Review
Biochemistry & Molecular Biology
Kashi Raj Bhattarai, Thoufiqul Alam Riaz, Hyung-Ryong Kim, Han-Jung Chae
Summary: The endoplasmic reticulum (ER) plays crucial roles in protein synthesis and folding in eukaryotic cells. The unfolded protein response (UPR) is triggered by disturbances in ER function, aiming to restore cellular homeostasis but possibly leading to apoptotic signaling under prolonged stress. The complex interactions between ER stress, redox imbalance, and oxidative stress can have profound negative impacts on cellular physiology and targeting these stress mechanisms may be a promising approach for disease treatment.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Stephanie M. Cicalese, Josiane Fernandes da Silva, Fernanda Priviero, R. Clinton Webb, Satoru Eguchi, Rita C. Tostes
Summary: Cells respond to stress by activating defense signaling pathways for survival or cell death. Arterial hypertension and aging share mechanisms that mediate chronic cell stress, potentially leading to unresolved pathologies.
CIRCULATION RESEARCH
(2021)
Review
Cell Biology
Pengcheng Zhang, Daniels Konja, Yiwei Zhang, Yu Wang
Summary: MAM serves as a crucial hub for integrating cellular and organelle homeostasis, facilitating adaptation of energy metabolism. Abnormalities in MAM can lead to impaired insulin sensitivity and metabolic diseases.
Review
Biochemistry & Molecular Biology
Vaishali Kumar, Shuvadeep Maity
Summary: Recent studies have highlighted the significance of inter organelle connections in maintaining cellular homeostasis, particularly the specialized physical connection between the endoplasmic reticulum (ER) and mitochondria at the mitochondria-associated ER membrane (MAM). While IRE1alpha and PERK are well-known for their canonical role as ER stress sensors, their potential non-canonical functions at the MAM beyond ER stress signaling have become a focus of current research.
Review
Oncology
Linlin Zhang, Furong Yan, Liyang Li, Huirong Fu, Dongli Song, Duojiao Wu, Xiangdong Wang
Summary: The communication between endoplasmic reticulum (ER) and mitochondria (Mt) is crucial for maintaining cellular microenvironments, metabolisms, signaling activities, and cell-cell communication. Understanding the molecular mechanisms of ER-Mt communication is essential for identifying and developing specific biomarkers and therapeutic targets for human diseases. The inhibitors and modulators of ER-Mt communication are categorized according to therapeutic targets, and advancements in biotechnologies will provide new insights into the molecular mechanisms of ER-Mt communication.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Yuan Che, Wanfen Xu, Chujie Ding, Tianyu He, Xiaowei Xu, Yubing Shuai, Hai Huang, Jiawei Wu, Yun Wang, Chen Wang, Guangji Wang, Lijuan Cao, Haiping Hao
Summary: Bile acids serve as endogenous ligands of mitofusin 2 (MFN2) and regulate innate immune response to bacterial infection under cholestatic and physiological conditions. At high concentrations, bile acids promote the activation of NLRP3 inflammasome and pyroptosis, while at physiologically relevant low concentrations, they enhance mitochondrial fusion and strengthen macrophage-mediated phagocytotic clearance. These findings highlight the important role of bile acids as activators of MFN2 in shaping innate immune responses against infections, connecting systemic metabolism with mitochondrial dynamics.
Article
Multidisciplinary Sciences
Jinghong Xu, Takuya Hashino, Reiji Tanaka, Koichiro Kawaguchi, Hideki Yoshida, Takao Kataoka
Summary: BCL-RAMBO interacts with GRP75 and mortalin, and mediates apoptosis by activating caspases and cleaving PARP-1.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Olena Odnokoz, Noah Earland, Marziyeh Badinloo, Vladimir I. Klichko, Judith Benes, William C. Orr, Svetlana N. Radyuk
Summary: Aberrant immune responses and chronic inflammation can increase health risks and promote premature aging. Peroxiredoxins (Prxs) play a critical role in maintaining cellular redox homeostasis and regulating the immune response. The activity of mitochondrial Prxs in the intestinal epithelium is important for preventing intestinal barrier dysfunction, systemic inflammation, and premature aging.
Article
Biochemistry & Molecular Biology
Chaonan Jin, Eric Felli, Naomi Franziska Lange, Annalisa Berzigotti, Jordi Gracia-Sancho, Jean-Francois Dufour
Summary: The interaction between the mitochondria and the endoplasmic reticulum (ER) plays a crucial role in hepatocyte function. The abundance of ER-mitochondria contacts (ERMCs) is associated with the severity of non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH). The density of ERMCs increases with the number of metabolic syndrome (MetS) features, suggesting a role for this interaction in the pathophysiology of NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cecilia Marini, Vanessa Cossu, Matteo Bauckneht, Sonia Carta, Francesco Lanfranchi, Francesca D'Amico, Silvia Ravera, Anna Maria Orengo, Chiara Ghiggi, Filippo Ballerini, Paolo Durando, Sabrina Chiesa, Alberto Miceli, Maria Isabella Donegani, Silvia Morbelli, Silvia Bruno, Gianmario Sambuceti
Summary: This study found that PBMCs in patients with Hodgkin's lymphoma exhibit selective mitochondrial and ER redox stress, particularly in lymphocytes, even before chemotherapy exposure.
Review
Biochemistry & Molecular Biology
Na Song, Ming Yang, Hao Zhang, Shi-kun Yang
Summary: Kidney disease is a serious health concern, and understanding the pathogenesis is crucial for precise therapies. Disruption of calcium homeostasis plays a fundamental role in kidney disease development and is a promising therapeutic strategy. The endoplasmic reticulum and mitochondria are key organelles, with pharmacologic modulation of cellular calcium homeostasis as a novel treatment approach.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Chaonan Jin, Pavitra Kumar, Jordi Gracia-Sancho, Jean-Francois Dufour
Summary: Calcium is a crucial second messenger in cellular homeostasis, with its exchange facilitated by mitochondrial-associated membranes. Disrupted Ca2+ signaling and proteins regulating ER-mitochondria interactions are associated with various liver diseases.
Review
Cell Biology
Andrea Markovinovic, Jenny Greig, Sandra Maria Martin-Guerrero, Shaakir Salam, Sebastien Paillusson
Summary: Recent advances have uncovered common pathological changes in neurodegenerative diseases, with a particular focus on the role of endoplasmic reticulum (ER)-mitochondria signaling and mitochondria-associated membranes (MAMs). MAMs appear to be associated with major neurodegenerative diseases and have been found to regulate neuronal health and synaptic transmission. Damage to the ER-mitochondria axis disrupts vital processes, leading to neurodegeneration.
JOURNAL OF CELL SCIENCE
(2022)
Review
Cell Biology
Nan Wang, Chong Wang, Hongyang Zhao, Yichun He, Beiwu Lan, Liankun Sun, Yufei Gao
Summary: The cooperation and antagonism between organelles within the cell play a crucial role in maintaining cellular homeostasis. The signaling crosstalk between the endoplasmic reticulum (ER) and mitochondria influences cell fate. Mitochondria-associated membranes (MAMs) are pivotal in regulating lipid synthesis, calcium homeostasis, ER-mitochondrial coordination, and death signal transduction, contributing to cell death mechanisms such as apoptosis.
Review
Endocrinology & Metabolism
Jin-Ho Koh, Yong-Woon Kim, Dae-Yun Seo, Tae-Seo Sohn
Summary: Tissues actively involved in energy metabolism are more susceptible to metabolic diseases due to mitochondrial dysfunction linked to Ca2+ flux regulation. Mitochondria play a crucial role in transmitting signals about cellular metabolic states, affecting the incidence of metabolic diseases like insulin resistance and type 2 diabetes mellitus. Mitochondrial transcription factor A (Tfam) may regulate Ca2+ flux to coordinate mitochondria-ER activities and mitigate the impact of metabolic challenges on mitochondrial function.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Jie Wang, Carolyn S. Sevier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Mengni Xu, Heather M. Marsh, Carolyn S. Sevier
JOURNAL OF MOLECULAR BIOLOGY
(2016)
Article
Biology
Kevin D. Siegenthaler, Kristeen A. Pareja, Jie Wang, Carolyn S. Sevier
Article
Biochemistry & Molecular Biology
John P. O'Donnell, Heather M. Marsh, Holger Sondermann, Carolyn S. Sevier
Review
Biochemistry & Molecular Biology
Lars Ellgaard, Carolyn S. Sevier, Neil J. Bulleid
TRENDS IN BIOCHEMICAL SCIENCES
(2018)
Review
Biochemistry & Molecular Biology
Carolyn S. Sevier
ANTIOXIDANTS & REDOX SIGNALING
(2012)
Article
Biochemistry & Molecular Biology
Elvira Vitu, Sunghwan Kim, Carolyn S. Sevier, Omer Lutzky, Nimrod Heldman, Moran Bentzur, Tamar Unger, Meital Yona, Chris A. Kaiser, Deborah Fass
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Editorial Material
Cell Biology
Carolyn S. Sevier
JOURNAL OF CELL BIOLOGY
(2010)
Article
Cell Biology
Sunghwan Kim, Dionisia P. Sideris, Carolyn S. Sevier, Chris A. Kaiser
JOURNAL OF CELL BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Nimrod Heldman, Ohad Vonshak, Carolyn S. Sevier, Elvira Vitu, Tevie Mehlman, Deborah Fass
Article
Veterinary Sciences
J. P. Loftus, D. Cavatorta, J. J. Bushey, C. B. Levine, C. S. Sevier, J. J. Wakshlag
VETERINARY AND COMPARATIVE ONCOLOGY
(2016)
Article
Biology
Jie Wang, Kristeen A. Pareja, Chris A. Kaiser, Carolyn S. Sevier
Article
Biochemistry & Molecular Biology
Erin E. Nicklow, Carolyn S. Sevier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Review
Cell Biology
Jennifer M. Roscoe, Carolyn S. Sevier
