provides insights into maintaining mammary/breast health.
PROGRESS IN LIPID RESEARCH
(2022)
Article
Nursing
Katherine R. Standish, Ginny Combs, Marcy Mcmahon, Cheryl Slater, Lisa Zani, Christina Pindar, Karol Serafin, Margaret G. Parker, Barbara L. Philipp
Summary: Late preterm infants have lower breastfeeding rates and there are few interventions or guidelines for managing them in non-intensive nursery settings. This study developed and implemented an interdisciplinary breastfeeding support program, which increased nurses' attentiveness and confidence in caring for late preterm infants. However, well-designed clinical studies are needed to identify effective breastfeeding support practices.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Nutrition & Dietetics
Dominick J. Lemas, Xinsong Du, Bethany Dado-Senn, Ke Xu, Amanda Dobrowolski, Marina Magalhaes, Juan J. Aristizabal-Henao, Bridget E. Young, Magda Francois, Lindsay A. Thompson, Leslie A. Parker, Josef Neu, Jimena Laporta, Biswapriya B. Misra, Ismael Wane, Samih Samaan, Timothy J. Garrett
Summary: This study aims to identify unique metabolites that may impact infant health outcomes by analyzing the metabolome of human and bovine milk at 2 weeks of life. The results showed that more than 80% of the milk metabolome is shared between human and bovine milk during early lactation. These findings highlight untargeted metabolomics as a potential strategy to identify unique and shared metabolites in bovine and human milk that may relate to and impact infant health outcomes.
Article
Medicine, Research & Experimental
Karen de Jong, David Damoiseaux, Dick Pluim, Hilde Rosing, Jos H. Beijnen, Hans van Thienen, Thomas P. C. Dorlo, Alwin D. R. Huitema, Frederic Amant
Summary: This study reports on the use of nivolumab during lactation in a woman with metastasized melanoma. It found that nivolumab accumulates in breast milk over two consecutive cycles. However, further research is needed to determine the safety of breastfeeding during nivolumab therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Multidisciplinary
Lina Zhang, Qiaran Lin, Jinyue Zhang, Yue Shi, Lina Pan, Yanmei Hou, Xiaoyu Peng, Wei Li, Jiaqi Wang, Peng Zhou
Summary: This study investigated the changes in oligosaccharides in human and animal milk over lactation. The results showed that human and camel milk had the highest number of common oligosaccharides, and certain oligosaccharides had higher concentrations in human milk compared to other animal species. Additionally, the changes of different oligosaccharides over lactation varied.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Qiu-Ye Lan, Si-Yu Huang, Chen-Yu Jiang, Meng-Tao Yang, Tong Wu, Xiao-Yan Chen, Zhao-Yan Liu, Wei Wei, Xing-Guo Wang, Hui-Lian Zhu
Summary: This study analyzed the molecular species of TAG in human milk fat and its changes during lactation using UPLC-Q-TOF-MS. The results showed that the changes in TAG mainly occurred in the early stages of lactation, and the TAG profile became stable after 200 days of lactation. Odd chain fatty acids may be important markers for identifying different lactation stages.
Article
Multidisciplinary Sciences
Alecia-Jane Twigger, Lisa K. Engelbrecht, Karsten Bach, Isabel Schultz-Pernice, Sara Pensa, Jack Stenning, Stefania Petricca, Christina H. Scheel, Walid T. Khaled
Summary: This study characterizes cells in human milk and identifies epithelial cells similar to luminal progenitors and immune cells. The findings contribute to understanding the remodelling of human mammary tissue during pregnancy and lactation, and provide insights into the interplay between pregnancy, lactation, and breast cancer.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Julie Hias, Lorenz Van der Linden, Karolien Walgraeve, Matthias Gijsen, Paola Mian, Birgit C. P. Koch, Karel Allegaert, Pieter Annaert, Jos Tournoy, Isabel Spriet
Summary: This study evaluated the pharmacokinetics of two oral paracetamol formulations in elderly patients aged 80 years and older. Results showed large interindividual differences in pharmacokinetic parameters of paracetamol in frail inpatients, with female sex and higher total serum bilirubin concentrations associated with paracetamol exposure.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Anne Smits, Pieter Annaert, Giacomo Cavallaro, Pieter A. J. G. De Cock, Saskia N. de Wildt, Jenny M. Kindblom, Florian B. Lagler, Carmen Moreno, Paula Pokorna, Michiel F. Schreuder, Joseph F. Standing, Mark A. Turner, Benedetto Vitiello, Wei Zhao, Annelie-Martina Weingberg, Raffaella Willmann, John van den Anker, Karel Allegaert
Summary: Developmental pharmacology focuses on the impact of maturation on drug metabolism and effects in pediatric patients, providing insights into drug development strategies and highlighting the importance of considering developmental pharmacodynamics. This paper summarizes current knowledge, identifies remaining gaps, and suggests innovative approaches for studying drug disposition and effects in children.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Elin Ngo, Olav Spigset, Angela Lupattelli, Alice Panchaud, Pieter Annaert, Karel Allegaert, Hedvig Nordeng
Summary: Current data on the use of antihistamines during breastfeeding and risks to the breastfed infants are insufficient, further human studies are needed; most product labels recommend avoiding the use of antihistamines during breastfeeding.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Infectious Diseases
Matthias Gijsen, Omar Elkayal, Pieter Annaert, Ruth Van Daele, Philippe Meersseman, Yves Debaveye, Joost Wauters, Erwin Dreesen, Isabel Spriet
Summary: This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of meropenem in critically ill patients with preserved or increased renal function. The results showed poor target attainment, with renal function being the only significant covariate.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Pharmacology & Pharmacy
Ruben Faelens, Nicolas Luyckx, Dirk Kuypers, Thomas Bouillon, Pieter Annaert
Summary: Before developing a precision dosing tool for tacrolimus, the tool's performance was evaluated through simulation. The results showed that the tool improved the probability of target attainment and dosing precision.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Caroline S. Foo, Rana Abdelnabi, Suzanne J. F. Kaptein, Xin Zhang, Sebastiaan ter Horst, Raf Mols, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Pieter Leyssen, Kai Dallmeier, Valentijn Vergote, Elisabeth Heylen, Laura Vangeel, Arnab K. Chatterjee, Pieter P. Annaert, Patrick F. Augustijns, Steven De Jonghe, Dirk Jochmans, Mieke Gouwy, Seppe Cambier, Jennifer Vandooren, Paul Proost, Christine van Laer, Birgit Weynand, Johan Neyts
Summary: Nelfinavir, an HIV protease inhibitor, shows antiviral activity against SARS-CoV-2 and can improve lung pathology induced by the virus in hamsters. It enhances the number and functionality of neutrophils and promotes their migration. Another combination of HIV protease inhibitors, Lopinavir/Ritonavir, also has a similar protective effect in this model.
ANTIVIRAL RESEARCH
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Nina Nauwelaerts, Thomas Bouillon, Neel Deferm, Bart Lammens, Pieter Annaert
Article
Biotechnology & Applied Microbiology
Lorenzo Nissen, Camilla Aniballi, Flavia Casciano, Alberto Elmi, Domenico Ventrella, Augusta Zannoni, Andrea Gianotti, Maria Laura Bacci
Summary: The first weeks of life are crucial for the microbial colonization of piglets' gastrointestinal tract. This study used an in vitro model to evaluate the impact of different concentrations of amoxicillin in milk on the piglets' colon microbiota. The results showed that amoxicillin had an influence on the microbiota and metabolites production, but did not alter the overall biodiversity. There was an increase in resistant species.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Oncology
Getahun Befirdu Abza, Jemal Hussien Ahmed, Abdu Adem Yesufe, Edom Seife, Mengistu Erkie, Isabel Spriet, Legese Chelkeba, Pieter Annaert
Summary: Hepatitis B virus (HBV) is an important risk factor for hepatocellular carcinoma (HCC). The clinical conditions and survival of patients with HCC in Ethiopia are poor. Patients who received antiviral therapy had better survival outcomes than those who did not. Therefore, it is crucial to increase vaccination coverage and access to antiviral drugs against hepatitis to reduce the devastation of HCC.
Article
Pharmacology & Pharmacy
Yeghig Armoudjian, Qi Lin, Bart Lammens, Johan Van Daele, Pieter Annaert
Summary: The IMI project ConcePTION was launched to fill the knowledge gap of using medicines during pregnancy and lactation. A high-throughput, robust, and reliable liquid chromatography tandem mass spectrometry method was developed and validated to determine the concentrations of amoxicillin in a large number of minipig plasma and milk samples.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2023)
Article
Pharmacology & Pharmacy
Julia Macente, Nina Nauwelaerts, Francesca M. Russo, Jan Deprest, Karel Allegaert, Bart Lammens, Rodolfo Hernandes Bonan, Jessica M. Turner, Sailesh Kumar, Andrea Diniz, Frederico S. Martins, Pieter Annaert
Summary: This study aims to use physiologically-based pharmacokinetic modeling to predict the maternal dose required for therapeutic fetal exposure in the treatment of congenital diaphragmatic hernia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Chiara Bernardini, Debora La Mantia, Roberta Salaroli, Domenico Ventrella, Alberto Elmi, Augusta Zannoni, Monica Forni
Summary: It has been demonstrated that blood vessels contain multipotent progenitor cells, including mesenchymal stem cells. In this study, a new improved method was described to isolate a pure population of vascular wall cells from the thoracic aorta of Gottingen Minipigs, while also collecting endothelial cells. The results showed that this new protocol allows for the isolation of a pure population of vascular wall mesenchymal stem cells (VW-MSCs) and endothelial cells, opening possibilities for in vitro vascular remodeling studies.
Article
Cardiac & Cardiovascular Systems
Anna Lorenzin, Luca Sgarabotto, Maria Laura Bacci, Alberto Elmi, Domenico Ventrella, Camilla Aniballi, Monica Zanella, Alessandra Brendolan, Luca Di Lullo, Claudio Ronco
Summary: This study presents a new miniaturized device called AD1 for extracorporeal ultrafiltration, designed for patients with fluid overload. The device operates at low pressure and flow regimes and has a user-friendly interface. The in vivo tests showed that it is safe, reliable, and accurate, opening up possibilities for clinical trials in various settings.
CARDIORENAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Karel Allegaert, Mohammad Yaseen Abbasi, Pieter Annaert, Olusola Olafuyi
Summary: The article introduces a structured approach, physiologically based pharmacokinetic (PBPK) modeling and simulation, to inform pharmacotherapy in preterm neonates. Through a systematic search, the authors collected information on the applications and optimization efforts of PBPK software packages in preterm neonates. It is suggested that collaboration between clinicians and modelers can help improve PBPK models despite existing knowledge gaps and uncertainties in their application.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Meeting Abstract
Developmental Biology
N. NAUWELAERTS, M. CEULEMANS, N. DEFERM, A. EERDEKENS, B. LAMMENS, Y. ARMOUDJIAN, K. VAN CALSTEREN, K. ALLEGAERT, L. DE VRIES, P. ANNAERT, A. SMITS
BIRTH DEFECTS RESEARCH
(2022)