Review
Engineering, Biomedical
Eva Barcelona-Estaje, Matthew J. Dalby, Marco Cantini, Manuel Salmeron-Sanchez
Summary: This review emphasizes the importance of incorporating both cadherin and integrin ligands in biomaterial design to promote adhesive crosstalk. It introduces the structure and function of cadherins and their role in mechanotransduction, and discusses biomaterials mimicking cell-cell interactions and their applications in fundamental biology and tissue engineering.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Cell Biology
Sunitha Pulikkot, Liang Hu, Yunfeng Chen, Hao Sun, Zhichao Fan
Summary: This review article outlines the regulators of integrin activation in neutrophils, focusing on the critical regulators such as talin, RIAM, Rap1, and Kindlin, as well as newly discovered modulators involved in integrin activation.
Article
Biochemistry & Molecular Biology
Sonia Severin, Alessandra Consonni, Gaetan Chicanne, Sophie Allart, Bernard Payrastre, Marie-Pierre Gratacap
Summary: In this study, the role of SHIP1 in platelet activation was investigated. SHIP1 was found to regulate cytoskeletal organization and internal contractile activity in thrombin-activated platelets, and it interacted with the spectrin-based membrane skeleton. The absence of SHIP1 resulted in a loss of sustained association of integrins with the membrane skeleton and a decrease in α(IIb)β(3) integrin clustering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Mark Colasurdo, Elisa B. Nieves, Marc A. Fernandez-Yague, Christian Franck, Andres J. Garcia
Summary: Cell-extracellular matrix forces play a crucial role in regulating various physiological and pathological processes. However, the study of mechanobiology in three-dimensional systems is still limited. In this study, a platform integrating a synthetic hydrogel system with 3D traction force microscopy was developed to evaluate deformation and force responses within synthetic microenvironments. The findings shed light on the contributions of adhesive peptide density and polymer density, as well as matrix stiffness, to 3D force generation by fibroblasts. Rho-kinase-dependent contractility and vinculin expression were also found to be essential for significant 3D force generation. This research provides valuable insights into mechanobiology and how cells sense and transmit forces in three dimensions.
Review
Biochemistry & Molecular Biology
Jiang Liu, Junchao Zhang, Xun Fu, Shu Yang, Yan Li, Jianmin Liu, Michael E. DiSanto, Ping Chen, Xinhua Zhang
Summary: Benign prostatic hyperplasia (BPH) is a common disease in elderly men, characterized by prostatic enlargement and lower urinary tract symptoms (LUTs). Pathological processes of prostate hyperplasia are related to cell proliferation and apoptosis imbalance, inflammation, epithelial-mesenchymal transition (EMT) and growth factors. Cell adhesion molecules (CAMs), such as integrins and cadherins, play important roles in both physiological and pathological processes of BPH. Targeting CAMs may have potential therapeutic value for BPH treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Peng Zhang, Haojie Jiang, Mina Yang, Changlong Bi, Kandi Zhang, Dongsheng Liu, Meng Wei, Zheyi Jiang, Keyu Lv, Chao Fang, Junling Liu, Tiantian Zhang, Yanyan Xu, Junfeng Zhang
Summary: This study found that AGK deficiency or mutation significantly reduces platelet activation, including platelet aggregation, granules secretion, JON/A binding, spreading on Fg, and clot retraction. AGK also delays arterial thrombus formation. Mechanistically, AGK promotes Talin-1 Ser425 phosphorylation and affects the alpha IIb beta 3-mediated bidirectional signaling pathway to potentiate platelet activation and arterial thrombosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Maya Ezzo, Boris Hinz
Summary: The ability of cells to sense and respond to mechanical changes is crucial in tissue injury and fibrosis. Fibroblasts play a central role in tissue repair by regulating extracellular matrix secretion and organization. Dysregulated mechanotransduction can lead to fibrosis, and targeting the elements involved in fibroblast mechanotransduction may be a potential therapeutic approach.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Immunology
Stav Kozlovski, Ofer Regev, Anita Sapoznikov, Marina Kizner, Hagit Achdout, Ekaterina Petrovich-Kopitman, Jacob Elkahal, Yoseph Addadi, Fernanda Vargas E. Silva Castanheira, Sara W. Feigelson, Paul Kubes, Noam Erez, Natalio Garbi, Ronen Alon
Summary: In this study, the role of ICAM-1 and ICAM-2 in immune responses to influenza infection was investigated in mice. The results showed that lung capillary ICAMs were not essential for the entry of NK and neutrophils into virus-infected lungs. Additionally, ICAM-1 and ICAM-2 had little effect on the recruitment of naive T cells and B lymphocytes in mediastinal lymph nodes, but were critical for humoral immunity and the differentiation of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nicola Cirillo, Stephen S. Prime
Summary: The study investigated the role of MMPs and ADAM family proteases in pemphigus and pemphigoid diseases. Findings revealed that ADAM10 and MMP-9 activity is necessary for blister formation in experimental models of PV and BP. These molecules could be potential candidates for mechanism-based treatments of these blistering diseases.
Article
Biochemistry & Molecular Biology
Christopher J. Benwell, James A. G. E. Taylor, Stephen D. Robinson
Summary: NRP2 plays a crucial role in promoting EC adhesion and migration, contributing to vascular formation. Further research is needed to fully understand its specific functions in angiogenesis.
Article
Neurosciences
Samuel F. H. Barnett, Benjamin T. Goult
Summary: This study provides a new perspective on the understanding of biological digital information by analyzing the structure of MeshCODE in cells and proposing a possible gearbox mechanism for controlling synaptic transmission.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Kaitong Guo, Jing Zhang, Pei Huang, Yuqun Xu, Wenfei Pan, Kaiyue Li, Lu Chen, Li Luo, Weichun Yu, Shuai Chen, Sicong He, Zhiyi Wei, Cong Yu
Summary: This study determines the structures of KANK1 in complex with talin and liprin-b, and demonstrates how KANK1 scaffolds the FA core and associated proteins to modulate FA shape. It also reveals the liquid-liquid phase separation of KANK1, which is crucial for its localization at the FA edge and cytoskeleton connections to FAs.
Article
Biochemistry & Molecular Biology
Lenka Koudelkova, Jan Brabek, Daniel Rosel
Summary: Cells have developed a unique set of molecular mechanisms to probe the mechanical properties of their surrounding environment and transform mechanical stimuli into versatile biochemical information. Src kinase plays a central role in the mechanotransduction network, working in cooperation with primary sensors and the cytoskeleton to execute cellular responses and adaptations to mechanical cues.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Neurosciences
Benjamin T. Goult
Summary: The text proposes a hypothesis on memory storage, suggesting that memory is stored in a mechanically encoded binary format in proteins found in cell-extracellular matrix adhesions, forming a MeshCODE framework. According to the text, mechanosensitive proteins and signaling complexes represent the physical location of engrams in the brain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Veterinary Sciences
L. Etchevers, M. S. Renna, E. M. Belotti, P. U. Diaz, N. R. Salvetti, H. H. Ortega, A. N. Amweg
Summary: ACTH treatment decreases the expression of adhesion molecules in PBMCs and endothelial cells, reducing the infiltration of PBMCs and alleviating the inflammatory response during ovulation in cows.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Jae H. Sim, Nathaniel J. Himmel, Sara K. Redd, Fadi E. Pulous, Richard T. Rogers, Lauren N. Black, Seongun M. Hong, Tobias N. von Bergen, Mitsi A. Blount
Article
Multidisciplinary Sciences
R. Jason Pitts, Stephen L. Derryberry, Fadi E. Pulous, Laurence J. Zwiebel
Article
Cell Biology
Ashraf Ul Kabir, Madhav Subramanian, Dong Hun Lee, Xiaoli Wang, Karen Krchma, Jun Wu, Teri Naismith, Carmen M. Halabi, Ju Young Kim, Fadi E. Pulous, Brian G. Petrich, Suhyun Kim, Hae-Chul Park, Phyllis Hanson, Hua Pan, Samuel A. Wickline, Daved H. Fremont, Changwon Park, Kyunghee Choi
Summary: The cross-talk between angiogenesis and immunity in the tumor microenvironment is crucial for tumor prognosis. Myct1, a direct target of ETV2, plays a critical role in controlling tumor angiogenesis and reprogramming tumor immunity through regulating endothelial motility and facilitating immune cell migration. Targeting Myct1 in combination with immunotherapy may offer a promising therapeutic strategy for tumor treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Maximilian J. Schloss, Maarten Hulsmans, David Rohde, I-Hsiu Lee, Nicolas Severe, Brody H. Foy, Fadi E. Pulous, Shuang Zhang, Konstantinos D. Kokkaliaris, Vanessa Frodermann, Gabriel Courties, Chongbo Yang, Yoshiko Iwamoto, Anders Steen Knudsen, Cameron S. McAlpine, Masahiro Yamazoe, Stephen P. Schmidt, Gregory R. Wojtkiewicz, Gustavo Santos Masson, Karin Gustafsson, Diane Capen, Dennis Brown, John M. Higgins, David T. Scadden, Peter Libby, Filip K. Swirski, Kamila Naxerova, Matthias Nahrendorf
Summary: The study reveals that B cells in the bone marrow are a significant source of the neurotransmitter acetylcholine, which regulates hematopoiesis by modulating the signals from the bone marrow stromal niche. This finding sheds light on the role of neural regulation in hematopoiesis and has important implications for understanding the mechanisms underlying hematopoiesis.
Article
Neurosciences
Fadi E. Pulous, Jean C. Cruz-Hernandez, Chongbo Yang, Zeynep Kaya, Alexandre Paccalet, Gregory Wojtkiewicz, Diane Capen, Dennis Brown, Juwell W. Wu, Maximilian J. Schloss, Claudio Vinegoni, Dmitry Richter, Masahiro Yamazoe, Maarten Hulsmans, Noor Momin, Jana Grune, David Rohde, Cameron S. McAlpine, Peter Panizzi, Ralph Weissleder, Dong-Eog Kim, Filip K. Swirski, Charles P. Lin, Michael A. Moskowitz, Matthias Nahrendorf
Summary: Interactions between the immune and central nervous systems are crucial for brain health. Meningeal gateways through brain border tissues facilitate communication between these systems. The cerebrospinal fluid can exit into the skull bone marrow, allowing outward signaling beyond the blood-brain barrier.
NATURE NEUROSCIENCE
(2022)
Correction
Immunology
Maximilian J. Schloss, Maarten Hulsmans, David Rohde, I-Hsiu Lee, Nicolas Severe, Brody H. Foy, Fadi E. Pulous, Shuang Zhang, Konstantinos D. Kokkaliaris, Vanessa Frodermann, Gabriel Courties, Chongbo Yang, Yoshiko Iwamoto, Anders Steen Knudsen, Cameron S. McAlpine, Masahiro Yamazoe, Stephen P. Schmidt, Gregory R. Wojtkiewicz, Gustavo Santos Masson, Karin Gustafsson, Diane Capen, Dennis Brown, John M. Higgins, David T. Scadden, Peter Libby, Filip K. Swirski, Kamila Naxerova, Matthias Nahrendorf
Review
Medicine, Research & Experimental
Fadi E. Pulous, Brian G. Petrich
Article
Physiology
Carol A. Hoban, Lauren N. Black, Ronald J. Ordas, Diane L. Gumina, Fadi E. Pulous, Jae H. Sim, Jeff M. Sands, Mitsi A. Blount
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2015)