Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis

(2016) Ri-Yao Yang et al.   PLoS One

TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy inDictyosteliumand human HeLa cells

(2015) Sandra Muñoz-Braceras et al.   Autophagy

Lipid Signalling Dynamics at the β-cell Plasma Membrane

(2015) Anne Wuttke   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Insulin response dysregulation explains abnormal fat storage and increased risk of diabetes mellitus type 2 in Cohen Syndrome

(2015) Floriane Limoge et al.   HUMAN MOLECULAR GENETICS

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

A Conserved Function in Phosphatidylinositol Metabolism for Mammalian Vps13 Family Proteins

(2015) Jae-Sook Park et al.   PLoS One

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

(2015) Martijn van de Bunt et al.   PLoS Genetics

Neural control of the endocrine pancreas

(2014) Rayner Rodriguez-Diaz et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

(2014) Christopher Benner et al.   BMC GENOMICS

Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression

(2014) Bas Brouwers et al.   Cell Metabolism

Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Glycaemic Traits

(2014) Letizia Marullo et al.   Current Diabetes Reports

Dorothy Hodgkin Lecture 2014Understanding genes identified by genome-wide association studies for Type 2 diabetes

(2014) G. A. Rutter   DIABETIC MEDICINE

SLC30A8 mutations in type 2 diabetes

(2014) Guy A. Rutter et al.   DIABETOLOGIA

Ins1 Cre knock-in mice for beta cell-specific gene recombination

(2014) Bernard Thorens et al.   DIABETOLOGIA

LKB1 and AMPK differentially regulate pancreatic β-cell identity

(2014) Marina Kone et al.   FASEB JOURNAL

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

(2014) Ryan K. Mitchell et al.   HUMAN MOLECULAR GENETICS

Cohen Syndrome-associated Protein COH1 Physically and Functionally Interacts with the Small GTPase RAB6 at the Golgi Complex and Directs Neurite Outgrowth

(2014) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Young capillary vessels rejuvenate aged pancreatic islets

(2014) Joana Almaça et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin

(2013) Nari Shiokawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chorein Sensitivity of Actin Polymerization, Cell Shape and Mechanical Stiffness of Vascular Endothelial Cells

(2013) Ioana Alesutan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SPO71 Encodes a Developmental Stage-Specific Partner for Vps13 in Saccharomyces cerevisiae

(2013) Jae-Sook Park et al.   EUKARYOTIC CELL

Joint Effect of Insulin Signaling Genes on Insulin Secretion and Glucose Homeostasis

(2013) Sabrina Prudente et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis

(2013) Michael N Weedon et al.   NATURE GENETICS

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

(2013) S. C. J. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells

(2012) Takehiro Hayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

(2012) G. da Silva Xavier et al.   DIABETOLOGIA

Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis

(2012) Michael Föller et al.   FASEB JOURNAL

Linking disease associations with regulatory information in the human genome

(2012) M. A. Schaub et al.   GENOME RESEARCH

VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae

(2012) Jae-Sook Park et al.   JOURNAL OF CELL SCIENCE

Novel pathogenic mutations and copy number variations in the VPS13A Gene in patients with chorea-acanthocytosis

(2011) Akiyuki Tomiyasu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

(2011) R. J. Strawbridge et al.   DIABETES

The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

(2011) N. Grarup et al.   DIABETOLOGIA

Vacuolar Protein Sorting Protein 13A, TtVPS13A, Localizes to the Tetrahymena thermophila Phagosome Membrane and Is Required for Efficient Phagocytosis

(2011) Haresha S. Samaranayake et al.   EUKARYOTIC CELL

Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity

(2011) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion

(2011) Jane T. McCluskey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children

(2011) Jan Windholz et al.   PLoS One

A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese

(2011) Bin Cui et al.   PLoS One

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

(2010) E. Ingelsson et al.   DIABETES

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

(2010) T. W. Boesgaard et al.   DIABETOLOGIA

Role of estrogen receptors alpha, beta and GPER1/GPR30 in pancreatic beta-cells

(2010) Angel Nadal   Frontiers in Bioscience-Landmark

Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated  -cells

(2010) A. Wuttke et al.   JOURNAL OF CELL SCIENCE

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

(2010) Toshimasa Yamauchi et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Insulin Gene Mutations Resulting in Early-Onset Diabetes: Marked Differences in Clinical Presentation, Metabolic Status, and Pathogenic Effect Through Endoplasmic Reticulum Retention

(2009) G. Meur et al.   DIABETES

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES