Angiopoietin-2 Inhibition Rescues Arteriovenous Malformation in a Smad4 Hereditary Hemorrhagic Telangiectasia Mouse Model

Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia

(2018) Angela M. Crist et al.   ANGIOGENESIS

SMAD4 Prevents Flow Induced Arterial-Venous Malformations by Inhibiting Casein Kinase 2

(2018) Roxana Ola et al.   CIRCULATION

Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined with Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors

(2018) David M. Hyman et al.   CLINICAL CANCER RESEARCH

SMAD4 gene mutation increases the risk of aortic dilation in patients with hereditary haemorrhagic telangiectasia

(2017) V.M.M. Vorselaars et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

(2017) Takako Saito et al.   Cell Reports

Alk1 controls arterial endothelial cell migration in lumenized vessels

(2016) Elizabeth R. Rochon et al.   DEVELOPMENT

Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases

(2016) Jörg T Regula et al.   EMBO Molecular Medicine

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

(2016) Roxana Ola et al.   Nature Communications

A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors

(2015) K. P. Papadopoulos et al.   CLINICAL CANCER RESEARCH

BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia

(2013) Whitney L. Wooderchak-Donahue et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence

(2013) D. W. Laux et al.   DEVELOPMENT

Enhanced Responses to Angiogenic Cues Underlie the Pathogenesis of Hereditary Hemorrhagic Telangiectasia 2

(2013) Eun-Jung Choi et al.   PLoS One

Age-Dependent Lethality in Novel Transgenic Mouse Models of Central Nervous System Arteriovenous Malformations

(2012) Ian Milton et al.   STROKE

Interaction between alk1 and blood flow in the development of arteriovenous malformations

(2011) P. Corti et al.   DEVELOPMENT

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers

(2011) Nithya Baburajendran et al.   NUCLEIC ACIDS RESEARCH

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY